Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895951335> ?p ?o ?g. }
- W2895951335 abstract "Over the past two decades, immune cell therapy has emerged as a potent treatment for multiple cancers, first through groundbreaking leukemia therapy, and more recently, by tackling solid tumors. Developing successful therapeutic strategies using live cells could benefit from the ability to rapidly determine their in vivo biodistribution and persistence. Assaying cell biodistribution is unconventional compared to traditional small molecule drug pharmacokinetic readouts used in the pharmaceutical pipeline, yet this information is critical towards understanding putative therapeutic outcomes and modes of action. Towards this goal, efforts are underway to visualize and quantify immune cell therapy in vivo using advanced magnetic resonance imaging (MRI) techniques. Cell labeling probes based on perfluorocarbon nanoemulsions, paired with fluorine-19 MRI detection, enables background-free quantification of cell localization and survival. Here, we highlight recent preclinical and clinical uses of perfluorocarbon probes and 19F MRI for adoptive cell transfer (ACT) studies employing experimental T lymphocytes, NK, PBMC, and dendritic cell therapies. We assess the forward looking potential of this emerging imaging technology to aid discovery and preclinical phases, as well as clinical trials. The limitations and barriers towards widespread adoption of this technology, as well as alternative imaging strategies, are discussed." @default.
- W2895951335 created "2018-10-26" @default.
- W2895951335 creator A5018015750 @default.
- W2895951335 creator A5025533535 @default.
- W2895951335 creator A5054397260 @default.
- W2895951335 date "2018-10-11" @default.
- W2895951335 modified "2023-10-15" @default.
- W2895951335 title "Fluorine-19 MRI for detection and quantification of immune cell therapy for cancer" @default.
- W2895951335 cites W104234931 @default.
- W2895951335 cites W128324678 @default.
- W2895951335 cites W1483658104 @default.
- W2895951335 cites W1551006141 @default.
- W2895951335 cites W1916675606 @default.
- W2895951335 cites W1945062032 @default.
- W2895951335 cites W1972252386 @default.
- W2895951335 cites W1972494701 @default.
- W2895951335 cites W1974410840 @default.
- W2895951335 cites W1979835594 @default.
- W2895951335 cites W1981054482 @default.
- W2895951335 cites W1982789496 @default.
- W2895951335 cites W1983818829 @default.
- W2895951335 cites W1984200978 @default.
- W2895951335 cites W1985330755 @default.
- W2895951335 cites W1987253270 @default.
- W2895951335 cites W1988694820 @default.
- W2895951335 cites W1988942415 @default.
- W2895951335 cites W1992430391 @default.
- W2895951335 cites W1994960978 @default.
- W2895951335 cites W2001914901 @default.
- W2895951335 cites W2007805079 @default.
- W2895951335 cites W2008182044 @default.
- W2895951335 cites W2016198530 @default.
- W2895951335 cites W2026043031 @default.
- W2895951335 cites W2026404635 @default.
- W2895951335 cites W2028417270 @default.
- W2895951335 cites W2029411020 @default.
- W2895951335 cites W2031745114 @default.
- W2895951335 cites W2033107552 @default.
- W2895951335 cites W2035435963 @default.
- W2895951335 cites W2037885917 @default.
- W2895951335 cites W2043350471 @default.
- W2895951335 cites W2045883564 @default.
- W2895951335 cites W2046972425 @default.
- W2895951335 cites W2051927560 @default.
- W2895951335 cites W2053661002 @default.
- W2895951335 cites W2058205936 @default.
- W2895951335 cites W2061703101 @default.
- W2895951335 cites W2063604248 @default.
- W2895951335 cites W2067271886 @default.
- W2895951335 cites W2075278894 @default.
- W2895951335 cites W2080613443 @default.
- W2895951335 cites W2084946368 @default.
- W2895951335 cites W2088925558 @default.
- W2895951335 cites W2089751534 @default.
- W2895951335 cites W2098219449 @default.
- W2895951335 cites W2101501385 @default.
- W2895951335 cites W2101585919 @default.
- W2895951335 cites W2103959341 @default.
- W2895951335 cites W2104372315 @default.
- W2895951335 cites W2104802770 @default.
- W2895951335 cites W2104898472 @default.
- W2895951335 cites W2119207148 @default.
- W2895951335 cites W2124169195 @default.
- W2895951335 cites W2125711934 @default.
- W2895951335 cites W2127215370 @default.
- W2895951335 cites W2139192453 @default.
- W2895951335 cites W2157297527 @default.
- W2895951335 cites W2166921498 @default.
- W2895951335 cites W2181134504 @default.
- W2895951335 cites W2189471921 @default.
- W2895951335 cites W2204420463 @default.
- W2895951335 cites W2224005134 @default.
- W2895951335 cites W2293288999 @default.
- W2895951335 cites W2294877715 @default.
- W2895951335 cites W2335365056 @default.
- W2895951335 cites W2336629139 @default.
- W2895951335 cites W2411323646 @default.
- W2895951335 cites W2416176993 @default.
- W2895951335 cites W2417420516 @default.
- W2895951335 cites W2463565180 @default.
- W2895951335 cites W2471856449 @default.
- W2895951335 cites W2515679023 @default.
- W2895951335 cites W2531581021 @default.
- W2895951335 cites W2536829922 @default.
- W2895951335 cites W2537482643 @default.
- W2895951335 cites W2587162824 @default.
- W2895951335 cites W2611333272 @default.
- W2895951335 cites W2617230784 @default.
- W2895951335 cites W2738678436 @default.
- W2895951335 cites W2767588992 @default.
- W2895951335 cites W2775108371 @default.
- W2895951335 cites W2782764016 @default.
- W2895951335 cites W4210531554 @default.
- W2895951335 cites W2767089232 @default.
- W2895951335 doi "https://doi.org/10.1186/s40425-018-0416-9" @default.
- W2895951335 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6180584" @default.
- W2895951335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30305175" @default.
- W2895951335 hasPublicationYear "2018" @default.
- W2895951335 type Work @default.
- W2895951335 sameAs 2895951335 @default.