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- W2895955101 abstract "Increasing evidence suggests a role for the immune system to finely tune metabolic homeostasis. The possibility that the immune system can likewise regulate islet endocrine function has only commenced drawing attention. Islet beta cells are the main producers of insulin and have to dynamically respond to fluctuating insulin demands of the body. While inflammation has long been considered as an important pathogenic feature of diabetes development, pioneer studies have shown that immune cells reside inside pancreatic islets under steady state and that components of the immune system can promote beta cell insulin production. The present review will thus highlight the recent research on specific immune pathways regulating beta cell function discussing the beneficial influence of innate immune cells." @default.
- W2895955101 created "2018-10-26" @default.
- W2895955101 creator A5068532006 @default.
- W2895955101 date "2019-02-01" @default.
- W2895955101 modified "2023-10-16" @default.
- W2895955101 title "Innate immune priming of insulin secretion" @default.
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- W2895955101 doi "https://doi.org/10.1016/j.coi.2018.10.005" @default.
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