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- W2895933735 endingPage "286" @default.
- W2895933735 startingPage "241" @default.
- W2895933735 abstract "Central nervous system (CNS) disorders are one of the most life style-affecting diseases. There was immense financial burden on the management of various disorders that are localized in brain. Majority of the available systemic treatments for the local brain disorders failed due to the inability of the drugs to cross blood-brain barrier. Many approaches have been used to improve brain bioavailability of various promising candidates. But the systemic therapy always invites nonspecific activity to other tissues, even though the drug permeates at significant concentrations. Similarly, these approaches cannot maintain significant concentrations of drug at specific sites like tumor, infected parenchymal lining, etc. These issues paved way for the development of local drug delivery systems for brain. These systems were effective in maintaining significant concentrations of drug at target site, thus reducing dose and toxicity. This chapter will discuss about the local drug delivery strategies to brain. The chapter starts with the introduction to CNS. This will be followed by brief introduction for local drug delivery followed by potential applications. All the local drug delivery strategies to brain are discussed in detail. This is then followed by marketed products for these approaches and clinical trials involving local drug delivery strategies were also reported in the chapter." @default.
- W2895933735 created "2018-10-26" @default.
- W2895933735 creator A5032619701 @default.
- W2895933735 creator A5067597612 @default.
- W2895933735 creator A5089618922 @default.
- W2895933735 date "2019-01-01" @default.
- W2895933735 modified "2023-09-27" @default.
- W2895933735 title "Brain local delivery strategy" @default.
- W2895933735 cites W1498017834 @default.
- W2895933735 cites W1508419963 @default.
- W2895933735 cites W1543931630 @default.
- W2895933735 cites W1567767966 @default.
- W2895933735 cites W1655997880 @default.
- W2895933735 cites W176021971 @default.
- W2895933735 cites W1773423842 @default.
- W2895933735 cites W1926220930 @default.
- W2895933735 cites W1939685405 @default.
- W2895933735 cites W1963946540 @default.
- W2895933735 cites W1965894523 @default.
- W2895933735 cites W1966174640 @default.
- W2895933735 cites W1969518594 @default.
- W2895933735 cites W1969757140 @default.
- W2895933735 cites W1969757222 @default.
- W2895933735 cites W1969914493 @default.
- W2895933735 cites W1977253304 @default.
- W2895933735 cites W1977464265 @default.
- W2895933735 cites W1977491019 @default.
- W2895933735 cites W1979368164 @default.
- W2895933735 cites W1981233223 @default.
- W2895933735 cites W1981624978 @default.
- W2895933735 cites W1984136242 @default.
- W2895933735 cites W1984328540 @default.
- W2895933735 cites W1984752093 @default.
- W2895933735 cites W1985057055 @default.
- W2895933735 cites W1987615424 @default.
- W2895933735 cites W1988003567 @default.
- W2895933735 cites W1990623322 @default.
- W2895933735 cites W1993640941 @default.
- W2895933735 cites W1993725418 @default.
- W2895933735 cites W1996162729 @default.
- W2895933735 cites W1997894803 @default.
- W2895933735 cites W1998020561 @default.
- W2895933735 cites W1998731236 @default.
- W2895933735 cites W2001018507 @default.
- W2895933735 cites W2002028021 @default.
- W2895933735 cites W2002386579 @default.
- W2895933735 cites W2002547990 @default.
- W2895933735 cites W2005371778 @default.
- W2895933735 cites W2005431774 @default.
- W2895933735 cites W2006104156 @default.
- W2895933735 cites W2007719782 @default.
- W2895933735 cites W2009079705 @default.
- W2895933735 cites W2009244092 @default.
- W2895933735 cites W2015504271 @default.
- W2895933735 cites W2015946765 @default.
- W2895933735 cites W2017925961 @default.
- W2895933735 cites W2018213285 @default.
- W2895933735 cites W2018522439 @default.
- W2895933735 cites W2019850340 @default.
- W2895933735 cites W2020177708 @default.
- W2895933735 cites W2020398834 @default.
- W2895933735 cites W2021493191 @default.
- W2895933735 cites W2022905526 @default.
- W2895933735 cites W2028892040 @default.
- W2895933735 cites W2028929157 @default.
- W2895933735 cites W2030557341 @default.
- W2895933735 cites W2031984356 @default.
- W2895933735 cites W2031999748 @default.
- W2895933735 cites W2032090704 @default.
- W2895933735 cites W2033524239 @default.
- W2895933735 cites W2034334345 @default.
- W2895933735 cites W2035338985 @default.
- W2895933735 cites W2036560693 @default.
- W2895933735 cites W2037794981 @default.
- W2895933735 cites W2040022930 @default.
- W2895933735 cites W2041366750 @default.
- W2895933735 cites W2042295385 @default.
- W2895933735 cites W2042865265 @default.
- W2895933735 cites W2043255383 @default.
- W2895933735 cites W2045451897 @default.
- W2895933735 cites W2045650216 @default.
- W2895933735 cites W2049149624 @default.
- W2895933735 cites W2049958682 @default.
- W2895933735 cites W2052580681 @default.
- W2895933735 cites W2052892795 @default.
- W2895933735 cites W205461530 @default.
- W2895933735 cites W2054889018 @default.
- W2895933735 cites W2055264482 @default.
- W2895933735 cites W2055881439 @default.
- W2895933735 cites W2061799155 @default.
- W2895933735 cites W2063689414 @default.
- W2895933735 cites W2064079544 @default.
- W2895933735 cites W2064658833 @default.
- W2895933735 cites W2065634295 @default.
- W2895933735 cites W2070781226 @default.
- W2895933735 cites W2071961683 @default.
- W2895933735 cites W2072757173 @default.
- W2895933735 cites W2074049796 @default.