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- W2895981206 abstract "There are tremendous amounts of ribosomes in rapidly proliferating cells. Native ribosomes form ordered clusters (crystals) in vitro and 2D crystals are found in vivo in eukaryotes. Recent electron microscopy studies of pro- and eukaryote cells allow the visualization of ordered arrangement of ribosomes, in vitro and in vivo. We propose that the ribosomes initiating translation are tightly bound to a compartment’s boundary. Cellular protein translation is coregulated with mRNA transcription and ribosomal biogenesis. Great progress has been made toward solving the atomic structure of the ribosome, which is the main biosynthetic machine in cells, but we still do not have a full picture of exactly how cellular ribosomes function. Based on the analysis of crystallographic and electron microscopy data, we propose a basic model of the structural organization of ribosomes into a compartment. This compartment is regularly formed by arrays of ribosomal tetramers made up of two dimers that are actually facing in opposite directions. The compartment functions as the main ‘factory’ for the production of cellular proteins. The model is consistent with the existing biochemical and genetic data. We also consider the functional connections of such a compartment with cellular transcription and ribosomal biogenesis. Great progress has been made toward solving the atomic structure of the ribosome, which is the main biosynthetic machine in cells, but we still do not have a full picture of exactly how cellular ribosomes function. Based on the analysis of crystallographic and electron microscopy data, we propose a basic model of the structural organization of ribosomes into a compartment. This compartment is regularly formed by arrays of ribosomal tetramers made up of two dimers that are actually facing in opposite directions. The compartment functions as the main ‘factory’ for the production of cellular proteins. The model is consistent with the existing biochemical and genetic data. We also consider the functional connections of such a compartment with cellular transcription and ribosomal biogenesis." @default.
- W2895981206 created "2018-10-26" @default.
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- W2895981206 date "2018-12-01" @default.
- W2895981206 modified "2023-10-06" @default.
- W2895981206 title "The Structural and Functional Organization of Ribosomal Compartment in the Cell: A Mystery or a Reality?" @default.
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- W2895981206 doi "https://doi.org/10.1016/j.tibs.2018.09.017" @default.
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