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• W2895945014 abstract "Currently, accumulated a large amount of data on the role of inflammation in the vascular endothelium damage during the development of the chronic forms of many diseases. THE AIM: identification of endothelial dysfunction (ED) biomarkers as early predictors of CKD development in patients with chronic lung diseases. PATIENTS AND METHODS. 123 patients with COPD aged 55-79 years were examined, studied features of clinical and anthropometric parameters, data of the main biochemical systemic inflammation markers and vascular endothelial dysfunction, their significance in the development of chronic kidney disease (CKD). RESULTS. For the first time CKD was diagnosed in 51.2% of patients with COPD. In comorbid patients with COPD and related CKD noted more severe course of disease. Also in these patients detected significantly elevated endothelial dysfunction indices. CRP and fibrinogen levels were higher in all patients with COPD and authentically correlated with disease severety. Direct correlation between CRP and TNF-α levels was revealed. Noted that tumor necrosis factor was higher in smoker patients with COPD. Markers of kidneys endothelial dysfunction – homocysteine, IL-6, IL-8 – were significantly higher in patients with decreased GFR. Also in these patients were detected increased levels of serum creatinine and urea. Creatinine clearance inversely correlated with homocysteine plasma level. In all cases of fibrinogen increase in patients with COPD. Homocysteine level was also increased, but in combination with CKD it was significantly higher: respectively 19,8±7,51 and 39,8 ± 7,14 μmol/L, p<0,005. CONCLUSION. The received information confirms the hypothesis about the relationship of ED biomarkers homocysteine, TNF-α, IL-6, IL-8 with the development of chronic kidney disease in comorbid patients with COPD." @default.
• W2895945014 created "2018-10-26" @default.
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• W2895945014 date "2018-10-08" @default.
• W2895945014 modified "2023-09-27" @default.
• W2895945014 title "PROGNOSTIC SIGNIFICANCE OF SOME MARKERS OF ENDOTHELIAL DYSFUNCTION IN THE DEVELOPMENT OF CHRONIC KIDNEY PATHOLOGY IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE" @default.
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• W2895945014 doi "https://doi.org/10.24884/1561-6274-2018-22-5-25-30" @default.
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