Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895957069> ?p ?o ?g. }
- W2895957069 endingPage "108" @default.
- W2895957069 startingPage "100" @default.
- W2895957069 abstract "A new Dichlorotetra(4-hydroxy-N′-(pyridin-4-ylmethylene)benzohydrazone)Ru(II) complex 1 has been synthesized and characterized using spectroscopic techniques. The structure of complex 1 has been optimized through ORCA computational programme package using B3LYP functionals. The complex binds efficiently with calf thymus DNA (CT-DNA) as monitored by UV–visible titrations (Kb = 4.8 × 105), ethidium bromide displacement studies (Ksv = 1.39) as well as Circular Dichroism (CD) titrations. The complex intercalates with DNA base pairs. It shows cleavage of supercoiled (SC) DNA into nicked circular (NC) DNA efficiently via oxidative pathway. Complex 1 also inhibits Topoisomerase I (Topo I) relaxation activity at concentration < 20 μM. The molecular docking studies support that Topo I inhibition occur via blocking religation of G11 hydroxyl group." @default.
- W2895957069 created "2018-10-26" @default.
- W2895957069 creator A5072174538 @default.
- W2895957069 creator A5081438388 @default.
- W2895957069 date "2019-02-01" @default.
- W2895957069 modified "2023-10-06" @default.
- W2895957069 title "A combined experimental and theoretical investigation of ruthenium(II)-hydrazone complex with DNA: Spectroscopic, nuclease activity, topoisomerase inhibition and molecular docking" @default.
- W2895957069 cites W1978334235 @default.
- W2895957069 cites W1988091937 @default.
- W2895957069 cites W1989807773 @default.
- W2895957069 cites W2004681801 @default.
- W2895957069 cites W2010691080 @default.
- W2895957069 cites W2015723183 @default.
- W2895957069 cites W2023271753 @default.
- W2895957069 cites W2037045908 @default.
- W2895957069 cites W2041212563 @default.
- W2895957069 cites W2041902549 @default.
- W2895957069 cites W2042062103 @default.
- W2895957069 cites W2044851985 @default.
- W2895957069 cites W2045236580 @default.
- W2895957069 cites W2048036931 @default.
- W2895957069 cites W2048447619 @default.
- W2895957069 cites W2058210956 @default.
- W2895957069 cites W2060078670 @default.
- W2895957069 cites W2061953872 @default.
- W2895957069 cites W2067718414 @default.
- W2895957069 cites W2068690697 @default.
- W2895957069 cites W2070635871 @default.
- W2895957069 cites W2078146328 @default.
- W2895957069 cites W2082106291 @default.
- W2895957069 cites W2092157292 @default.
- W2895957069 cites W2094478102 @default.
- W2895957069 cites W2116177049 @default.
- W2895957069 cites W2119547517 @default.
- W2895957069 cites W2125790166 @default.
- W2895957069 cites W2139385164 @default.
- W2895957069 cites W2150829534 @default.
- W2895957069 cites W2159100925 @default.
- W2895957069 cites W2162764839 @default.
- W2895957069 cites W2167361192 @default.
- W2895957069 cites W22904654 @default.
- W2895957069 cites W2328411799 @default.
- W2895957069 cites W2534448760 @default.
- W2895957069 cites W2559115459 @default.
- W2895957069 cites W2730569171 @default.
- W2895957069 cites W2789388339 @default.
- W2895957069 cites W2811205212 @default.
- W2895957069 cites W2950416424 @default.
- W2895957069 cites W2952345937 @default.
- W2895957069 cites W4211092410 @default.
- W2895957069 cites W4236530034 @default.
- W2895957069 cites W4251754471 @default.
- W2895957069 doi "https://doi.org/10.1016/j.saa.2018.10.035" @default.
- W2895957069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30384015" @default.
- W2895957069 hasPublicationYear "2019" @default.
- W2895957069 type Work @default.
- W2895957069 sameAs 2895957069 @default.
- W2895957069 citedByCount "7" @default.
- W2895957069 countsByYear W28959570692020 @default.
- W2895957069 countsByYear W28959570692021 @default.
- W2895957069 countsByYear W28959570692023 @default.
- W2895957069 crossrefType "journal-article" @default.
- W2895957069 hasAuthorship W2895957069A5072174538 @default.
- W2895957069 hasAuthorship W2895957069A5081438388 @default.
- W2895957069 hasConcept C133571119 @default.
- W2895957069 hasConcept C137824038 @default.
- W2895957069 hasConcept C147897179 @default.
- W2895957069 hasConcept C158456008 @default.
- W2895957069 hasConcept C159110408 @default.
- W2895957069 hasConcept C161790260 @default.
- W2895957069 hasConcept C178790620 @default.
- W2895957069 hasConcept C185581394 @default.
- W2895957069 hasConcept C185592680 @default.
- W2895957069 hasConcept C2776907736 @default.
- W2895957069 hasConcept C2777271071 @default.
- W2895957069 hasConcept C2780349576 @default.
- W2895957069 hasConcept C41685203 @default.
- W2895957069 hasConcept C552990157 @default.
- W2895957069 hasConcept C55493867 @default.
- W2895957069 hasConcept C555196967 @default.
- W2895957069 hasConcept C71240020 @default.
- W2895957069 hasConcept C71924100 @default.
- W2895957069 hasConcept C73573662 @default.
- W2895957069 hasConcept C8010536 @default.
- W2895957069 hasConceptScore W2895957069C133571119 @default.
- W2895957069 hasConceptScore W2895957069C137824038 @default.
- W2895957069 hasConceptScore W2895957069C147897179 @default.
- W2895957069 hasConceptScore W2895957069C158456008 @default.
- W2895957069 hasConceptScore W2895957069C159110408 @default.
- W2895957069 hasConceptScore W2895957069C161790260 @default.
- W2895957069 hasConceptScore W2895957069C178790620 @default.
- W2895957069 hasConceptScore W2895957069C185581394 @default.
- W2895957069 hasConceptScore W2895957069C185592680 @default.
- W2895957069 hasConceptScore W2895957069C2776907736 @default.
- W2895957069 hasConceptScore W2895957069C2777271071 @default.
- W2895957069 hasConceptScore W2895957069C2780349576 @default.
- W2895957069 hasConceptScore W2895957069C41685203 @default.
- W2895957069 hasConceptScore W2895957069C552990157 @default.