FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895967710> ?p ?o ?g. }

• W2895967710 endingPage "2715" @default.
• W2895967710 startingPage "2703" @default.
• W2895967710 abstract "Computed tomography and finite element modeling were used to assess bone structure at the knee as a function of time after spinal cord injury. Analyzed regions experienced degradation in stiffness, mineral density, and content. Changes were well described as an exponential decay over time, reaching a steady state 3.5 years after injury. Spinal cord injury (SCI) is associated with bone fragility and an increased risk of fracture around the knee. The purpose of this study was to investigate bone stiffness and mineral content at the distal femur and proximal tibia, using finite element (FE) and computed tomography (CT) measures. A cross-sectional design was used to compare differences between non-ambulatory individuals with SCI as a function of time after injury (0–50 years). CT scans of the knee were obtained from 101 individuals who experienced an SCI 30 days to 50 years prior to participation. Subject-specific FE models were used to estimate stiffness under axial compression and torsional loading, and CT data was analyzed to assess volumetric bone mineral density (vBMD) and bone mineral content (BMC) for integral, cortical, and trabecular compartments of the epiphyseal, metaphyseal, and diaphyseal regions of the distal femur and proximal tibia. Bone degradation was well described as an exponential decay over time (R2 = 0.33–0.83), reaching steady-state levels within 3.6 years of SCI. Individuals at a steady state had 40 to 85% lower FE-derived bone stiffness and robust decreases in CT mineral measures, compared to individuals who were recently injured (t ≤ 47 days). Temporal and spatial patterns of bone loss were similar between the distal femur and proximal tibia. After SCI, individuals experienced rapid and profound reductions in bone stiffness and bone mineral at the knee. FE models predicted similar reductions to axial and torsional stiffness, suggesting that both failure modes may be clinically relevant. Importantly, CT-derived measures of bone mineral alone underpredicted the impacts of SCI, compared to FE-derived measures of stiffness. ClinicalTrials.gov (NCT01225055, NCT02325414)" @default.
• W2895967710 created "2018-10-26" @default.
• W2895967710 creator A5003932519 @default.
• W2895967710 creator A5039979518 @default.
• W2895967710 creator A5064599465 @default.
• W2895967710 creator A5071424942 @default.
• W2895967710 creator A5082487099 @default.
• W2895967710 date "2018-10-17" @default.
• W2895967710 modified "2023-10-15" @default.
• W2895967710 title "Bone fragility after spinal cord injury: reductions in stiffness and bone mineral at the distal femur and proximal tibia as a function of time" @default.
• W2895967710 cites W1467100248 @default.
• W2895967710 cites W1920581718 @default.
• W2895967710 cites W1964678256 @default.
• W2895967710 cites W1968092726 @default.
• W2895967710 cites W1969762569 @default.
• W2895967710 cites W1987629029 @default.
• W2895967710 cites W1993110673 @default.
• W2895967710 cites W2001804742 @default.
• W2895967710 cites W2002020139 @default.
• W2895967710 cites W2008275133 @default.
• W2895967710 cites W2025123453 @default.
• W2895967710 cites W2034975399 @default.
• W2895967710 cites W2039103450 @default.
• W2895967710 cites W2046268652 @default.
• W2895967710 cites W2046354206 @default.
• W2895967710 cites W2058053680 @default.
• W2895967710 cites W2069290828 @default.
• W2895967710 cites W2097773954 @default.
• W2895967710 cites W2100936182 @default.
• W2895967710 cites W2108918650 @default.
• W2895967710 cites W2111466366 @default.
• W2895967710 cites W2119662096 @default.
• W2895967710 cites W2140549584 @default.
• W2895967710 cites W2145069783 @default.
• W2895967710 cites W2148458605 @default.
• W2895967710 cites W2148991704 @default.
• W2895967710 cites W2150601537 @default.
• W2895967710 cites W2162642289 @default.
• W2895967710 cites W2170507497 @default.
• W2895967710 cites W2172043022 @default.
• W2895967710 cites W2765296419 @default.
• W2895967710 cites W2782633655 @default.
• W2895967710 cites W2807916618 @default.
• W2895967710 cites W4211003818 @default.
• W2895967710 doi "https://doi.org/10.1007/s00198-018-4733-0" @default.
• W2895967710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6369927" @default.
• W2895967710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30334093" @default.
• W2895967710 hasPublicationYear "2018" @default.
• W2895967710 type Work @default.
• W2895967710 sameAs 2895967710 @default.
• W2895967710 citedByCount "26" @default.
• W2895967710 countsByYear W28959677102019 @default.
• W2895967710 countsByYear W28959677102020 @default.
• W2895967710 countsByYear W28959677102021 @default.
• W2895967710 countsByYear W28959677102022 @default.
• W2895967710 countsByYear W28959677102023 @default.
• W2895967710 crossrefType "journal-article" @default.
• W2895967710 hasAuthorship W2895967710A5003932519 @default.
• W2895967710 hasAuthorship W2895967710A5039979518 @default.
• W2895967710 hasAuthorship W2895967710A5064599465 @default.
• W2895967710 hasAuthorship W2895967710A5071424942 @default.
• W2895967710 hasAuthorship W2895967710A5082487099 @default.
• W2895967710 hasBestOaLocation W28959677102 @default.
• W2895967710 hasConcept C105702510 @default.
• W2895967710 hasConcept C118552586 @default.
• W2895967710 hasConcept C126322002 @default.
• W2895967710 hasConcept C141071460 @default.
• W2895967710 hasConcept C195121873 @default.
• W2895967710 hasConcept C2776541429 @default.
• W2895967710 hasConcept C2776886416 @default.
• W2895967710 hasConcept C2777236700 @default.
• W2895967710 hasConcept C2777425516 @default.
• W2895967710 hasConcept C2778334475 @default.
• W2895967710 hasConcept C2780554211 @default.
• W2895967710 hasConcept C2780775167 @default.
• W2895967710 hasConcept C29694066 @default.
• W2895967710 hasConcept C68312169 @default.
• W2895967710 hasConcept C71924100 @default.
• W2895967710 hasConceptScore W2895967710C105702510 @default.
• W2895967710 hasConceptScore W2895967710C118552586 @default.
• W2895967710 hasConceptScore W2895967710C126322002 @default.
• W2895967710 hasConceptScore W2895967710C141071460 @default.
• W2895967710 hasConceptScore W2895967710C195121873 @default.
• W2895967710 hasConceptScore W2895967710C2776541429 @default.
• W2895967710 hasConceptScore W2895967710C2776886416 @default.
• W2895967710 hasConceptScore W2895967710C2777236700 @default.
• W2895967710 hasConceptScore W2895967710C2777425516 @default.
• W2895967710 hasConceptScore W2895967710C2778334475 @default.
• W2895967710 hasConceptScore W2895967710C2780554211 @default.
• W2895967710 hasConceptScore W2895967710C2780775167 @default.
• W2895967710 hasConceptScore W2895967710C29694066 @default.
• W2895967710 hasConceptScore W2895967710C68312169 @default.
• W2895967710 hasConceptScore W2895967710C71924100 @default.
• W2895967710 hasFunder F4320306078 @default.
• W2895967710 hasFunder F4320306080 @default.
• W2895967710 hasIssue "12" @default.
• W2895967710 hasLocation W28959677101 @default.
• W2895967710 hasLocation W28959677102 @default.

• next