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- W2895964723 abstract "MCL-1 inhibition in cancer treatment Weiguo Xiang,1 Chao-Yie Yang,1,2 Longchuan Bai1,2 1Department of Internal Medicine, University of Michigan Medical School, 2Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA Abstract: Myeloid cell leukemia-1 (MCL-1), a member of antiapoptotic BCL-2 family proteins, is a key regulator of mitochondrial homeostasis. Frequent overexpression of MCL-1 in human primary and drug-resistant cancer cells makes it an attractive cancer therapeutic target. Significant progress has been made in the development of small-molecule MCL-1 inhibitors in recent years, and three MCL-1 selective inhibitors have advanced to clinical trials. This review briefly discusses recent advances in the development of small molecules targeting MCL-1 for cancer therapy. Keywords: BCL-2, BAX, BAK, apoptosis, BH3 mimetics" @default.
- W2895964723 created "2018-10-26" @default.
- W2895964723 creator A5012092064 @default.
- W2895964723 creator A5049458323 @default.
- W2895964723 creator A5080779901 @default.
- W2895964723 date "2018-10-01" @default.
- W2895964723 modified "2023-10-11" @default.
- W2895964723 title "MCL-1 inhibition in cancer treatment" @default.
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- W2895964723 doi "https://doi.org/10.2147/ott.s146228" @default.
- W2895964723 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6205821" @default.