Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895925712> ?p ?o ?g. }
- W2895925712 abstract "Abstract Targeting the expansion of pathogenic memory immune cells is a promising therapeutic strategy to prevent chronic autoimmune attacks. Here we investigate the therapeutic efficacy and mechanism of new anti-human IL-7Rα monoclonal antibodies (mAb) in non-human primates and show that, depending on the target epitope, a single injection of antagonistic anti-IL-7Rα mAbs induces a long-term control of skin inflammation despite repeated antigen challenges in presensitized monkeys. No modification in T cell numbers, phenotype, function or metabolism is observed in the peripheral blood or in response to polyclonal stimulation ex vivo. However, long-term in vivo hyporesponsiveness is associated with a significant decrease in the frequency of antigen-specific T cells producing IFN-γ upon antigen restimulation ex vivo. These findings indicate that chronic antigen-specific memory T cell responses can be controlled by anti-IL-7Rα mAbs, promoting and maintaining remission in T-cell mediated chronic inflammatory diseases." @default.
- W2895925712 created "2018-10-26" @default.
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- W2895925712 date "2018-10-26" @default.
- W2895925712 modified "2023-10-17" @default.
- W2895925712 title "IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates" @default.
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- W2895925712 doi "https://doi.org/10.1038/s41467-018-06804-y" @default.
- W2895925712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6203796" @default.
- W2895925712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30367166" @default.
- W2895925712 hasPublicationYear "2018" @default.
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