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- W2895973762 abstract "Nonylphenol (NP) is an endocrine-disrupting chemical (EDC) that can lead to thyroid disruption. We explored NP-induced toxicity in the rat thyroid and evaluated the mitigating effects of mulberry crude extract (MCE) on NP toxicity. First, we aimed to evaluate NP-induced thyroid disruption by dosing Sprague–Dawley (SD) rats with NP (0, 30, 90, or 270 mg/kg body weight) daily for 28 days. Second, we aimed to determine whether MCE had a detoxifying effect on NP-induced thyroid disruption by dosing SD rats with NP (270 mg/kg body weight) or/and MCE (30, 60, or 120 mg/kg body weight) daily for 28 days. We found that NP significantly inhibited free triiodothyronin (FT3) and free thyroxine (FT4) activity in rat serum (P < 0.05), but MCE intervention significantly increased FT3 and FT4 serum levels (P < 0.05). It is possible that changes in hormonal composition might trigger the TRH-TSH-TH automatic feedback loop. The activity of the three iodothyronine deiodinases increased significantly after NP-dosing (P < 0.05), but only deiodinase3 (D3) was downregulated after MCE treatment (P < 0.05). Therefore, MCE might be an effective NP-detoxification agent against thyroid disruption because it regulates D3 activity." @default.
- W2895973762 created "2018-10-26" @default.
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- W2895973762 date "2019-01-01" @default.
- W2895973762 modified "2023-10-14" @default.
- W2895973762 title "Protective effect of mulberry crude extract against nonylphenol-induced thyroid disruption by inhibiting the activity of deiodinase in rats" @default.
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- W2895973762 doi "https://doi.org/10.1016/j.ygcen.2018.10.010" @default.
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