Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895946809> ?p ?o ?g. }
- W2895946809 endingPage "3842" @default.
- W2895946809 startingPage "3818" @default.
- W2895946809 abstract "The vascular mechanical microenvironment consists of a mixture of spatially and temporally changing mechanical forces. This exposes vascular endothelial cells to both hemodynamic forces (fluid flow, cyclic stretching, lateral pressure) and vessel forces (basement membrane mechanical and topographical properties). The vascular mechanical microenvironment is because these forces are dynamic and interrelated. Endothelial cells sense these forces through mechanosensory structures and transduce them into functional responses via mechanotransduction pathways, culminating in behavior directly affecting vascular health. Recent in vitro studies have shown that endothelial cells respond in nuanced and unique ways to combinations of hemodynamic and vessel forces as compared to any single mechanical force. Understanding the interactive effects of the complex mechanical microenvironment on vascular endothelial behavior offers the opportunity to design future biomaterials and biomedical devices from the bottom-up by engineering for the cellular response. This review describes and defines (1) the blood vessel structure, (2) the complex mechanical microenvironment of the vascular endothelium, (3) the process in which vascular endothelial cells sense mechanical forces, and (4) the effect of mechanical forces on vascular endothelial cells with specific attention to recent works investigating the influence of combinations of mechanical forces. We conclude this review by providing our perspective on how the field can move forward to elucidate the effects of the complex mechanical microenvironment on vascular endothelial cell behavior." @default.
- W2895946809 created "2018-10-26" @default.
- W2895946809 creator A5036162806 @default.
- W2895946809 creator A5063000820 @default.
- W2895946809 date "2018-10-22" @default.
- W2895946809 modified "2023-10-01" @default.
- W2895946809 title "Vascular Endothelial Cell Behavior in Complex Mechanical Microenvironments" @default.
- W2895946809 cites W1482522524 @default.
- W2895946809 cites W1495556840 @default.
- W2895946809 cites W1559566583 @default.
- W2895946809 cites W1564275273 @default.
- W2895946809 cites W1573829224 @default.
- W2895946809 cites W1574424832 @default.
- W2895946809 cites W1784426435 @default.
- W2895946809 cites W1790269988 @default.
- W2895946809 cites W1818335498 @default.
- W2895946809 cites W1827569473 @default.
- W2895946809 cites W1840872282 @default.
- W2895946809 cites W1874432494 @default.
- W2895946809 cites W1890608902 @default.
- W2895946809 cites W1894821366 @default.
- W2895946809 cites W1895514577 @default.
- W2895946809 cites W1913823824 @default.
- W2895946809 cites W1929360591 @default.
- W2895946809 cites W1936770188 @default.
- W2895946809 cites W1963492196 @default.
- W2895946809 cites W1963541777 @default.
- W2895946809 cites W1964220568 @default.
- W2895946809 cites W1964923925 @default.
- W2895946809 cites W1966652592 @default.
- W2895946809 cites W1967470122 @default.
- W2895946809 cites W1968051022 @default.
- W2895946809 cites W1968250682 @default.
- W2895946809 cites W1968303379 @default.
- W2895946809 cites W1968409580 @default.
- W2895946809 cites W1969706956 @default.
- W2895946809 cites W1970386735 @default.
- W2895946809 cites W1970713994 @default.
- W2895946809 cites W1971573052 @default.
- W2895946809 cites W1972689417 @default.
- W2895946809 cites W1972760976 @default.
- W2895946809 cites W1974055700 @default.
- W2895946809 cites W1974869899 @default.
- W2895946809 cites W1976348790 @default.
- W2895946809 cites W1979199696 @default.
- W2895946809 cites W1979784827 @default.
- W2895946809 cites W1981171898 @default.
- W2895946809 cites W1981998846 @default.
- W2895946809 cites W1982664961 @default.
- W2895946809 cites W1982934571 @default.
- W2895946809 cites W1983124736 @default.
- W2895946809 cites W1983402915 @default.
- W2895946809 cites W1986022717 @default.
- W2895946809 cites W1986225001 @default.
- W2895946809 cites W1988521206 @default.
- W2895946809 cites W1991133961 @default.
- W2895946809 cites W1991335360 @default.
- W2895946809 cites W1991643569 @default.
- W2895946809 cites W1993006648 @default.
- W2895946809 cites W1993639954 @default.
- W2895946809 cites W1994589849 @default.
- W2895946809 cites W1994662832 @default.
- W2895946809 cites W1995494201 @default.
- W2895946809 cites W1995660244 @default.
- W2895946809 cites W1996924444 @default.
- W2895946809 cites W1999720993 @default.
- W2895946809 cites W2000327471 @default.
- W2895946809 cites W2000617404 @default.
- W2895946809 cites W2001273789 @default.
- W2895946809 cites W2001937608 @default.
- W2895946809 cites W2002398307 @default.
- W2895946809 cites W2002514810 @default.
- W2895946809 cites W2007133754 @default.
- W2895946809 cites W2008570225 @default.
- W2895946809 cites W2008790997 @default.
- W2895946809 cites W2009344769 @default.
- W2895946809 cites W2009696224 @default.
- W2895946809 cites W2009808606 @default.
- W2895946809 cites W2010076702 @default.
- W2895946809 cites W2012765742 @default.
- W2895946809 cites W2012826587 @default.
- W2895946809 cites W2014171174 @default.
- W2895946809 cites W2014497947 @default.
- W2895946809 cites W2014750141 @default.
- W2895946809 cites W2017992778 @default.
- W2895946809 cites W2019717794 @default.
- W2895946809 cites W2021120412 @default.
- W2895946809 cites W2021126566 @default.
- W2895946809 cites W2021417089 @default.
- W2895946809 cites W2022333139 @default.
- W2895946809 cites W2022377416 @default.
- W2895946809 cites W2022745705 @default.
- W2895946809 cites W2024250498 @default.
- W2895946809 cites W2025448423 @default.
- W2895946809 cites W2025522134 @default.
- W2895946809 cites W2025733563 @default.
- W2895946809 cites W2026000814 @default.
- W2895946809 cites W2027304461 @default.