FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895969574> ?p ?o ?g. }

• W2895969574 endingPage "700" @default.
• W2895969574 startingPage "692" @default.
• W2895969574 abstract "Transient receptor potential ankyrin 1 (TRPA1) and substance P (SP), both expression in sensory neurons, have important roles in stress-induced duodenal lesions. The possible contribution of TRPA1 and SP to stress-induced duodenal lesions was explored by using the water immersion restraint stress (WIRS) rat model.Western blotting, Real-time polymerase chain reaction (RT-PCR), and immunohistochemistry assay were used to evaluate the changes of TRPA1and SP expression in the dorsal root ganglia (DRG, T8-11), the corresponding segment of the spinal cord (T8-11), and the duodenum in a duodenal lesions rat model. The SP concentrations of duodenal mucosa were investigated using an enzyme-linked immunosorbent assay (ELISA). Duodenal lesions were assessed according to histopathological changes. TRPA1 specific antagonist HC-030031 was intrathecally or intraperitoneally performed to suppress the expression of both TRPA1 and SP for evaluating the roles of TRPA1 and SP in duodenal lesions.In contrast to the control group, TRPA1 and substance P in the DRG (T8-11) and duodenum were up-regulated, and concentrations of SP in the duodenal mucosa were increased after WIRS (p<0.05), which are closely associated with duodenal lesions. SP concentrations in the duodenal mucosa were decreased and duodenal lesions were alleviated by pretreatment with TRPA1 antagonist HC-030031. We identified a protective role for HC-030031 in WIRS-induced duodenal lesions. Furthermore, we demonstrated that WIRS increased the concentrations of SP in the duodenal mucosa in a TRPA1-dependent manner. However, WIRS caused no significant changes of TRPA1 and SP in the spinal cord (T8-11) compared with the control group (p>0.05).Our study indicates that TRPA1 antagonist HC-030031 alleviates duodenal lesions. TRPA1 is activated and sensitized, therefore concomitant neuropeptide SP is released, which exerts a critical role in inducing and maintaining duodenal lesions following WIRS in rats. This provides evidence that neuroimmune interactions may control duodenal injury. TRPA1 may be a potential drug target to inhibit the development of duodenal lesions by stress-induced in patients." @default.
• W2895969574 created "2018-10-26" @default.
• W2895969574 creator A5009267475 @default.
• W2895969574 creator A5021662366 @default.
• W2895969574 creator A5057500762 @default.
• W2895969574 creator A5075211533 @default.
• W2895969574 creator A5081070318 @default.
• W2895969574 creator A5083440332 @default.
• W2895969574 creator A5087925438 @default.
• W2895969574 date "2018-10-22" @default.
• W2895969574 modified "2023-09-27" @default.
• W2895969574 title "TRPA1 and substance P mediate stress induced duodenal lesions in water immersion restraint stress rat model" @default.
• W2895969574 cites W1543856987 @default.
• W2895969574 cites W1584906997 @default.
• W2895969574 cites W1883044208 @default.
• W2895969574 cites W1949759409 @default.
• W2895969574 cites W1974062591 @default.
• W2895969574 cites W1984260099 @default.
• W2895969574 cites W1985464800 @default.
• W2895969574 cites W1990408451 @default.
• W2895969574 cites W1995594267 @default.
• W2895969574 cites W1996891599 @default.
• W2895969574 cites W2004418784 @default.
• W2895969574 cites W2007254610 @default.
• W2895969574 cites W2010791139 @default.
• W2895969574 cites W2016482156 @default.
• W2895969574 cites W2035495492 @default.
• W2895969574 cites W2048862160 @default.
• W2895969574 cites W2059699981 @default.
• W2895969574 cites W2061195612 @default.
• W2895969574 cites W2062993520 @default.
• W2895969574 cites W2070162219 @default.
• W2895969574 cites W2077222278 @default.
• W2895969574 cites W2081575083 @default.
• W2895969574 cites W2084988952 @default.
• W2895969574 cites W2092571790 @default.
• W2895969574 cites W2118749186 @default.
• W2895969574 cites W2120229762 @default.
• W2895969574 cites W2122526508 @default.
• W2895969574 cites W2150934660 @default.
• W2895969574 cites W2156291426 @default.
• W2895969574 cites W2156733405 @default.
• W2895969574 cites W2158910629 @default.
• W2895969574 cites W2160983133 @default.
• W2895969574 cites W2161605623 @default.
• W2895969574 cites W2340981781 @default.
• W2895969574 cites W2461210327 @default.
• W2895969574 cites W2462143301 @default.
• W2895969574 cites W2583517217 @default.
• W2895969574 cites W2789809278 @default.
• W2895969574 cites W4243927500 @default.
• W2895969574 cites W4247936073 @default.
• W2895969574 cites W4298473436 @default.
• W2895969574 doi "https://doi.org/10.5152/tjg.2018.17817" @default.
• W2895969574 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6284685" @default.
• W2895969574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30381276" @default.
• W2895969574 hasPublicationYear "2018" @default.
• W2895969574 type Work @default.
• W2895969574 sameAs 2895969574 @default.
• W2895969574 citedByCount "3" @default.
• W2895969574 countsByYear W28959695742020 @default.
• W2895969574 countsByYear W28959695742021 @default.
• W2895969574 countsByYear W28959695742023 @default.
• W2895969574 crossrefType "journal-article" @default.
• W2895969574 hasAuthorship W2895969574A5009267475 @default.
• W2895969574 hasAuthorship W2895969574A5021662366 @default.
• W2895969574 hasAuthorship W2895969574A5057500762 @default.
• W2895969574 hasAuthorship W2895969574A5075211533 @default.
• W2895969574 hasAuthorship W2895969574A5081070318 @default.
• W2895969574 hasAuthorship W2895969574A5083440332 @default.
• W2895969574 hasAuthorship W2895969574A5087925438 @default.
• W2895969574 hasBestOaLocation W28959695742 @default.
• W2895969574 hasConcept C104317684 @default.
• W2895969574 hasConcept C118303440 @default.
• W2895969574 hasConcept C126322002 @default.
• W2895969574 hasConcept C127561419 @default.
• W2895969574 hasConcept C134018914 @default.
• W2895969574 hasConcept C142724271 @default.
• W2895969574 hasConcept C170493617 @default.
• W2895969574 hasConcept C185592680 @default.
• W2895969574 hasConcept C204232928 @default.
• W2895969574 hasConcept C2776415932 @default.
• W2895969574 hasConcept C2776533618 @default.
• W2895969574 hasConcept C2776809568 @default.
• W2895969574 hasConcept C2776885963 @default.
• W2895969574 hasConcept C55493867 @default.
• W2895969574 hasConcept C71924100 @default.
• W2895969574 hasConcept C90924648 @default.
• W2895969574 hasConceptScore W2895969574C104317684 @default.
• W2895969574 hasConceptScore W2895969574C118303440 @default.
• W2895969574 hasConceptScore W2895969574C126322002 @default.
• W2895969574 hasConceptScore W2895969574C127561419 @default.
• W2895969574 hasConceptScore W2895969574C134018914 @default.
• W2895969574 hasConceptScore W2895969574C142724271 @default.
• W2895969574 hasConceptScore W2895969574C170493617 @default.
• W2895969574 hasConceptScore W2895969574C185592680 @default.
• W2895969574 hasConceptScore W2895969574C204232928 @default.
• W2895969574 hasConceptScore W2895969574C2776415932 @default.

• next