Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895981606> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2895981606 abstract "While it is increasingly recognised that sleep disturbance is common in Mild Cognitive Impairment (MCI), the specific neurophysiological processes that underpin sleep disturbance are unclear. Sleep spindles are key electroencephalogram (EEG) oscillations that occur in non-rapid eye movement (NREM) sleep, and are linked to memory processes and sleep continuity. In this study, we aim to investigate EEG power spectra in the frequency range of sleep spindles to determine whether there are differences between MCI and control subjects. We further aimed to elucidate the links between spindle frequency activity (SFA), objectively-measured sleep disturbance, and the volume of key subcortical nuclei integral to sleep and memory. Sixty participants with multi-domain MCI and 40 cognitively intact control subjects underwent comprehensive psychiatric, medical, and neuropsychological assessment, followed by overnight polysomnography. Power spectral analysis (PSA) was conducted on the sleep EEG to generate three markers of SFA: overall sigma power (12-15 Hz); slow (11-13 Hz) and fast (13-15 Hz). A subsample (n = 19 controls, n = 37 MCI) also underwent neuroimaging from which volumes of the caudate nucleus, thalamus and hippocampus were quantified. The MCI group had significantly reduced SFA in NREM sleep predominantly in the slow spindle frequency range. Reduced SFA in the MCI group was also associated with greater nocturnal awakenings. For the neuroimaging subsample, there was a statistically significant yet differential relationship between brain integrity and sigma power; for the control sample, increased SFA was associated with having smaller right thalamus and hippocampal volume. By contrast, for those with MCI, the correlation between SFA and regional volumes were not significant. Whilst sleeping, individuals with MCI exhibit pronounced alterations in the sigma frequency range, relative to controls, suggestive of altered sleep spindles. Differential relationships between sigma power and both thalamus and hippocampal volumes suggests that these structures may be linked pathophysiologically to sleep disturbance in ageing and neurodegeneration." @default.
- W2895981606 created "2018-10-26" @default.
- W2895981606 creator A5000637501 @default.
- W2895981606 creator A5001726684 @default.
- W2895981606 creator A5007003603 @default.
- W2895981606 creator A5023642117 @default.
- W2895981606 creator A5043895613 @default.
- W2895981606 creator A5062759490 @default.
- W2895981606 creator A5069774241 @default.
- W2895981606 creator A5077825658 @default.
- W2895981606 creator A5078686505 @default.
- W2895981606 date "2018-07-01" @default.
- W2895981606 modified "2023-10-16" @default.
- W2895981606 title "P2‐272: REDUCED SPINDLE FREQUENCY ACTIVITY DURING SLEEP IN MILD COGNITIVE IMPAIRMENT: DISTINCT RELATIONSHIPS WITH THALAMUS AND HIPPOCAMPUS" @default.
- W2895981606 doi "https://doi.org/10.1016/j.jalz.2018.06.961" @default.
- W2895981606 hasPublicationYear "2018" @default.
- W2895981606 type Work @default.
- W2895981606 sameAs 2895981606 @default.
- W2895981606 citedByCount "0" @default.
- W2895981606 crossrefType "journal-article" @default.
- W2895981606 hasAuthorship W2895981606A5000637501 @default.
- W2895981606 hasAuthorship W2895981606A5001726684 @default.
- W2895981606 hasAuthorship W2895981606A5007003603 @default.
- W2895981606 hasAuthorship W2895981606A5023642117 @default.
- W2895981606 hasAuthorship W2895981606A5043895613 @default.
- W2895981606 hasAuthorship W2895981606A5062759490 @default.
- W2895981606 hasAuthorship W2895981606A5069774241 @default.
- W2895981606 hasAuthorship W2895981606A5077825658 @default.
- W2895981606 hasAuthorship W2895981606A5078686505 @default.
- W2895981606 hasConcept C111919701 @default.
- W2895981606 hasConcept C14216870 @default.
- W2895981606 hasConcept C143647101 @default.
- W2895981606 hasConcept C15744967 @default.
- W2895981606 hasConcept C169760540 @default.
- W2895981606 hasConcept C169900460 @default.
- W2895981606 hasConcept C20566671 @default.
- W2895981606 hasConcept C2775841894 @default.
- W2895981606 hasConcept C2778205975 @default.
- W2895981606 hasConcept C2779246727 @default.
- W2895981606 hasConcept C2781161787 @default.
- W2895981606 hasConcept C2910364982 @default.
- W2895981606 hasConcept C41008148 @default.
- W2895981606 hasConcept C522805319 @default.
- W2895981606 hasConcept C548259974 @default.
- W2895981606 hasConcept C71924100 @default.
- W2895981606 hasConceptScore W2895981606C111919701 @default.
- W2895981606 hasConceptScore W2895981606C14216870 @default.
- W2895981606 hasConceptScore W2895981606C143647101 @default.
- W2895981606 hasConceptScore W2895981606C15744967 @default.
- W2895981606 hasConceptScore W2895981606C169760540 @default.
- W2895981606 hasConceptScore W2895981606C169900460 @default.
- W2895981606 hasConceptScore W2895981606C20566671 @default.
- W2895981606 hasConceptScore W2895981606C2775841894 @default.
- W2895981606 hasConceptScore W2895981606C2778205975 @default.
- W2895981606 hasConceptScore W2895981606C2779246727 @default.
- W2895981606 hasConceptScore W2895981606C2781161787 @default.
- W2895981606 hasConceptScore W2895981606C2910364982 @default.
- W2895981606 hasConceptScore W2895981606C41008148 @default.
- W2895981606 hasConceptScore W2895981606C522805319 @default.
- W2895981606 hasConceptScore W2895981606C548259974 @default.
- W2895981606 hasConceptScore W2895981606C71924100 @default.
- W2895981606 hasIssue "7S_Part_14" @default.
- W2895981606 hasLocation W28959816061 @default.
- W2895981606 hasOpenAccess W2895981606 @default.
- W2895981606 hasPrimaryLocation W28959816061 @default.
- W2895981606 hasRelatedWork W2001012782 @default.
- W2895981606 hasRelatedWork W2013283479 @default.
- W2895981606 hasRelatedWork W2044933377 @default.
- W2895981606 hasRelatedWork W2301667111 @default.
- W2895981606 hasRelatedWork W2311117709 @default.
- W2895981606 hasRelatedWork W2319810220 @default.
- W2895981606 hasRelatedWork W2803642516 @default.
- W2895981606 hasRelatedWork W3001920123 @default.
- W2895981606 hasRelatedWork W41640785 @default.
- W2895981606 hasRelatedWork W4221122544 @default.
- W2895981606 hasVolume "14" @default.
- W2895981606 isParatext "false" @default.
- W2895981606 isRetracted "false" @default.
- W2895981606 magId "2895981606" @default.
- W2895981606 workType "article" @default.