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• W2895982370 abstract "In previous studies, CRISPR/Cas9 was shown to induce unexpected exon skipping; however, the mechanism by which this phenomenon is triggered is controversial. By analyzing 22 gene-edited rabbit lines generated using CRISPR/Cas9, we provide evidence of exon skipping at high frequency in premature termination codon-mutated rabbits but not in the rabbits with a premature termination codon mutation in exon 1 rabbits with non-frameshift or missense mutations. Our results suggest that CRISPR-mediated exon skipping depends on premature termination codon mutation-induced nonsense-associated altered splicing." @default.
• W2895982370 created "2018-10-26" @default.
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• W2895982370 date "2018-10-17" @default.
• W2895982370 modified "2023-10-02" @default.
• W2895982370 title "CRISPR-induced exon skipping is dependent on premature termination codon mutations" @default.
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• W2895982370 doi "https://doi.org/10.1186/s13059-018-1532-z" @default.
• W2895982370 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6193291" @default.
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