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- W2895971387 abstract "Neuroinflammation is one of the most important processes involved in the pathogenesis of Parkinson's disease (PD). The current concept of neuroinflammation comprises an inflammation process, which occurs in the central nervous system due to molecules released from brain-resident and/or blood-derived immune cells. Furthermore, the evidence of the contribution of systemic delivered molecules to the disease pathogenesis, such as the gut microbiota composition, has been increasing during the last years. Under physiological conditions, microglia and astrocytes support the well-being and well-function of the brain through diverse functions, including neurotrophic factor secretion in both intact and injured brain. On the other hand, genes that cause PD are expressed in astrocytes and microglia, shifting their neuroprotective role to a pathogenic one, contributing to disease onset and progression. In addition, growth factors are a subset of molecules that promote cellular survival, differentiation and maturation, which are critical signaling factors promoting the communication between cells, including neurons and blood-derived immune cells. We summarize the potential targeting of astrocytes and microglia and the systemic contribution of the gut microbiota in neuroinflammation process archived in PD." @default.
- W2895971387 created "2018-10-26" @default.
- W2895971387 creator A5021927467 @default.
- W2895971387 creator A5023567204 @default.
- W2895971387 creator A5031682950 @default.
- W2895971387 creator A5045258642 @default.
- W2895971387 date "2018-10-15" @default.
- W2895971387 modified "2023-10-16" @default.
- W2895971387 title "Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease" @default.
- W2895971387 cites W1493890929 @default.
- W2895971387 cites W150707268 @default.
- W2895971387 cites W1515023627 @default.
- W2895971387 cites W1533317424 @default.
- W2895971387 cites W1540142856 @default.
- W2895971387 cites W1564387586 @default.
- W2895971387 cites W1622777525 @default.
- W2895971387 cites W1626583747 @default.
- W2895971387 cites W1629697287 @default.
- W2895971387 cites W1639349134 @default.
- W2895971387 cites W175813982 @default.
- W2895971387 cites W1807343300 @default.
- W2895971387 cites W1846664948 @default.
- W2895971387 cites W1872256228 @default.
- W2895971387 cites W1877004954 @default.
- W2895971387 cites W1903888485 @default.
- W2895971387 cites W1918237073 @default.
- W2895971387 cites W1920510593 @default.
- W2895971387 cites W1929553926 @default.
- W2895971387 cites W1963585873 @default.
- W2895971387 cites W1964244234 @default.
- W2895971387 cites W1965942744 @default.
- W2895971387 cites W1966805482 @default.
- W2895971387 cites W1967640115 @default.
- W2895971387 cites W1967659552 @default.
- W2895971387 cites W1969305530 @default.
- W2895971387 cites W1970334555 @default.
- W2895971387 cites W1971208141 @default.
- W2895971387 cites W1972240224 @default.
- W2895971387 cites W1972939055 @default.
- W2895971387 cites W1972998250 @default.
- W2895971387 cites W1976769213 @default.
- W2895971387 cites W1979237351 @default.
- W2895971387 cites W1979252384 @default.
- W2895971387 cites W1980020952 @default.
- W2895971387 cites W1981500982 @default.
- W2895971387 cites W1984050978 @default.
- W2895971387 cites W1986294212 @default.
- W2895971387 cites W1986716278 @default.
- W2895971387 cites W1988452935 @default.
- W2895971387 cites W1991417429 @default.
- W2895971387 cites W1993790483 @default.
- W2895971387 cites W1995281235 @default.
- W2895971387 cites W1997355141 @default.
- W2895971387 cites W1998880668 @default.
- W2895971387 cites W1999385317 @default.
- W2895971387 cites W2000345747 @default.
- W2895971387 cites W2003728047 @default.
- W2895971387 cites W2004349171 @default.
- W2895971387 cites W2004746939 @default.
- W2895971387 cites W2008147706 @default.
- W2895971387 cites W2012490955 @default.
- W2895971387 cites W2015167814 @default.
- W2895971387 cites W2019863741 @default.
- W2895971387 cites W2020279139 @default.
- W2895971387 cites W2020495469 @default.
- W2895971387 cites W2023592848 @default.
- W2895971387 cites W2028827022 @default.
- W2895971387 cites W2030500910 @default.
- W2895971387 cites W2031499319 @default.
- W2895971387 cites W2032886713 @default.
- W2895971387 cites W2033386838 @default.
- W2895971387 cites W2033827101 @default.
- W2895971387 cites W2033966441 @default.
- W2895971387 cites W2034254855 @default.
- W2895971387 cites W2039758887 @default.
- W2895971387 cites W2040250147 @default.
- W2895971387 cites W2040934666 @default.
- W2895971387 cites W2041135804 @default.
- W2895971387 cites W2044701263 @default.
- W2895971387 cites W2044908785 @default.
- W2895971387 cites W2047798386 @default.
- W2895971387 cites W2053385938 @default.
- W2895971387 cites W2054810445 @default.
- W2895971387 cites W2055750901 @default.
- W2895971387 cites W2057100984 @default.
- W2895971387 cites W2058914023 @default.
- W2895971387 cites W2058931009 @default.
- W2895971387 cites W2059971906 @default.
- W2895971387 cites W2059996790 @default.
- W2895971387 cites W2061471792 @default.
- W2895971387 cites W2063893203 @default.
- W2895971387 cites W2064344027 @default.
- W2895971387 cites W2065336907 @default.
- W2895971387 cites W2065802840 @default.
- W2895971387 cites W2065978481 @default.
- W2895971387 cites W2071473855 @default.
- W2895971387 cites W2073449985 @default.
- W2895971387 cites W2073830780 @default.
- W2895971387 cites W2074661552 @default.
- W2895971387 cites W2074869406 @default.