FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895965669> ?p ?o ?g. }

• W2895965669 abstract "Background: Huang-Lian-Jie-Du-Decoction (HLJDD), a prescription of traditional Chinese medicine, has been clinically used to treat diabetes for thousands of years and its mechanism was reported to be related to gut microbiota. However, no study has explored the effect of HLJDD on the gut microbiota in type 2 diabetes mellitus (T2DM) yet. Therefore, in this study, we investigated the modulation of gut microbiota induced by HLJDD treatment in T2DM in order to unveil the underlying mechanism. Methods: A combination of high-fat diet (HFD) and streptozotocin (STZ) was used to induce T2DM in rats. Bacterial communities in the fecal samples from the control group, the T2DM model group, and the HLJDD-treated T2DM group were analyzed by 16S gene sequencing, followed with a subset sample analyzed by shotgun sequencing. Results: The HLJDD treatment significantly ameliorated hyperglycemia and inflammation in T2DM rats. Additionally, our results indicated that HLJDD treatment could not only restore the gut dysbiosis in T2DM rats, which was proved by an increasing amount of short chain fatty acids (SCFAs)-producing and anti-inflammatory bacteria such as Parabacteroides, Blautia, and Akkermansia as well as a decreasing amount of conditioned pathogenic bacteria (e.g., Aerococcus, Staphylococcus, and Corynebacterium), but also modulate the dysregulated function of gut microbiome in T2DM rats, including an up-regulation in bile acid biosynthesis as well as a reduction in glycolysis/gluconeogenesis and nucleotide metabolism. Conclusion: HLJDD treatment could ameliorate hyperglycemia and restore the dysregulated microbiota structure and function to a normal condition mainly by increasing SCFAs-producing bacteria and reducing conditioned pathogenic bacteria in T2DM rats, which provides insights into the mechanism of HLJDD treatment for T2DM from the view of gut microbiota." @default.
• W2895965669 created "2018-10-26" @default.
• W2895965669 creator A5003151279 @default.
• W2895965669 creator A5005834020 @default.
• W2895965669 creator A5008841900 @default.
• W2895965669 creator A5014982480 @default.
• W2895965669 creator A5025539966 @default.
• W2895965669 creator A5042062615 @default.
• W2895965669 creator A5046876523 @default.
• W2895965669 creator A5064837903 @default.
• W2895965669 creator A5079900226 @default.
• W2895965669 creator A5087158302 @default.
• W2895965669 date "2018-10-08" @default.
• W2895965669 modified "2023-10-15" @default.
• W2895965669 title "Huang-Lian-Jie-Du-Decoction Ameliorates Hyperglycemia and Insulin Resistant in Association With Gut Microbiota Modulation" @default.
• W2895965669 cites W1589649796 @default.
• W2895965669 cites W1793035576 @default.
• W2895965669 cites W1842274844 @default.
• W2895965669 cites W1856033750 @default.
• W2895965669 cites W1897910051 @default.
• W2895965669 cites W1913497650 @default.
• W2895965669 cites W1943116081 @default.
• W2895965669 cites W1964027278 @default.
• W2895965669 cites W1980894737 @default.
• W2895965669 cites W1988925586 @default.
• W2895965669 cites W2005847833 @default.
• W2895965669 cites W2009039250 @default.
• W2895965669 cites W2020916024 @default.
• W2895965669 cites W2036009897 @default.
• W2895965669 cites W2036404181 @default.
• W2895965669 cites W2046739987 @default.
• W2895965669 cites W2060716312 @default.
• W2895965669 cites W2070461157 @default.
• W2895965669 cites W2071841602 @default.
• W2895965669 cites W2072970694 @default.
• W2895965669 cites W2081943197 @default.
• W2895965669 cites W2086623759 @default.
• W2895965669 cites W2088833470 @default.
• W2895965669 cites W2094566567 @default.
• W2895965669 cites W2099418238 @default.
• W2895965669 cites W2103441770 @default.
• W2895965669 cites W2103502196 @default.
• W2895965669 cites W2108865848 @default.
• W2895965669 cites W2110300022 @default.
• W2895965669 cites W2116103269 @default.
• W2895965669 cites W2121797177 @default.
• W2895965669 cites W2123060905 @default.
• W2895965669 cites W2129933858 @default.
• W2895965669 cites W2133856765 @default.
• W2895965669 cites W2134140786 @default.
• W2895965669 cites W2136879569 @default.
• W2895965669 cites W2141653683 @default.
• W2895965669 cites W2143196592 @default.
• W2895965669 cites W2147790901 @default.
• W2895965669 cites W2149515881 @default.
• W2895965669 cites W2153109441 @default.
• W2895965669 cites W2157107905 @default.
• W2895965669 cites W2160937374 @default.
• W2895965669 cites W2161449122 @default.
• W2895965669 cites W2166562121 @default.
• W2895965669 cites W2206113668 @default.
• W2895965669 cites W2206854629 @default.
• W2895965669 cites W2218580430 @default.
• W2895965669 cites W2325821426 @default.
• W2895965669 cites W2328023807 @default.
• W2895965669 cites W2396003270 @default.
• W2895965669 cites W2460803411 @default.
• W2895965669 cites W2478178708 @default.
• W2895965669 cites W2528199903 @default.
• W2895965669 cites W2536700216 @default.
• W2895965669 cites W2569924413 @default.
• W2895965669 cites W2587602598 @default.
• W2895965669 cites W2606953164 @default.
• W2895965669 cites W2746646675 @default.
• W2895965669 cites W2753532776 @default.
• W2895965669 cites W2759271367 @default.
• W2895965669 cites W2763226628 @default.
• W2895965669 cites W2806350604 @default.
• W2895965669 cites W4240660736 @default.
• W2895965669 cites W4247053599 @default.
• W2895965669 cites W2001030826 @default.
• W2895965669 cites W2048774019 @default.
• W2895965669 doi "https://doi.org/10.3389/fmicb.2018.02380" @default.
• W2895965669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6186778" @default.
• W2895965669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30349514" @default.
• W2895965669 hasPublicationYear "2018" @default.
• W2895965669 type Work @default.
• W2895965669 sameAs 2895965669 @default.
• W2895965669 citedByCount "83" @default.
• W2895965669 countsByYear W28959656692019 @default.
• W2895965669 countsByYear W28959656692020 @default.
• W2895965669 countsByYear W28959656692021 @default.
• W2895965669 countsByYear W28959656692022 @default.
• W2895965669 countsByYear W28959656692023 @default.
• W2895965669 crossrefType "journal-article" @default.
• W2895965669 hasAuthorship W2895965669A5003151279 @default.
• W2895965669 hasAuthorship W2895965669A5005834020 @default.
• W2895965669 hasAuthorship W2895965669A5008841900 @default.
• W2895965669 hasAuthorship W2895965669A5014982480 @default.
• W2895965669 hasAuthorship W2895965669A5025539966 @default.

• next