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• W2895924907 abstract "B cell activation and differentiation are associated with marked changes in proliferative and effector functions. Each stage of B cell differentiation thus has unique metabolic demands. New studies have provided insight on how nutrient uptake and usage by B cells are regulated by B cell receptor signals, autophagy, mammalian target of rapamycin, and transcriptional control of transporters and rate-limiting enzymes. A recurring theme is that these pathways play distinct roles ranging from survival to antibody production, depending on the B cell fate. We review recently published data that define how these pathways control metabolic flux in B cells, with a particular emphasis on genetic and in vivo evidence. We further discuss how lessons from T cells can guide future directions." @default.
• W2895924907 created "2018-10-26" @default.
• W2895924907 creator A5011630697 @default.
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• W2895924907 date "2019-04-01" @default.
• W2895924907 modified "2023-10-06" @default.
• W2895924907 title "Regulation of metabolic supply and demand during B cell activation and subsequent differentiation" @default.
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• W2895924907 doi "https://doi.org/10.1016/j.coi.2018.10.003" @default.
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