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- W2895949704 abstract "Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by abnormal protein accumulation, synaptic dysfunction, and cognitive impairment. The continuous increase in the incidence of AD with the aged population and mortality rate indicates the urgent need for establishing novel molecular targets for therapeutic potential. Peroxisome proliferator-activated receptor gamma (PPAR γ ) agonists such as rosiglitazone and pioglitazone reduce amyloid and tau pathologies, inhibit neuroinflammation, and improve memory impairments in several rodent models and in humans with mild-to-moderate AD. However, these agonists display poor blood brain barrier permeability resulting in inadequate bioavailability in the brain and thus requiring high dosing with chronic time frames. Furthermore, these dosing levels are associated with several adverse effects including increased incidence of weight gain, liver abnormalities, and heart failure. Therefore, there is a need for identifying novel compounds which target PPAR γ more selectively in the brain and could provide therapeutic benefits without a high incidence of adverse effects. This review focuses on how PPAR γ agonists influence various pathologies in AD with emphasis on development of novel selective PPAR γ modulators." @default.
- W2895949704 created "2018-10-26" @default.
- W2895949704 creator A5001159728 @default.
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- W2895949704 creator A5048015140 @default.
- W2895949704 creator A5062933766 @default.
- W2895949704 creator A5074520622 @default.
- W2895949704 date "2018-10-21" @default.
- W2895949704 modified "2023-10-05" @default.
- W2895949704 title "Signaling Mechanisms of Selective PPAR<i>γ</i> Modulators in Alzheimer’s Disease" @default.
- W2895949704 cites W1485300797 @default.
- W2895949704 cites W1494611500 @default.
- W2895949704 cites W149971845 @default.
- W2895949704 cites W1503023999 @default.
- W2895949704 cites W1527827101 @default.
- W2895949704 cites W1543788907 @default.
- W2895949704 cites W1567503997 @default.
- W2895949704 cites W1605023308 @default.
- W2895949704 cites W1633340712 @default.
- W2895949704 cites W1639924204 @default.
- W2895949704 cites W1711248712 @default.
- W2895949704 cites W1811830477 @default.
- W2895949704 cites W1886575365 @default.
- W2895949704 cites W1896225205 @default.
- W2895949704 cites W1953508171 @default.
- W2895949704 cites W1964876127 @default.
- W2895949704 cites W1970060454 @default.
- W2895949704 cites W1970613754 @default.
- W2895949704 cites W1971371724 @default.
- W2895949704 cites W1972952831 @default.
- W2895949704 cites W1974266381 @default.
- W2895949704 cites W1976619844 @default.
- W2895949704 cites W1978999542 @default.
- W2895949704 cites W1980660426 @default.
- W2895949704 cites W1982886546 @default.
- W2895949704 cites W1983006621 @default.
- W2895949704 cites W1983670592 @default.
- W2895949704 cites W1984200333 @default.
- W2895949704 cites W1984636592 @default.
- W2895949704 cites W1986245376 @default.
- W2895949704 cites W1987248538 @default.
- W2895949704 cites W1990293508 @default.
- W2895949704 cites W1992491411 @default.
- W2895949704 cites W1992808568 @default.
- W2895949704 cites W1992830187 @default.
- W2895949704 cites W1994311239 @default.
- W2895949704 cites W1994554610 @default.
- W2895949704 cites W1995354490 @default.
- W2895949704 cites W1995398218 @default.
- W2895949704 cites W1995491925 @default.
- W2895949704 cites W1995562130 @default.
- W2895949704 cites W1997304834 @default.
- W2895949704 cites W1997822484 @default.
- W2895949704 cites W1998788702 @default.
- W2895949704 cites W1998933601 @default.
- W2895949704 cites W1999546189 @default.
- W2895949704 cites W1999856629 @default.
- W2895949704 cites W2001155412 @default.
- W2895949704 cites W2001156075 @default.
- W2895949704 cites W2001210466 @default.
- W2895949704 cites W2001863716 @default.
- W2895949704 cites W2002937059 @default.
- W2895949704 cites W2006005044 @default.
- W2895949704 cites W2006505402 @default.
- W2895949704 cites W2007336029 @default.
- W2895949704 cites W2009170266 @default.
- W2895949704 cites W2010037905 @default.
- W2895949704 cites W2010156024 @default.
- W2895949704 cites W2010233543 @default.
- W2895949704 cites W2012225322 @default.
- W2895949704 cites W2012818636 @default.
- W2895949704 cites W2015620326 @default.
- W2895949704 cites W2015721847 @default.
- W2895949704 cites W2017079501 @default.
- W2895949704 cites W2021335916 @default.
- W2895949704 cites W2021758696 @default.
- W2895949704 cites W2022048961 @default.
- W2895949704 cites W2028903661 @default.
- W2895949704 cites W2030270894 @default.
- W2895949704 cites W2030623266 @default.
- W2895949704 cites W2031919883 @default.
- W2895949704 cites W2033726284 @default.
- W2895949704 cites W2035825704 @default.
- W2895949704 cites W2042200036 @default.
- W2895949704 cites W2042211739 @default.
- W2895949704 cites W2044257521 @default.
- W2895949704 cites W2044782567 @default.
- W2895949704 cites W2046604129 @default.
- W2895949704 cites W2046886830 @default.
- W2895949704 cites W2049771698 @default.
- W2895949704 cites W2049871798 @default.
- W2895949704 cites W2051978635 @default.
- W2895949704 cites W2053756526 @default.
- W2895949704 cites W2054115426 @default.
- W2895949704 cites W2054685711 @default.
- W2895949704 cites W2057042201 @default.
- W2895949704 cites W2057530150 @default.