FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895982335> ?p ?o ?g. }

• W2895982335 endingPage "475" @default.
• W2895982335 startingPage "459" @default.
• W2895982335 abstract "Aims Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease characterized by progressive loss of motor neurons, muscle weakness, spasticity, paralysis and death usually within 2–5 years of onset. Neuroinflammation is a hallmark of ALS pathology characterized by activation of glial cells, which respond by upregulating small heat shock proteins (HSPBs), but the exact underlying pathological mechanisms are still largely unknown. Here, we investigated the association between ALS disease duration, lower motor neuron loss, TARDNA‐binding protein 43 (TDP‐43) pathology, neuroinflammation and HSPB expression. Methods With immunohistochemistry, we examined HSPB1, HSPB5, HSPB6, HSPB8 and HSP16.2 expression in cervical, thoracic and sacral spinal cord regions in 12 ALS cases, seven with short disease duration (SDD), five with moderate disease duration (MDD), and ten age‐matched controls. Expression was quantified using ImageJ to examine HSP expression, motor neuron numbers, microglial and astrocyte density and phosphorylated TDP‐43 (pTDP‐43+) inclusions. Results SDD was associated with elevated HSPB5 and 8 expression in lateral tract astrocytes, while HSP16.2 expression was increased in astrocytes in MDD cases. SDD cases had higher numbers of motor neurons and microglial activation than MDD cases, but similar levels of motor neurons with pTDP‐43+ inclusions. Conclusions Increased expression of several HSPBs in lateral column astrocytes suggests that astrocytes play a role in the pathogenesis of ALS. SDD is associated with increased microgliosis, HSPB5 and 8 expression in astrocytes, and only minor changes in motor neuron loss. This suggests that the interaction between motor neurons, microglia and astrocytes determines neuronal fate and functional decline in ALS." @default.
• W2895982335 created "2018-10-26" @default.
• W2895982335 creator A5002398450 @default.
• W2895982335 creator A5005548202 @default.
• W2895982335 creator A5013794797 @default.
• W2895982335 creator A5021808164 @default.
• W2895982335 creator A5022104066 @default.
• W2895982335 creator A5033448398 @default.
• W2895982335 creator A5040695453 @default.
• W2895982335 creator A5041611622 @default.
• W2895982335 creator A5046803783 @default.
• W2895982335 creator A5081853428 @default.
• W2895982335 creator A5087105783 @default.
• W2895982335 creator A5087173779 @default.
• W2895982335 date "2018-11-23" @default.
• W2895982335 modified "2023-09-30" @default.
• W2895982335 title "Rapidly progressive amyotrophic lateral sclerosis is associated with microglial reactivity and small heat shock protein expression in reactive astrocytes" @default.
• W2895982335 cites W1971233962 @default.
• W2895982335 cites W1971516308 @default.
• W2895982335 cites W1972518511 @default.
• W2895982335 cites W1979229843 @default.
• W2895982335 cites W1986723919 @default.
• W2895982335 cites W1986953518 @default.
• W2895982335 cites W1988787774 @default.
• W2895982335 cites W1991970246 @default.
• W2895982335 cites W1997815565 @default.
• W2895982335 cites W2022814422 @default.
• W2895982335 cites W2024882157 @default.
• W2895982335 cites W2032706712 @default.
• W2895982335 cites W2035368278 @default.
• W2895982335 cites W2039458533 @default.
• W2895982335 cites W2043608718 @default.
• W2895982335 cites W2055493310 @default.
• W2895982335 cites W2059037137 @default.
• W2895982335 cites W2072523239 @default.
• W2895982335 cites W2077831889 @default.
• W2895982335 cites W2079312451 @default.
• W2895982335 cites W2089400513 @default.
• W2895982335 cites W2096439716 @default.
• W2895982335 cites W2107401597 @default.
• W2895982335 cites W2111812550 @default.
• W2895982335 cites W2116896548 @default.
• W2895982335 cites W2130565053 @default.
• W2895982335 cites W2141261198 @default.
• W2895982335 cites W2164426059 @default.
• W2895982335 cites W2167279371 @default.
• W2895982335 cites W2237695503 @default.
• W2895982335 cites W2290136674 @default.
• W2895982335 cites W2342256681 @default.
• W2895982335 cites W2344992440 @default.
• W2895982335 cites W2370677464 @default.
• W2895982335 cites W2588541017 @default.
• W2895982335 cites W2596238655 @default.
• W2895982335 cites W2598518812 @default.
• W2895982335 cites W2599825252 @default.
• W2895982335 cites W2605303518 @default.
• W2895982335 cites W2607829140 @default.
• W2895982335 cites W2611011337 @default.
• W2895982335 cites W2616337968 @default.
• W2895982335 cites W2751255298 @default.
• W2895982335 cites W2753338351 @default.
• W2895982335 cites W2754226141 @default.
• W2895982335 cites W2755186712 @default.
• W2895982335 cites W2761403361 @default.
• W2895982335 cites W2788797941 @default.
• W2895982335 cites W2792809925 @default.
• W2895982335 cites W2895982335 @default.
• W2895982335 cites W2913609543 @default.
• W2895982335 cites W4210998205 @default.
• W2895982335 doi "https://doi.org/10.1111/nan.12525" @default.
• W2895982335 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7379307" @default.
• W2895982335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30346063" @default.
• W2895982335 hasPublicationYear "2018" @default.
• W2895982335 type Work @default.
• W2895982335 sameAs 2895982335 @default.
• W2895982335 citedByCount "19" @default.
• W2895982335 countsByYear W28959823352018 @default.
• W2895982335 countsByYear W28959823352019 @default.
• W2895982335 countsByYear W28959823352020 @default.
• W2895982335 countsByYear W28959823352021 @default.
• W2895982335 countsByYear W28959823352022 @default.
• W2895982335 countsByYear W28959823352023 @default.
• W2895982335 crossrefType "journal-article" @default.
• W2895982335 hasAuthorship W2895982335A5002398450 @default.
• W2895982335 hasAuthorship W2895982335A5005548202 @default.
• W2895982335 hasAuthorship W2895982335A5013794797 @default.
• W2895982335 hasAuthorship W2895982335A5021808164 @default.
• W2895982335 hasAuthorship W2895982335A5022104066 @default.
• W2895982335 hasAuthorship W2895982335A5033448398 @default.
• W2895982335 hasAuthorship W2895982335A5040695453 @default.
• W2895982335 hasAuthorship W2895982335A5041611622 @default.
• W2895982335 hasAuthorship W2895982335A5046803783 @default.
• W2895982335 hasAuthorship W2895982335A5081853428 @default.
• W2895982335 hasAuthorship W2895982335A5087105783 @default.
• W2895982335 hasAuthorship W2895982335A5087173779 @default.
• W2895982335 hasBestOaLocation W28959823352 @default.
• W2895982335 hasConcept C142724271 @default.
• W2895982335 hasConcept C157207234 @default.

• next