FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895955223> ?p ?o ?g. }

• W2895955223 endingPage "286" @default.
• W2895955223 startingPage "285" @default.
• W2895955223 abstract "We read with interest the article from Lee et al1Lee B.P. et al.Gastroenterology. 2018; 155: 422-430 e1Abstract Full Text Full Text PDF PubMed Scopus (192) Google Scholar about early liver transplantation for severe alcoholic hepatitis. We compliment them for their exhaustive collection of data on patients transplanted for alcoholic hepatitis across the United States in the retrospective ACCELARATE-AH study. We would like to add some comments that may contribute to the debate on this hot topic. First, in this study, a liver biopsy was not systematically performed, as it should preferably have been.2Singal A.K. et al.Am J Gastroenterol. 2018; 113: 175-194Crossref PubMed Scopus (358) Google Scholar The fact that alcoholic hepatitis was observed on the liver explant in only 59% of the cases (vs 100% in the landmark study from Mathurin et al3Mathurin P. et al.N Engl J Med. 2011; 365: 1790-1800Crossref PubMed Scopus (611) Google Scholar) strongly suggests that a significant proportion of patients were transplanted for decompensated cirrhosis without alcoholic hepatitis, which made the study population heterogeneous. Whether this heterogeneity in the study population explains the surprisingly high rates of survival is a matter of debate. Second, as the authors acknowledged, the rate of any alcohol relapse was higher in their study than in Mathurin et al study,3Mathurin P. et al.N Engl J Med. 2011; 365: 1790-1800Crossref PubMed Scopus (611) Google Scholar as well as in other studies using stringent criteria for patient selection. This observation was also made in a recent meta-analysis of trials evaluating alcohol relapse after liver transplantation among patients with alcoholic hepatitis.4Marot A. et al.PLoS One. 2018; 13: e0190823Crossref PubMed Scopus (56) Google Scholar This meta-analysis (which also included some patients from the Lee et al study) observed a substantial decrease in rates of alcohol relapse when only studies that used a stringent selection process for deciding which patients should be transplanted were selected. In the subgroup analysis that included only patients transplanted for clinically severe alcoholic hepatitis and that did not include studies that did not use stringent criteria for selecting candidates for liver transplantation (patients motivated to stay abstinent from alcohol after liver transplantation, good psychosocial support, and/or a favorable patient psychological profile), only 14% of patients had alcohol relapse after liver transplantation (95% confidence interval, 0.08–0.23). No heterogeneity was identified in this analysis (P = .6; I2 = 0%), which is a strong indicator of confidence in these results. Thus, these stringent criteria should be used to select patients with a low risk of alcohol relapse after liver transplantation. Avoiding alcohol relapse after liver transplantation is a major issue because patients who relapse after liver transplantation usually return to harmful drinking patterns (pooled estimate rate in the recent meta-analysis, 0.15; 95% confidence interval, 0.07–0.27; I2 = 3%4Marot A. et al.PLoS One. 2018; 13: e0190823Crossref PubMed Scopus (56) Google Scholar) and, as Lee et al1Lee B.P. et al.Gastroenterology. 2018; 155: 422-430 e1Abstract Full Text Full Text PDF PubMed Scopus (192) Google Scholar and others5Dumortier J. et al.Am J Gastroenterol. 2015; 110 (quiz 1167): 1160-1166Crossref PubMed Scopus (94) Google Scholar have highlighted, patients with significant alcohol relapse have decreased survival rates. Furthermore, as the use of liver transplantation for patients with severe alcoholic hepatitis is gaining interest, the application of a strict selection process will help to avoid any problems of equity in liver graft allocation.6Donckier V. et al.J Hepatol. 2014; 60: 866-871Abstract Full Text Full Text PDF PubMed Scopus (74) Google Scholar This conservative strategy for patient selection will contribute to the continued adoption of severe alcoholic hepatitis not responsive to medical therapy as a new indication for liver transplantation by public opinion and healthcare providers.7Artru F. et al.Liver Int. 2017; 37: 337-339Crossref PubMed Scopus (26) Google Scholar Overall, Lee et al provide additional evidence that prospective studies aimed at identifying factors predicting alcohol relapse after liver transplantation are urgently needed. The first results of an ongoing prospective trial with the primary goal of assessing alcohol relapse after liver transplantation (NCT01756794) are expected at the end of 2018 and will be of interest. Outcomes of Early Liver Transplantation for Patients With Severe Alcoholic HepatitisGastroenterologyVol. 155Issue 2PreviewThe American Consortium of Early Liver Transplantation for Alcoholic Hepatitis comprises 12 centers from 8 United Network for Organ Sharing regions studying early liver transplantation (LT) (without mandated period of sobriety) for patients with severe alcoholic hepatitis (AH). We analyzed the outcomes of these patients. Full-Text PDF ReplyGastroenterologyVol. 156Issue 1PreviewWe thank Solga et al and Deltenre et al for their interest in ACCELERATE-AH. We offer the following points in reply. Full-Text PDF" @default.
• W2895955223 created "2018-10-26" @default.
• W2895955223 creator A5004209196 @default.
• W2895955223 creator A5061193855 @default.
• W2895955223 creator A5070860490 @default.
• W2895955223 date "2019-01-01" @default.
• W2895955223 modified "2023-10-18" @default.
• W2895955223 title "Outcomes After Early Liver Transplantation for Patients With Severe Alcoholic Hepatitis: Additional Evidence From a Meta-analysis" @default.
• W2895955223 cites W1950458387 @default.
• W2895955223 cites W2007258272 @default.
• W2895955223 cites W2016730576 @default.
• W2895955223 cites W2594352786 @default.
• W2895955223 cites W2784039673 @default.
• W2895955223 cites W2798002075 @default.
• W2895955223 doi "https://doi.org/10.1053/j.gastro.2018.09.057" @default.
• W2895955223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30315775" @default.
• W2895955223 hasPublicationYear "2019" @default.
• W2895955223 type Work @default.
• W2895955223 sameAs 2895955223 @default.
• W2895955223 citedByCount "0" @default.
• W2895955223 crossrefType "journal-article" @default.
• W2895955223 hasAuthorship W2895955223A5004209196 @default.
• W2895955223 hasAuthorship W2895955223A5061193855 @default.
• W2895955223 hasAuthorship W2895955223A5070860490 @default.
• W2895955223 hasBestOaLocation W28959552231 @default.
• W2895955223 hasConcept C126322002 @default.
• W2895955223 hasConcept C17744445 @default.
• W2895955223 hasConcept C199539241 @default.
• W2895955223 hasConcept C2775934546 @default.
• W2895955223 hasConcept C2776029263 @default.
• W2895955223 hasConcept C2776455275 @default.
• W2895955223 hasConcept C2777214474 @default.
• W2895955223 hasConcept C2777575235 @default.
• W2895955223 hasConcept C2777766500 @default.
• W2895955223 hasConcept C2779473830 @default.
• W2895955223 hasConcept C2779609443 @default.
• W2895955223 hasConcept C2780732942 @default.
• W2895955223 hasConcept C2908647359 @default.
• W2895955223 hasConcept C2911091166 @default.
• W2895955223 hasConcept C71924100 @default.
• W2895955223 hasConcept C83867959 @default.
• W2895955223 hasConcept C90924648 @default.
• W2895955223 hasConcept C99454951 @default.
• W2895955223 hasConceptScore W2895955223C126322002 @default.
• W2895955223 hasConceptScore W2895955223C17744445 @default.
• W2895955223 hasConceptScore W2895955223C199539241 @default.
• W2895955223 hasConceptScore W2895955223C2775934546 @default.
• W2895955223 hasConceptScore W2895955223C2776029263 @default.
• W2895955223 hasConceptScore W2895955223C2776455275 @default.
• W2895955223 hasConceptScore W2895955223C2777214474 @default.
• W2895955223 hasConceptScore W2895955223C2777575235 @default.
• W2895955223 hasConceptScore W2895955223C2777766500 @default.
• W2895955223 hasConceptScore W2895955223C2779473830 @default.
• W2895955223 hasConceptScore W2895955223C2779609443 @default.
• W2895955223 hasConceptScore W2895955223C2780732942 @default.
• W2895955223 hasConceptScore W2895955223C2908647359 @default.
• W2895955223 hasConceptScore W2895955223C2911091166 @default.
• W2895955223 hasConceptScore W2895955223C71924100 @default.
• W2895955223 hasConceptScore W2895955223C83867959 @default.
• W2895955223 hasConceptScore W2895955223C90924648 @default.
• W2895955223 hasConceptScore W2895955223C99454951 @default.
• W2895955223 hasIssue "1" @default.
• W2895955223 hasLocation W28959552231 @default.
• W2895955223 hasLocation W28959552232 @default.
• W2895955223 hasOpenAccess W2895955223 @default.
• W2895955223 hasPrimaryLocation W28959552231 @default.
• W2895955223 hasRelatedWork W159518723 @default.
• W2895955223 hasRelatedWork W1771158870 @default.
• W2895955223 hasRelatedWork W1973718569 @default.
• W2895955223 hasRelatedWork W2062320843 @default.
• W2895955223 hasRelatedWork W2084811395 @default.
• W2895955223 hasRelatedWork W2119148197 @default.
• W2895955223 hasRelatedWork W2153568700 @default.
• W2895955223 hasRelatedWork W2414938662 @default.
• W2895955223 hasRelatedWork W2473309788 @default.
• W2895955223 hasRelatedWork W2915032079 @default.
• W2895955223 hasVolume "156" @default.
• W2895955223 isParatext "false" @default.
• W2895955223 isRetracted "false" @default.
• W2895955223 magId "2895955223" @default.
• W2895955223 workType "article" @default.