FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895961551> ?p ?o ?g. }

• W2895961551 abstract "Abstract Skeletal muscle is an archetypal organ whose structure is tuned to match function. The magnitude of order in muscle fibers and myofibrils containing motor protein polymers determines the directed force output of the summed force vectors and, therefore, the muscle’s power performance on the structural level. Structure and function can change dramatically during disease states involving chronic remodeling. Cellular remodeling of the cytoarchitecture has been pursued using noninvasive and label-free multiphoton second harmonic generation (SHG) microscopy. Hereby, structure parameters can be extracted as a measure of myofibrillar order and thus are suggestive of the force output that a remodeled structure can still achieve. However, to date, the parameters have only been an indirect measure, and a precise calibration of optical SHG assessment for an exerted force has been elusive as no technology in existence correlates these factors. We engineered a novel, automated, high-precision biomechatronics system into a multiphoton microscope allows simultaneous isometric Ca 2+ -graded force or passive viscoelasticity measurements and SHG recordings. Using this MechaMorph system, we studied force and SHG in single EDL muscle fibers from wt and mdx mice; the latter serves as a model for compromised force and abnormal myofibrillar structure. We present Ca 2+ -graded isometric force, pCa-force curves, passive viscoelastic parameters and 3D structure in the same fiber for the first time. Furthermore, we provide a direct calibration of isometric force to morphology, which allows noninvasive prediction of the force output of single fibers from only multiphoton images, suggesting a potential application in the diagnosis of myopathies." @default.
• W2895961551 created "2018-10-26" @default.
• W2895961551 creator A5007241569 @default.
• W2895961551 creator A5041892010 @default.
• W2895961551 creator A5055086920 @default.
• W2895961551 creator A5061950718 @default.
• W2895961551 creator A5067297209 @default.
• W2895961551 creator A5070548943 @default.
• W2895961551 creator A5071837046 @default.
• W2895961551 date "2018-10-24" @default.
• W2895961551 modified "2023-10-14" @default.
• W2895961551 title "Optical prediction of single muscle fiber force production using a combined biomechatronics and second harmonic generation imaging approach" @default.
• W2895961551 cites W1941910566 @default.
• W2895961551 cites W1963773457 @default.
• W2895961551 cites W1968612373 @default.
• W2895961551 cites W1969922725 @default.
• W2895961551 cites W1971450283 @default.
• W2895961551 cites W1987315996 @default.
• W2895961551 cites W1988627259 @default.
• W2895961551 cites W1991762031 @default.
• W2895961551 cites W1996401482 @default.
• W2895961551 cites W1997767315 @default.
• W2895961551 cites W2006229505 @default.
• W2895961551 cites W2008114855 @default.
• W2895961551 cites W2008116454 @default.
• W2895961551 cites W2010188733 @default.
• W2895961551 cites W2015178258 @default.
• W2895961551 cites W2019727922 @default.
• W2895961551 cites W2020295760 @default.
• W2895961551 cites W2021616768 @default.
• W2895961551 cites W2023371207 @default.
• W2895961551 cites W2032275523 @default.
• W2895961551 cites W2043876506 @default.
• W2895961551 cites W2058025252 @default.
• W2895961551 cites W2058132072 @default.
• W2895961551 cites W2067392156 @default.
• W2895961551 cites W2073421494 @default.
• W2895961551 cites W2082588321 @default.
• W2895961551 cites W2087439386 @default.
• W2895961551 cites W2088871098 @default.
• W2895961551 cites W2089380072 @default.
• W2895961551 cites W2091955873 @default.
• W2895961551 cites W2094601234 @default.
• W2895961551 cites W2095681865 @default.
• W2895961551 cites W2100007615 @default.
• W2895961551 cites W2101088288 @default.
• W2895961551 cites W2103273535 @default.
• W2895961551 cites W2103409944 @default.
• W2895961551 cites W2107575131 @default.
• W2895961551 cites W2112604043 @default.
• W2895961551 cites W2116967879 @default.
• W2895961551 cites W2137848437 @default.
• W2895961551 cites W2138313400 @default.
• W2895961551 cites W2143370070 @default.
• W2895961551 cites W2147329907 @default.
• W2895961551 cites W2160392363 @default.
• W2895961551 cites W2165604195 @default.
• W2895961551 cites W2166869464 @default.
• W2895961551 cites W2168145950 @default.
• W2895961551 cites W2182637946 @default.
• W2895961551 cites W2270473500 @default.
• W2895961551 cites W2273951850 @default.
• W2895961551 cites W2322068952 @default.
• W2895961551 cites W2416349187 @default.
• W2895961551 cites W2418829285 @default.
• W2895961551 cites W2607635479 @default.
• W2895961551 cites W2610082402 @default.
• W2895961551 cites W2709184544 @default.
• W2895961551 cites W2739789506 @default.
• W2895961551 cites W2773039272 @default.
• W2895961551 cites W2773910263 @default.
• W2895961551 cites W9355387 @default.
• W2895961551 doi "https://doi.org/10.1038/s41377-018-0080-3" @default.
• W2895961551 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6199289" @default.
• W2895961551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30374401" @default.
• W2895961551 hasPublicationYear "2018" @default.
• W2895961551 type Work @default.
• W2895961551 sameAs 2895961551 @default.
• W2895961551 citedByCount "31" @default.
• W2895961551 countsByYear W28959615512019 @default.
• W2895961551 countsByYear W28959615512020 @default.
• W2895961551 countsByYear W28959615512021 @default.
• W2895961551 countsByYear W28959615512022 @default.
• W2895961551 countsByYear W28959615512023 @default.
• W2895961551 crossrefType "journal-article" @default.
• W2895961551 hasAuthorship W2895961551A5007241569 @default.
• W2895961551 hasAuthorship W2895961551A5041892010 @default.
• W2895961551 hasAuthorship W2895961551A5055086920 @default.
• W2895961551 hasAuthorship W2895961551A5061950718 @default.
• W2895961551 hasAuthorship W2895961551A5067297209 @default.
• W2895961551 hasAuthorship W2895961551A5070548943 @default.
• W2895961551 hasAuthorship W2895961551A5071837046 @default.
• W2895961551 hasBestOaLocation W28959615511 @default.
• W2895961551 hasConcept C103486182 @default.
• W2895961551 hasConcept C120665830 @default.
• W2895961551 hasConcept C121332964 @default.
• W2895961551 hasConcept C12554922 @default.
• W2895961551 hasConcept C136229726 @default.
• W2895961551 hasConcept C159985019 @default.
• W2895961551 hasConcept C185592680 @default.

• next