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- W2895977898 abstract "Abstract In this paper, we aim at discovering genetic factors of psoriasis through searching for statistically significant SNP-SNP interactions exhaustively from two real psoriasis genome-wide association study datasets (phs000019.v1.p1 and phs000982.v1.p1) downloaded from the database of Genotypes and Phenotypes. To deal with the enormous search space, our search algorithm is accelerated with eight biological plausible interaction patterns and a pre-computed look-up table. After our search, we have discovered several SNPs having a stronger association to psoriasis when they are in combination with another SNP and these combinations may be non-linear interactions. Among the top 20 SNP-SNP interactions being found in terms of pairwise p-value and improvement metric value, we have discovered 27 novel potential psoriasis-associated SNPs where most of them are reported to be eQTLs of a number of known psoriasis-associated genes. On the other hand, we have inferred a gene network after selecting the top 10000 SNP-SNP interactions in terms of improvement metric value and we have discovered a novel long distance interaction between XXbac-BPG154L12.4 and RNU6-283P which is not a long distance haplotype and may be a new discovery. Finally, our experiments with the synthetic datasets have shown that our pre-computed look-up table technique can significantly speed up the search process." @default.
- W2895977898 created "2018-10-26" @default.
- W2895977898 creator A5033225016 @default.
- W2895977898 creator A5068617123 @default.
- W2895977898 creator A5073317287 @default.
- W2895977898 creator A5088763749 @default.
- W2895977898 date "2018-10-12" @default.
- W2895977898 modified "2023-10-12" @default.
- W2895977898 title "Discovering Genetic Factors for psoriasis through exhaustively searching for significant second order SNP-SNP interactions" @default.
- W2895977898 cites W116308793 @default.
- W2895977898 cites W174185680 @default.
- W2895977898 cites W1795583523 @default.
- W2895977898 cites W1868492295 @default.
- W2895977898 cites W1968536479 @default.
- W2895977898 cites W1969208427 @default.
- W2895977898 cites W1971299565 @default.
- W2895977898 cites W1972613508 @default.
- W2895977898 cites W1974234610 @default.
- W2895977898 cites W1979134782 @default.
- W2895977898 cites W1981924240 @default.
- W2895977898 cites W1982013690 @default.
- W2895977898 cites W1985268664 @default.
- W2895977898 cites W1986124150 @default.
- W2895977898 cites W1990983602 @default.
- W2895977898 cites W1998632113 @default.
- W2895977898 cites W2006950321 @default.
- W2895977898 cites W2007062398 @default.
- W2895977898 cites W2018838463 @default.
- W2895977898 cites W2020048539 @default.
- W2895977898 cites W2028260332 @default.
- W2895977898 cites W2032840557 @default.
- W2895977898 cites W2033887258 @default.
- W2895977898 cites W2037310064 @default.
- W2895977898 cites W2039279598 @default.
- W2895977898 cites W2045113343 @default.
- W2895977898 cites W2051610296 @default.
- W2895977898 cites W2058112220 @default.
- W2895977898 cites W2066669827 @default.
- W2895977898 cites W2068966425 @default.
- W2895977898 cites W2070644791 @default.
- W2895977898 cites W2072857730 @default.
- W2895977898 cites W2076088878 @default.
- W2895977898 cites W2076633067 @default.
- W2895977898 cites W2085036051 @default.
- W2895977898 cites W2087121965 @default.
- W2895977898 cites W2091130596 @default.
- W2895977898 cites W2092940392 @default.
- W2895977898 cites W2095057511 @default.
- W2895977898 cites W2096791516 @default.
- W2895977898 cites W2105842551 @default.
- W2895977898 cites W2109130469 @default.
- W2895977898 cites W2110269506 @default.
- W2895977898 cites W2110361976 @default.
- W2895977898 cites W2111312476 @default.
- W2895977898 cites W2112966225 @default.
- W2895977898 cites W2113613985 @default.
- W2895977898 cites W2117138514 @default.
- W2895977898 cites W2119419044 @default.
- W2895977898 cites W2120361989 @default.
- W2895977898 cites W2124896761 @default.
- W2895977898 cites W2126202857 @default.
- W2895977898 cites W2132800651 @default.
- W2895977898 cites W2138048215 @default.
- W2895977898 cites W2144265655 @default.
- W2895977898 cites W2146415150 @default.
- W2895977898 cites W2150897994 @default.
- W2895977898 cites W2152905639 @default.
- W2895977898 cites W2156070536 @default.
- W2895977898 cites W2156459362 @default.
- W2895977898 cites W2156995578 @default.
- W2895977898 cites W2159930535 @default.
- W2895977898 cites W2160995259 @default.
- W2895977898 cites W2161633633 @default.
- W2895977898 cites W2163485494 @default.
- W2895977898 cites W2164533926 @default.
- W2895977898 cites W2167737986 @default.
- W2895977898 cites W2168521098 @default.
- W2895977898 cites W2174112529 @default.
- W2895977898 cites W2176753380 @default.
- W2895977898 cites W2273075340 @default.
- W2895977898 cites W2335965453 @default.
- W2895977898 cites W2344274195 @default.
- W2895977898 cites W2398958846 @default.
- W2895977898 cites W2410830904 @default.
- W2895977898 cites W2510973425 @default.
- W2895977898 cites W2560790563 @default.
- W2895977898 cites W2605395209 @default.
- W2895977898 cites W2608171249 @default.
- W2895977898 cites W2753773584 @default.
- W2895977898 cites W2758589734 @default.
- W2895977898 cites W2782573192 @default.
- W2895977898 cites W2799762305 @default.
- W2895977898 cites W962657022 @default.
- W2895977898 doi "https://doi.org/10.1038/s41598-018-33493-w" @default.
- W2895977898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6185942" @default.
- W2895977898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30315195" @default.
- W2895977898 hasPublicationYear "2018" @default.
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