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• W2895982318 abstract "Cortical atrophy has been known in patients with neurodegenerative diseases including Alzheimer's disease-related cognitive impairment (ADCI) and Lewy body-related cognitive impairment (LBCI). However, the difference in the topographical atrophy pattern of these neurodegenerative diseases according to the disease stages remains poorly understood. Total 689 patients underwent 3T-MRI and standardized dementia screening procedure including Mini-Mental State Examination (MMSE). We measured the cortical thickness (CTh) using CIVET processing pipeline. Image quality and processing results were carefully verified by three neurologists. Finally, 230 ADCI patients (78 subjective cognitive decline (SCD), 75 amnestic mild cognitive impairment (MCI), 40 mild dementia (MDe), and 37 middle-to-severe dementia (SDe)) and 234 LBCI patients (68 SCD, 91 MCI, 37 MDe, and 38 SDe) were included in the statistical analysis. Firstly, we tested the relationship between MMSE and CTh. We compared the patients’ CTh in each of cognitive decline stages in each disease group. We then examined MMSE-related group differences of CTh that are centered at 2-MMSE intervals between 29 and 15. The effect of sex, age, years of education and intracranial volume were controlled. The multiple comparisons were corrected using false discovery rate (q<0.05). The MMSE score was significantly correlated with CTh in the almost entire cortex for both group, but no MMSE by group interaction effect was found (Figure 1). In ADCI group, cortical thinning was found in the entorhinal cortex and parahippocampal region even from MCI stage and widespread cortical thinning were observed in MDe and SDe stages (Figure 2). However, in LBCI group, cortical thinning was significant only in the later stage (MDe vs SDe) (Figure 3). At the 25-MMSE points, the ADCI-thinner area began to be observed in the entorhinal cortex, which spread throughout the temporal region until it reached 15 points (Figure 4). The LBCI-thinner trends were observed in the motor and cingulate regions but no vertices were significant. Cortical thinning related to cognitive decline Cortical thinning according to disease stages in ADCI patients Cortical thinning according to disease stages in LBCI patients MMSE-specific group differences in cortical thickness between LBCI and ADCI We demonstrated distinct patterns of cortical thinning in ADCI and LBCI across the disease span. Consideration of the heterogeneous atrophy patterns at different disease stages may be important when planning preventative and treatment strategies because they may have different responses to treatment and different courses of disease progression." @default.
• W2895982318 created "2018-10-26" @default.
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• W2895982318 date "2018-07-01" @default.
• W2895982318 modified "2023-10-16" @default.
• W2895982318 title "O1‐13‐05: DISTINCT PATTERN OF CORTICAL ATROPHY IN ALZHEIMER'S DISEASE‐ AND LEWY BODY‐RELATED COGNITIVE IMPAIRMENT ACROSS THE DISEASE SPAN" @default.
• W2895982318 doi "https://doi.org/10.1016/j.jalz.2018.06.3045" @default.
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