FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895951641> ?p ?o ?g. }

• W2895951641 abstract "Triggering or enhancing antitumor activity of tumor-associated macrophages is an attractive strategy for cancer treatment. We have previously shown that the cytokine interferon- (IFN-), a type II IFN, could synergize with Toll-like receptor (TLR) agonists for induction of antitumor M1 macrophages. However, the toxicity of IFN- limits its clinical use. Here, we investigated whether the less toxic type I IFNs, IFN- and IFN-, could potentially replace IFN- for induction of antitumor M1 macrophages. We measured in vitro the ability of type I and II IFNs to synergize with TLR agonists for transcription of inducible nitric oxide synthase (iNOS) mRNA and secretion of nitric oxide (NO) by mouse bone marrow-derived macrophages (BMDMs). An in vitro growth inhibition assay was used to measure both cytotoxic and cytostatic activity of activated macrophages against Lewis lung carcinoma (LLC) cancer cells. We found that both type I and II IFNs could synergize with TLR agonists in inducing macrophage-mediated inhibition of cancer cell growth, which was dependent on NO. The ability of high dose lipopolysaccharide (LPS) to induce tumoricidal activity in macrophages in the absence of IFN- was shown to depend on induction of autocrine type I IFNs. Antitumor M1 macrophages could also be generated in the absence of IFN- by a combination of two TLR ligands when using the TLR3 agonist poly(I:C) which induces autocrine type I IFNs. Finally, we show that encapsulation of poly(I:C) into nanoparticles improved its potency to induce M1 macrophages up to 100-fold. This study reveals the potential of type I IFNs for activation of antitumor macrophages and indicates new avenues for cancer immunotherapy based on type I IFN signaling, including combination of TLR agonists." @default.
• W2895951641 created "2018-10-26" @default.
• W2895951641 creator A5046375782 @default.
• W2895951641 creator A5047041645 @default.
• W2895951641 creator A5049984780 @default.
• W2895951641 creator A5050011594 @default.
• W2895951641 creator A5058387805 @default.
• W2895951641 creator A5074089901 @default.
• W2895951641 creator A5084475310 @default.
• W2895951641 date "2018-11-02" @default.
• W2895951641 modified "2023-10-14" @default.
• W2895951641 title "Both Type I and Type II Interferons Can Activate Antitumor M1 Macrophages When Combined With TLR Stimulation" @default.
• W2895951641 cites W1496717884 @default.
• W2895951641 cites W1544940894 @default.
• W2895951641 cites W1566335138 @default.
• W2895951641 cites W1578257252 @default.
• W2895951641 cites W1587144004 @default.
• W2895951641 cites W1642873092 @default.
• W2895951641 cites W1863664917 @default.
• W2895951641 cites W1925210413 @default.
• W2895951641 cites W1967269498 @default.
• W2895951641 cites W1967739146 @default.
• W2895951641 cites W1967890713 @default.
• W2895951641 cites W1969342260 @default.
• W2895951641 cites W1971620413 @default.
• W2895951641 cites W1992000721 @default.
• W2895951641 cites W1994303699 @default.
• W2895951641 cites W2004829503 @default.
• W2895951641 cites W2022244055 @default.
• W2895951641 cites W2033058856 @default.
• W2895951641 cites W2034913211 @default.
• W2895951641 cites W2040233810 @default.
• W2895951641 cites W2040549937 @default.
• W2895951641 cites W2041702921 @default.
• W2895951641 cites W2043991982 @default.
• W2895951641 cites W2044873081 @default.
• W2895951641 cites W2048455086 @default.
• W2895951641 cites W2050161362 @default.
• W2895951641 cites W2050283646 @default.
• W2895951641 cites W2052391094 @default.
• W2895951641 cites W2056241473 @default.
• W2895951641 cites W2058702124 @default.
• W2895951641 cites W2066847273 @default.
• W2895951641 cites W2072321567 @default.
• W2895951641 cites W2072668724 @default.
• W2895951641 cites W2080083579 @default.
• W2895951641 cites W2080583018 @default.
• W2895951641 cites W2083070181 @default.
• W2895951641 cites W2083569783 @default.
• W2895951641 cites W2094139192 @default.
• W2895951641 cites W2096015727 @default.
• W2895951641 cites W2096496652 @default.
• W2895951641 cites W2101195992 @default.
• W2895951641 cites W2109445380 @default.
• W2895951641 cites W2110644189 @default.
• W2895951641 cites W2111228548 @default.
• W2895951641 cites W2115185894 @default.
• W2895951641 cites W2116667526 @default.
• W2895951641 cites W2130421043 @default.
• W2895951641 cites W2141753982 @default.
• W2895951641 cites W2150627012 @default.
• W2895951641 cites W2163175900 @default.
• W2895951641 cites W2163212927 @default.
• W2895951641 cites W2192049920 @default.
• W2895951641 cites W2256675122 @default.
• W2895951641 cites W2275249553 @default.
• W2895951641 cites W2328901916 @default.
• W2895951641 cites W2528746546 @default.
• W2895951641 cites W2591627715 @default.
• W2895951641 cites W2625574648 @default.
• W2895951641 cites W2763570319 @default.
• W2895951641 cites W2765367127 @default.
• W2895951641 cites W2770048086 @default.
• W2895951641 cites W61522056 @default.
• W2895951641 doi "https://doi.org/10.3389/fimmu.2018.02520" @default.
• W2895951641 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6224375" @default.
• W2895951641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30450098" @default.
• W2895951641 hasPublicationYear "2018" @default.
• W2895951641 type Work @default.
• W2895951641 sameAs 2895951641 @default.
• W2895951641 citedByCount "65" @default.
• W2895951641 countsByYear W28959516412019 @default.
• W2895951641 countsByYear W28959516412020 @default.
• W2895951641 countsByYear W28959516412021 @default.
• W2895951641 countsByYear W28959516412022 @default.
• W2895951641 countsByYear W28959516412023 @default.
• W2895951641 crossrefType "journal-article" @default.
• W2895951641 hasAuthorship W2895951641A5046375782 @default.
• W2895951641 hasAuthorship W2895951641A5047041645 @default.
• W2895951641 hasAuthorship W2895951641A5049984780 @default.
• W2895951641 hasAuthorship W2895951641A5050011594 @default.
• W2895951641 hasAuthorship W2895951641A5058387805 @default.
• W2895951641 hasAuthorship W2895951641A5074089901 @default.
• W2895951641 hasAuthorship W2895951641A5084475310 @default.
• W2895951641 hasBestOaLocation W28959516411 @default.
• W2895951641 hasConcept C121608353 @default.
• W2895951641 hasConcept C128240485 @default.
• W2895951641 hasConcept C134018914 @default.
• W2895951641 hasConcept C136449434 @default.
• W2895951641 hasConcept C154317977 @default.

• next