Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895962596> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2895962596 endingPage "123" @default.
- W2895962596 startingPage "111" @default.
- W2895962596 abstract "This is a quantitative study of retinal structure, progression rates, and interocular symmetry in retinitis pigmentosa GTPase regulator gene (RPGR)-associated retinopathy using spectral-domain optical coherence tomography (OCT).Prospective, observational cohort study.Thirty-eight subjects at Moorfields Eye Hospital in London were assessed with 2 spectral-domain OCT-derived ellipzoid zone (EZ) metrics with repeatability assessments. EZ width (EZW) measurements were made on transfoveal line scans. En face images of the EZ area (EZA) were generated from high-density macular volume scans and were quantified. Baseline size, progression rate, symmetry, associations with age and genotype, and baseline structure-function correlation were investigated.Baseline EZW and EZA measurements were 1963.6 μm and 3.70 mm2, respectively. The mean EZW progression rate was 233.6 μm per year, and the mean EZA rate was 0.67 mm2 per year. Relative interocular difference as an index of symmetry was 3% for both metrics, indicating good baseline symmetry in general-although significant variation existed across the cohort. Analysis of variance found a significant effect of age but not genotype on EZ dimension and progression rates. Larger EZ dimension and greater progression were seen in younger subjects. A positive correlation between EZ dimension and progression was evident. Overall exponential decline rates of 8.2% with EZW and 15.5% with EZA were obtained. Good functional correlation was found with EZW demonstrating stronger correlation; however, EZA correlation with function was also significant.EZ metrics are sensitive structural biomarkers for measuring residual extent and progression in RPGR-associated retinopathy. Our elucidation of the natural history will provide clinicians and patients with more knowledge about the condition and inform the design and interpretation of interventional trials." @default.
- W2895962596 created "2018-10-26" @default.
- W2895962596 creator A5008271942 @default.
- W2895962596 creator A5014985557 @default.
- W2895962596 creator A5049783486 @default.
- W2895962596 creator A5057645061 @default.
- W2895962596 creator A5072330187 @default.
- W2895962596 creator A5090291315 @default.
- W2895962596 date "2019-02-01" @default.
- W2895962596 modified "2023-10-14" @default.
- W2895962596 title "Natural History Study of Retinal Structure, Progression, and Symmetry Using Ellipzoid Zone Metrics in RPGR-Associated Retinopathy" @default.
- W2895962596 cites W1544063520 @default.
- W2895962596 cites W1565206912 @default.
- W2895962596 cites W1971252547 @default.
- W2895962596 cites W1974006653 @default.
- W2895962596 cites W1985179535 @default.
- W2895962596 cites W2012169167 @default.
- W2895962596 cites W2015153021 @default.
- W2895962596 cites W2018410059 @default.
- W2895962596 cites W2032342270 @default.
- W2895962596 cites W2040796930 @default.
- W2895962596 cites W2059580830 @default.
- W2895962596 cites W2070346824 @default.
- W2895962596 cites W2074854567 @default.
- W2895962596 cites W2076335096 @default.
- W2895962596 cites W2093418698 @default.
- W2895962596 cites W2112460137 @default.
- W2895962596 cites W2127028174 @default.
- W2895962596 cites W2142904179 @default.
- W2895962596 cites W2149458881 @default.
- W2895962596 cites W2161723666 @default.
- W2895962596 cites W2257476437 @default.
- W2895962596 cites W2323875666 @default.
- W2895962596 cites W2595798490 @default.
- W2895962596 cites W2752536686 @default.
- W2895962596 cites W2761426009 @default.
- W2895962596 cites W2800625380 @default.
- W2895962596 doi "https://doi.org/10.1016/j.ajo.2018.10.003" @default.
- W2895962596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6355316" @default.
- W2895962596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30312579" @default.
- W2895962596 hasPublicationYear "2019" @default.
- W2895962596 type Work @default.
- W2895962596 sameAs 2895962596 @default.
- W2895962596 citedByCount "38" @default.
- W2895962596 countsByYear W28959625962019 @default.
- W2895962596 countsByYear W28959625962020 @default.
- W2895962596 countsByYear W28959625962021 @default.
- W2895962596 countsByYear W28959625962022 @default.
- W2895962596 countsByYear W28959625962023 @default.
- W2895962596 crossrefType "journal-article" @default.
- W2895962596 hasAuthorship W2895962596A5008271942 @default.
- W2895962596 hasAuthorship W2895962596A5014985557 @default.
- W2895962596 hasAuthorship W2895962596A5049783486 @default.
- W2895962596 hasAuthorship W2895962596A5057645061 @default.
- W2895962596 hasAuthorship W2895962596A5072330187 @default.
- W2895962596 hasAuthorship W2895962596A5090291315 @default.
- W2895962596 hasBestOaLocation W28959625961 @default.
- W2895962596 hasConcept C117220453 @default.
- W2895962596 hasConcept C118487528 @default.
- W2895962596 hasConcept C2524010 @default.
- W2895962596 hasConcept C2780827179 @default.
- W2895962596 hasConcept C2781114197 @default.
- W2895962596 hasConcept C33923547 @default.
- W2895962596 hasConcept C71924100 @default.
- W2895962596 hasConceptScore W2895962596C117220453 @default.
- W2895962596 hasConceptScore W2895962596C118487528 @default.
- W2895962596 hasConceptScore W2895962596C2524010 @default.
- W2895962596 hasConceptScore W2895962596C2780827179 @default.
- W2895962596 hasConceptScore W2895962596C2781114197 @default.
- W2895962596 hasConceptScore W2895962596C33923547 @default.
- W2895962596 hasConceptScore W2895962596C71924100 @default.
- W2895962596 hasFunder F4320306948 @default.
- W2895962596 hasFunder F4320311904 @default.
- W2895962596 hasFunder F4320319987 @default.
- W2895962596 hasLocation W28959625961 @default.
- W2895962596 hasLocation W28959625962 @default.
- W2895962596 hasLocation W28959625963 @default.
- W2895962596 hasLocation W28959625964 @default.
- W2895962596 hasLocation W28959625965 @default.
- W2895962596 hasLocation W28959625966 @default.
- W2895962596 hasOpenAccess W2895962596 @default.
- W2895962596 hasPrimaryLocation W28959625961 @default.
- W2895962596 hasRelatedWork W1843009580 @default.
- W2895962596 hasRelatedWork W2029841208 @default.
- W2895962596 hasRelatedWork W2041896872 @default.
- W2895962596 hasRelatedWork W2078610952 @default.
- W2895962596 hasRelatedWork W2402796057 @default.
- W2895962596 hasRelatedWork W4233329698 @default.
- W2895962596 hasRelatedWork W584015088 @default.
- W2895962596 hasRelatedWork W7340977 @default.
- W2895962596 hasRelatedWork W806426592 @default.
- W2895962596 hasRelatedWork W2040119765 @default.
- W2895962596 hasVolume "198" @default.
- W2895962596 isParatext "false" @default.
- W2895962596 isRetracted "false" @default.
- W2895962596 magId "2895962596" @default.
- W2895962596 workType "article" @default.