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• W2895953071 abstract "Neurons of the CNS elaborate highly branched dendritic arbors that host numerous dendritic spines, which serve as the postsynaptic platform for most excitatory synapses. The actin cytoskeleton plays an important role in dendrite development and spine formation, but the underlying mechanisms remain incompletely understood. Tropomodulins (Tmods) are a family of actin-binding proteins that cap the slow-growing (pointed) end of actin filaments, thereby regulating the stability, length, and architecture of complex actin networks in diverse cell types. Three members of the Tmod family, Tmod1, Tmod2, and Tmod3 are expressed in the vertebrate CNS, but their function in neuronal development is largely unknown. In this study, we present evidence that Tmod1 and Tmod2 exhibit distinct roles in regulating spine development and dendritic arborization, respectively. Using rat hippocampal tissues from both sexes, we find that Tmod1 and Tmod2 are expressed with distinct developmental profiles: Tmod2 is expressed early during hippocampal development, whereas Tmod1 expression coincides with synaptogenesis. We then show that knockdown of Tmod2, but not Tmod1, severely impairs dendritic branching. Both Tmod1 and Tmod2 are localized to a distinct subspine region where they regulate local F-actin stability. However, the knockdown of Tmod1, but not Tmod2, disrupts spine morphogenesis and impairs synapse formation. Collectively, these findings demonstrate that regulation of the actin cytoskeleton by different members of the Tmod family plays an important role in distinct aspects of dendrite and spine development.SIGNIFICANCE STATEMENT The Tropomodulin family of molecules is best known for controlling the length and stability of actin myofilaments in skeletal muscles. While several Tropomodulin members are expressed in the brain, fundamental knowledge about their role in neuronal function is limited. In this study, we show the unique expression profile and subcellular distribution of Tmod1 and Tmod2 in hippocampal neurons. While both Tmod1 and Tmod2 regulate F-actin stability, we find that they exhibit isoform-specific roles in dendrite development and synapse formation: Tmod2 regulates dendritic arborization, whereas Tmod1 is required for spine development and synapse formation. These findings provide novel insight into the actin regulatory mechanisms underlying neuronal development, thereby shedding light on potential pathways disrupted in a number of neurological disorders." @default.
• W2895953071 created "2018-10-26" @default.
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• W2895953071 date "2018-10-09" @default.
• W2895953071 modified "2023-10-10" @default.
• W2895953071 title "Tropomodulin Isoform-Specific Regulation of Dendrite Development and Synapse Formation" @default.
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• W2895953071 cites W1965606484 @default.
• W2895953071 cites W1977048250 @default.
• W2895953071 cites W1980581068 @default.
• W2895953071 cites W1987774571 @default.
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• W2895953071 cites W1995852646 @default.
• W2895953071 cites W1998585323 @default.
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• W2895953071 cites W2011734517 @default.
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• W2895953071 cites W2015982738 @default.
• W2895953071 cites W2022057141 @default.
• W2895953071 cites W2028776035 @default.
• W2895953071 cites W2031330093 @default.
• W2895953071 cites W2031516445 @default.
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• W2895953071 doi "https://doi.org/10.1523/jneurosci.3325-17.2018" @default.
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