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- W2895976397 abstract "In this paper, experiences and learnings are shared from the 10-year application of incurred sample reanalysis (ISR) in support of the AstraZeneca small molecule portfolio. The conclusions from including ISR in every clinical bioanalysis study for a period of 5 years, generating ISR data from 550 studies, are shared. Our preclinical ISR approach is described and data generated using capillary microsampling demonstrate confidence in its routine application. The data demonstrate that ISR failures are very rare and the assessment can and should therefore be limited. Dialogue between the bioanalytical teams internally, as well as with the partner contract research organizations, is however critical for a successful bioanalytical method validation and to avoid any ISR failures." @default.
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- W2895976397 date "2018-11-01" @default.
- W2895976397 modified "2023-10-17" @default.
- W2895976397 title "Incurred sample reanalysis in AstraZeneca small molecule portfolio – what have we learned and where do we go next?" @default.
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- W2895976397 doi "https://doi.org/10.4155/bio-2018-0162" @default.
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