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- W2895921164 abstract "Aggregation and deposition of amyloid-β (Aβ) in the brain is the main pathological change observed in Alzheimer's disease (AD). Decreased Aβ42 in the cerebrospinal fluid (CSF) has been confirmed as a biomarker of AD, however, the relationship between plasma Aβ and cognitive impairment (CI) is currently unclear. The aim was to explore the relationship between plasma Aβ and cognitive impairment in a cross-sectional study. A total of 1314 subjects (age above 40) from a village in the suburbs of Xi'an, China were enrolled between Oct 8, 2014 and Mar 30, 2015. A validated Chinese version of the Mini-Mental State Examination (MMSE) and neuropsychological battery were used to assess cognition. Levels of plasma Aβ42 and Aβ40 were tested using commercial enzyme-linked immunosorbent assay (ELISA). Relationship of plasma Aβ and cognitive impairment was analyzed using logistic regression analysis. Of the enrolled subjects, 1180 (89.80%) had normal cognition, 85 (6.47%) had possible cognitive impairment and 49 (3.73%) had probable cognitive impairment. Logistic regression analysis showed that the Aβ42/Aβ40 ratio (OR=4.042, 95% CI: 1.248-11.098, P=0.012) and plasma Aβ42 (OR=1.036, 95% CI:1.003-1.071, P=0.031) was higher in the possible cognitive impairment than that in normal cognition group. Furthermore, the plasma Aβ42/Aβ40 ratio was higher in the possible cognitive impairment group than the probable cognitive impairment group (OR = 0.029,95% CI:0.002-0.450, P = 0.011). Levels of plasma Aβ42 and Aβ42/Aβ40 ratio were elevated in patients with possible cognitive impairment, indicating that plasma Aβ42 and Aβ42/Aβ40 ratio increases may be more pronounced in early stage of cognitive impairment." @default.
- W2895921164 created "2018-10-26" @default.
- W2895921164 creator A5018244700 @default.
- W2895921164 date "2018-07-01" @default.
- W2895921164 modified "2023-10-16" @default.
- W2895921164 title "P3‐223: ELEVATION OF PLASMA AMYLOID‐β LEVEL IS MORE SIGNIFICANT IN EARLY STAGE OF COGNITIVE IMPAIRMENT: A POPULATION‐BASED CROSS‐SECTIONAL STUDY" @default.
- W2895921164 doi "https://doi.org/10.1016/j.jalz.2018.06.1582" @default.
- W2895921164 hasPublicationYear "2018" @default.
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