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• W2895932830 endingPage "016008" @default.
• W2895932830 startingPage "016008" @default.
• W2895932830 abstract "The ability to orient with respect to the current context (e.g. current time or location) is crucial for daily functioning, and is used to measure overall cognitive health across many frontline clinical assessments. However, these tests are often hampered by their reliance on verbal probes (e.g. 'What city are we in?') in evaluating orientation. Objective, physiology-based measures of orientation processing are needed, but no such measures are currently in existence. We report the initial development of potential brainwave-based markers of orientation processing as characterized using electroencephlography (EEG) and magnetoencephalography (MEG).An auditory stimulus sequence embedded with words corresponding to orientation-relevant (i.e. related to the 'here and now') and orientation-irrelevant (i.e. unrelated to the current context) conditions was used to elicit orientation processing responses. EEG/MEG data, in concert with clinical assessments, were collected from 29 healthy adults. Analysis at sensor and source levels identified and characterized neural signals related to orientation processing.Orientation-irrelevant stimuli elicited increased negative amplitude in EEG-derived event-related potential (ERP) waveforms during the 390-570 ms window (p < 0.05), with cortical activations across the left frontal, temporal, and parietal regions. These effects are consistent with the well-known N400 response to semantic incongruence. In contrast, ERP responses to orientation-relevant stimuli exhibited increased positive amplitude during the same interval (p < 0.05), with activations across the bilateral temporal and parietal regions. Importantly, these differential responses were robust at the individual level, with machine-learning classification showing high accuracy (89%), sensitivity (0.88) and specificity (0.90).This is the first demonstration of a neurotechnology platform that elicits, captures, and evaluates electrophysiological markers of orientation processing. We demonstrate neural responses to orientation stimuli that are validated across EEG and MEG modalities and robust at the individual level. The extraction of physiology-based markers through this technique may enable improved objective brain functional evaluation in clinical applications." @default.
• W2895932830 created "2018-10-26" @default.
• W2895932830 creator A5001853550 @default.
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• W2895932830 date "2018-12-03" @default.
• W2895932830 modified "2023-09-27" @default.
• W2895932830 title "Accessing knowledge of the ‘here and now’: a new technique for capturing electromagnetic markers of orientation processing" @default.
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• W2895932830 doi "https://doi.org/10.1088/1741-2552/aae91e" @default.
• W2895932830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30507557" @default.
• W2895932830 hasPublicationYear "2018" @default.
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