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• W2895964891 abstract "The relationship between cognitive impairment and AD neuroimaging biomarkers has been of great interest to gain insights into the mechanisms by which AD-associated neuropathologies and neurodegeneration affect the clinical symptoms in different disease stages. We investigated to what extent brain atrophy and tau pathology, separately and jointly, explained the variance in the level of cognitive impairment within various stages of the AD. We obtained cross-sectional multimodality neuroimaging data(structural-MRI and flortaucipir-PET) from 332 patients ranging from Aβ- cognitively normals (CN;N=136),Aβ+ CN (N=98),Aβ+ MCI (n=67) to Aβ+ AD (n=31) from the ADNI study. Within each group, we used partial least squares regression with the neuroimaging measures(i.e, cortical thickness from structural-MRI and tau SUVR from flortaucipir-PET) from each and every imaging voxel as independent variables to assess the patterns of neuroimaging-cognition associations for measures of compositive memory function (ADNI-MEM), compositive executive function (ADNI-EF), ADAS-Cog (TOTAL13 and TOTSCORE), and MMSE (MMSCORE). We assessed joint-contribution of multimodality data by convexly combining neuroimaging measures with a relative weighting coefficient of 0<x<1. Plots in the attached figure show variance explained by neuroimaging data as a function of modality weighting (i.e.,x=0 for pure cortical thickness correlates of cognitive impairment and x=1 for pure tau correlates of cognitive impairment) along with whole brain signatures of cortical thickness and tau for composite memory function. In Aβ+ CN (i.e., asymptomatic) and Aβ+ AD (i.e.,clinical disease) stages, cortical thickness was the dominating imaging biomarker in explaining within cohort variance in memory,executive function, and global cognitive functioning. In Aβ+ MCI (i.e., prodromal) disease stage, cortical thickness, and tau imaging signatures both had added-value in explaining within cohort variance in memory, executive function, and global cognitive functioning." @default.
• W2895964891 created "2018-10-26" @default.
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• W2895964891 date "2018-07-01" @default.
• W2895964891 modified "2023-09-26" @default.
• W2895964891 title "P4‐302: DISEASE‐STAGE SPECIFIC RELATIONSHIP BETWEEN COGNITION, ATROPHY, AND TAU BURDEN IN ALZHEIMER'S DISEASE" @default.
• W2895964891 doi "https://doi.org/10.1016/j.jalz.2018.07.125" @default.
• W2895964891 hasPublicationYear "2018" @default.
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