FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895965626> ?p ?o ?g. }

• W2895965626 abstract "ABSTRACT: Lung cancer has a 5-year survival rate of 17% with current standard-of-care radiation and chemotherapies (1,2,4,8,9). Immune escape contributes to poor tumor clearance driving the development of therapies that promote anti-tumor immune responses (29-33). The cytotoxic T-lymphocyte response distinguishes cancerous cells by the presentation of mutated endogenous antigens on MHC-1 molecules (26,29-33). Radiation therapy has been shown to increase MHC-1 antigen presentation (22-23,30). It has been proposed that DNA-damage response signaling inhibits translation during radiation induced cell recovery resulting in a post-repair spike in translation and MHC-1 presentation (22-23,30). We hypothesize that ATM and ATR inhibition will disrupt the negative regulation of translation post-radiation to impact the rate of MHC-1 presentation. Increasing antigen presentation before cell recovery from radiation damage may increase the magnitude of mutant antigens to stimulate anti-tumor CD8+ T-cell activation. This investigation attempted to monitor the impact of DNA-damage response inhibition on translation and subsequent MHC-1 presentation post-radiation at two levels. First, fluctuations in the intracellular peptide pool available for MHC-1 antigen loading was measured via the activity of Transporter associated with Antigen Processing (TAP) responsible for shuttling cytosolic peptides into the ER for MHC-1 antigen loading (20-2226). Fluorescence Recovery After Photobleaching (FRAP) of TAP1-mNeonGreen was used to calculate the lateral diffusion of TAP within the ER membrane as diffusion is inversely correlated to TAP activity. Second, MHC-1 cell surface presentation was measured via flow cytometry." @default.
• W2895965626 created "2018-10-26" @default.
• W2895965626 creator A5008779720 @default.
• W2895965626 date "2018-09-11" @default.
• W2895965626 modified "2023-09-27" @default.
• W2895965626 title "PROGRESS TOWARDS INVESTIGATION OF THE IMPACT OF TARGETED INHIBITION OF POTENTIAL DNA-DAMAGE RESPONSE REGULATION OF TRANSLATION IN IRRADIATED NON-SMALL CELL LUNG CANCER CELL LINES" @default.
• W2895965626 cites W1597994956 @default.
• W2895965626 cites W1841003668 @default.
• W2895965626 cites W1998548282 @default.
• W2895965626 cites W2002226709 @default.
• W2895965626 cites W2006721912 @default.
• W2895965626 cites W2012122483 @default.
• W2895965626 cites W2024231564 @default.
• W2895965626 cites W2043972688 @default.
• W2895965626 cites W2071457560 @default.
• W2895965626 cites W2073621589 @default.
• W2895965626 cites W2081886885 @default.
• W2895965626 cites W2092997044 @default.
• W2895965626 cites W2096064375 @default.
• W2895965626 cites W2105719362 @default.
• W2895965626 cites W2106905343 @default.
• W2895965626 cites W2111772438 @default.
• W2895965626 cites W2112220442 @default.
• W2895965626 cites W2113164415 @default.
• W2895965626 cites W2117692326 @default.
• W2895965626 cites W2124382899 @default.
• W2895965626 cites W2132089894 @default.
• W2895965626 cites W2173456459 @default.
• W2895965626 cites W2180481128 @default.
• W2895965626 cites W2201979800 @default.
• W2895965626 cites W2414367793 @default.
• W2895965626 cites W2518572164 @default.
• W2895965626 cites W2602997708 @default.
• W2895965626 hasPublicationYear "2018" @default.
• W2895965626 type Work @default.
• W2895965626 sameAs 2895965626 @default.
• W2895965626 citedByCount "0" @default.
• W2895965626 crossrefType "journal-article" @default.
• W2895965626 hasAuthorship W2895965626A5008779720 @default.
• W2895965626 hasConcept C108249834 @default.
• W2895965626 hasConcept C147483822 @default.
• W2895965626 hasConcept C154317977 @default.
• W2895965626 hasConcept C167672396 @default.
• W2895965626 hasConcept C170627219 @default.
• W2895965626 hasConcept C202751555 @default.
• W2895965626 hasConcept C203014093 @default.
• W2895965626 hasConcept C207936829 @default.
• W2895965626 hasConcept C22845430 @default.
• W2895965626 hasConcept C26659971 @default.
• W2895965626 hasConcept C2776090121 @default.
• W2895965626 hasConcept C41625074 @default.
• W2895965626 hasConcept C502942594 @default.
• W2895965626 hasConcept C55493867 @default.
• W2895965626 hasConcept C83464605 @default.
• W2895965626 hasConcept C86803240 @default.
• W2895965626 hasConcept C8891405 @default.
• W2895965626 hasConcept C95444343 @default.
• W2895965626 hasConceptScore W2895965626C108249834 @default.
• W2895965626 hasConceptScore W2895965626C147483822 @default.
• W2895965626 hasConceptScore W2895965626C154317977 @default.
• W2895965626 hasConceptScore W2895965626C167672396 @default.
• W2895965626 hasConceptScore W2895965626C170627219 @default.
• W2895965626 hasConceptScore W2895965626C202751555 @default.
• W2895965626 hasConceptScore W2895965626C203014093 @default.
• W2895965626 hasConceptScore W2895965626C207936829 @default.
• W2895965626 hasConceptScore W2895965626C22845430 @default.
• W2895965626 hasConceptScore W2895965626C26659971 @default.
• W2895965626 hasConceptScore W2895965626C2776090121 @default.
• W2895965626 hasConceptScore W2895965626C41625074 @default.
• W2895965626 hasConceptScore W2895965626C502942594 @default.
• W2895965626 hasConceptScore W2895965626C55493867 @default.
• W2895965626 hasConceptScore W2895965626C83464605 @default.
• W2895965626 hasConceptScore W2895965626C86803240 @default.
• W2895965626 hasConceptScore W2895965626C8891405 @default.
• W2895965626 hasConceptScore W2895965626C95444343 @default.
• W2895965626 hasLocation W28959656261 @default.
• W2895965626 hasOpenAccess W2895965626 @default.
• W2895965626 hasPrimaryLocation W28959656261 @default.
• W2895965626 hasRelatedWork W1531610451 @default.
• W2895965626 hasRelatedWork W1853088825 @default.
• W2895965626 hasRelatedWork W1970239975 @default.
• W2895965626 hasRelatedWork W1984910163 @default.
• W2895965626 hasRelatedWork W1993993797 @default.
• W2895965626 hasRelatedWork W1999843922 @default.
• W2895965626 hasRelatedWork W2024434117 @default.
• W2895965626 hasRelatedWork W2034608303 @default.
• W2895965626 hasRelatedWork W2046107482 @default.
• W2895965626 hasRelatedWork W2063821602 @default.
• W2895965626 hasRelatedWork W2093172507 @default.
• W2895965626 hasRelatedWork W2560920541 @default.
• W2895965626 hasRelatedWork W2585539786 @default.
• W2895965626 hasRelatedWork W2783231332 @default.
• W2895965626 hasRelatedWork W2788672255 @default.
• W2895965626 hasRelatedWork W2896607128 @default.
• W2895965626 hasRelatedWork W2913130449 @default.
• W2895965626 hasRelatedWork W2949952797 @default.
• W2895965626 hasRelatedWork W2977290732 @default.
• W2895965626 hasRelatedWork W3123588281 @default.
• W2895965626 isParatext "false" @default.
• W2895965626 isRetracted "false" @default.

• next