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- W2895976300 abstract "Evidence is conflicting as to whether the use of medications with short-term adverse cognitive effects, specifically anticholinergics and benzodiazepines, may be considered modifiable risk factors for long-term cognitive decline. Here we report findings from a 4-year UK Alzheimer Society funded project addressing this topic. We performed various observational studies. We examined medication prescribing up to 20 years before dementia diagnosis using UK primary care records from 40,770 dementia cases matched to 283,933 controls of the same age and sex. The MRC Cognitive Function and Ageing Study (CFAS) was used to examine 13,004 participants from England and Wales aged over 65 years and their subsequent 10-year cognitive decline and objectively measured incident dementia. We examined medication use from 8,175 participants aged over 50 years and their subsequent 4-year cognitive decline in The Irish Longitudinal Study on Ageing (TILDA). Finally, we conducted two systematic reviews of published literature on anticholinergic and benzodiazepine use and long-term cognitive decline and dementia. We detected no association between long-term benzodiazepine use and dementia in the primary care records or CFAS. Greater dementia incidence was observed with long-term anticholinergic use, but this varied by the type of anticholinergic medication. Findings in CFAS and TILDA suggest a short-term effect of these medications on cognition. Both systematic reviews identified high risk of bias and substantial inconsistencies in the overall evidence regarding association between dementia and use of anticholinergics or benzodiazepines. In the largest studies to date, our analyses suggest that benzodiazepines and anticholinergic medications affect cognition over the short-term. We observed no long-term dementia risk with benzodiazepine use, but small associations between certain anticholinergics (antidepressants, Parkinson's disease drugs, and overactive bladder drugs) and dementia that warrant further research. This research was supported by funding from the UK Alzheimer's Society (AS-PG-2013-017)." @default.
- W2895976300 created "2018-10-26" @default.
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- W2895976300 date "2018-07-01" @default.
- W2895976300 modified "2023-10-16" @default.
- W2895976300 title "P2‐596: ANTICHOLINERGIC MEDICATIONS, BENZODIAZEPINES, AND LONG‐TERM COGNITIVE DECLINE IN LARGE OBSERVATIONAL STUDIES: FINDINGS FROM THE ANTICHOLINERGICS, BENZODIAZEPINES, COGNITION AND DEMENTIA (ABCD) STUDY" @default.
- W2895976300 doi "https://doi.org/10.1016/j.jalz.2018.06.1291" @default.
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