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- W2895922710 abstract "Benzene is a ubiquitous pollutant associated with hematotoxicity but its metabolic effects are unknown. We sought to determine if and how exposure to volatile benzene impacted glucose handling. We exposed wild type C57BL/6 mice to volatile benzene (50 ppm × 6 h/day) or HEPA-filtered air for 2 or 6 weeks and measured indices of oxidative stress, inflammation, and insulin signaling. Compared with air controls, we found that mice inhaling benzene demonstrated increased plasma glucose (p = .05), insulin (p = .03), and HOMA-IR (p = .05), establishing a state of insulin and glucose intolerance. Moreover, insulin-stimulated Akt phosphorylation was diminished in the liver (p = .001) and skeletal muscle (p = .001) of benzene-exposed mice, accompanied by increases in oxidative stress and Nf-κb phosphorylation (p = .025). Benzene-exposed mice also demonstrated elevated levels of Mip1-α transcripts and Socs1 (p = .001), but lower levels of Irs-2 tyrosine phosphorylation (p = .0001). Treatment with the superoxide dismutase mimetic, TEMPOL, reversed benzene-induced effects on oxidative stress, Nf-κb phosphorylation, Socs1 expression, Irs-2 tyrosine phosphorylation, and systemic glucose intolerance. These findings suggest that exposure to benzene induces insulin resistance and that this may be a sensitive indicator of inhaled benzene toxicity. Persistent ambient benzene exposure may be a heretofore unrecognized contributor to the global human epidemics of diabetes and cardiovascular disease." @default.
- W2895922710 created "2018-10-26" @default.
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- W2895922710 date "2018-10-22" @default.
- W2895922710 modified "2023-10-17" @default.
- W2895922710 title "Benzene Exposure Induces Insulin Resistance in Mice" @default.
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- W2895922710 doi "https://doi.org/10.1093/toxsci/kfy252" @default.
- W2895922710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6358255" @default.
- W2895922710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30346588" @default.
- W2895922710 hasPublicationYear "2018" @default.
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