FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895934797> ?p ?o ?g. }

• W2895934797 endingPage "187" @default.
• W2895934797 startingPage "187" @default.
• W2895934797 abstract "Tadalafil is an oral selective phosphodiesterase type-5 inhibitor with demonstrated efficacy and safety that is used to treat erectile dysfunction. The purpose of this study is to compare the pharmacokinetic properties of tadalafil after conventional oral tablet administration and novel intranasal administration in beagle dogs. Fourteen 13-month-old male beagle dogs were randomly divided into two groups, and were given 5 mg tadalafil orally or intranasally in a parallel design. Blood samples were collected before and 0.5, 1, 1.5, 2, 4, 6, 8, 12, 24, and 36 h after administration. The plasma concentration of tadalafil was determined via liquid chromatography-tandem mass spectrometry (LC-MS/MS). The systemic exposure and absorption rate of tadalafil were significantly greater in the intranasal administration group than in the oral administration group. A one-compartment model with first-order absorption and elimination was sufficient to explain the pharmacokinetic characteristics observed after both oral and intranasal administration. This study indicates that the development of tadalafil nasal delivery systems is feasible and may lead to better results than the conventional oral route." @default.
• W2895934797 created "2018-10-26" @default.
• W2895934797 creator A5027341772 @default.
• W2895934797 creator A5028070594 @default.
• W2895934797 creator A5029272480 @default.
• W2895934797 date "2018-10-15" @default.
• W2895934797 modified "2023-10-18" @default.
• W2895934797 title "Enhanced Bioavailability of Tadalafil after Intranasal Administration in Beagle Dogs" @default.
• W2895934797 cites W1556466550 @default.
• W2895934797 cites W1584504335 @default.
• W2895934797 cites W1964561331 @default.
• W2895934797 cites W1975119053 @default.
• W2895934797 cites W1991260622 @default.
• W2895934797 cites W2004405846 @default.
• W2895934797 cites W2006420230 @default.
• W2895934797 cites W2014711248 @default.
• W2895934797 cites W2016646028 @default.
• W2895934797 cites W2018340655 @default.
• W2895934797 cites W2018540180 @default.
• W2895934797 cites W2022487519 @default.
• W2895934797 cites W2074912251 @default.
• W2895934797 cites W2075226660 @default.
• W2895934797 cites W2084899588 @default.
• W2895934797 cites W2085095071 @default.
• W2895934797 cites W2085264307 @default.
• W2895934797 cites W2086776758 @default.
• W2895934797 cites W2088525052 @default.
• W2895934797 cites W2097813267 @default.
• W2895934797 cites W2121939064 @default.
• W2895934797 cites W2267659141 @default.
• W2895934797 cites W2592334712 @default.
• W2895934797 cites W2607212163 @default.
• W2895934797 cites W2802185643 @default.
• W2895934797 doi "https://doi.org/10.3390/pharmaceutics10040187" @default.
• W2895934797 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6321473" @default.
• W2895934797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30326564" @default.
• W2895934797 hasPublicationYear "2018" @default.
• W2895934797 type Work @default.
• W2895934797 sameAs 2895934797 @default.
• W2895934797 citedByCount "10" @default.
• W2895934797 countsByYear W28959347972019 @default.
• W2895934797 countsByYear W28959347972020 @default.
• W2895934797 countsByYear W28959347972022 @default.
• W2895934797 countsByYear W28959347972023 @default.
• W2895934797 crossrefType "journal-article" @default.
• W2895934797 hasAuthorship W2895934797A5027341772 @default.
• W2895934797 hasAuthorship W2895934797A5028070594 @default.
• W2895934797 hasAuthorship W2895934797A5029272480 @default.
• W2895934797 hasBestOaLocation W28959347971 @default.
• W2895934797 hasConcept C112705442 @default.
• W2895934797 hasConcept C121332964 @default.
• W2895934797 hasConcept C125287762 @default.
• W2895934797 hasConcept C126322002 @default.
• W2895934797 hasConcept C181389837 @default.
• W2895934797 hasConcept C24890656 @default.
• W2895934797 hasConcept C2776093070 @default.
• W2895934797 hasConcept C2776820430 @default.
• W2895934797 hasConcept C2777056448 @default.
• W2895934797 hasConcept C2779929075 @default.
• W2895934797 hasConcept C2780816001 @default.
• W2895934797 hasConcept C71924100 @default.
• W2895934797 hasConcept C74534348 @default.
• W2895934797 hasConcept C85663871 @default.
• W2895934797 hasConcept C98274493 @default.
• W2895934797 hasConceptScore W2895934797C112705442 @default.
• W2895934797 hasConceptScore W2895934797C121332964 @default.
• W2895934797 hasConceptScore W2895934797C125287762 @default.
• W2895934797 hasConceptScore W2895934797C126322002 @default.
• W2895934797 hasConceptScore W2895934797C181389837 @default.
• W2895934797 hasConceptScore W2895934797C24890656 @default.
• W2895934797 hasConceptScore W2895934797C2776093070 @default.
• W2895934797 hasConceptScore W2895934797C2776820430 @default.
• W2895934797 hasConceptScore W2895934797C2777056448 @default.
• W2895934797 hasConceptScore W2895934797C2779929075 @default.
• W2895934797 hasConceptScore W2895934797C2780816001 @default.
• W2895934797 hasConceptScore W2895934797C71924100 @default.
• W2895934797 hasConceptScore W2895934797C74534348 @default.
• W2895934797 hasConceptScore W2895934797C85663871 @default.
• W2895934797 hasConceptScore W2895934797C98274493 @default.
• W2895934797 hasFunder F4320322120 @default.
• W2895934797 hasIssue "4" @default.
• W2895934797 hasLocation W28959347971 @default.
• W2895934797 hasLocation W28959347972 @default.
• W2895934797 hasLocation W28959347973 @default.
• W2895934797 hasLocation W28959347974 @default.
• W2895934797 hasLocation W28959347975 @default.
• W2895934797 hasLocation W28959347976 @default.
• W2895934797 hasOpenAccess W2895934797 @default.
• W2895934797 hasPrimaryLocation W28959347971 @default.
• W2895934797 hasRelatedWork W1555144605 @default.
• W2895934797 hasRelatedWork W1937556892 @default.
• W2895934797 hasRelatedWork W2001333918 @default.
• W2895934797 hasRelatedWork W2061323067 @default.
• W2895934797 hasRelatedWork W2069936009 @default.
• W2895934797 hasRelatedWork W2160414036 @default.
• W2895934797 hasRelatedWork W2316174115 @default.
• W2895934797 hasRelatedWork W2317627837 @default.
• W2895934797 hasRelatedWork W2377709157 @default.

• next