FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895982634> ?p ?o ?g. }

• W2895982634 endingPage "e722" @default.
• W2895982634 startingPage "e722" @default.
• W2895982634 abstract "To prospectively evaluate the effectiveness, toxicity and cognitive function of hippocampal-sparing prophylactic cranial irradiation(HS-PCI) in patients with small-cell lung cancer by using helical Tomotherapy(HT). Between April 2014 and March 2017, 49 Patients with SCLC, achieving a complete response to chemoradiotherapy and no brain metastases, were eligible. The hippocampus was contoured, and hippocampal avoidance regions were created using a 3mm volumetric expansion around the hippocampus. Patients received PCI 25 Gy/10 fractions, with a mean hippocampal dose limited to <8 Gy. The toxicity, cranial metastasis, neurocognitive function of patients will be evaluated. The cognitive function measured by the Hopkins Verbal Learning Test-Revised and Mini-mental State Examination at 6 months and 12months after PCI. HT spared the hippocampus and expansion around the hippocampus with 7.23Gy and 8.46Gy. hippocampal dose was reduced to 71.88% and 66.16% to compare with Prescription doses. Hippocampal maximum dose was 10.66Gy. 8 patients were dead. 1-year and 2-year survival rate were 85.1% and 70.3%. 9 patients occurred brain metastases（18.3%）. None >3 grade toxicity was observed. The toxicity was mainly headache, dizziness, hair loss reactions. No significant decline in MMSE(minimum-mental state examination) scores was observed(29.42,29.25,29.10score,p=0.337,0.212). After 1 year from treatment, the HVLT score was relatively decline 6.78% (19.90, 18.65, p=0.001) compared with pretreatment score. However, there were no significant decline of HVLT score in the patients without brain metastases（p=0.763). This study suggests a potential benefit of hippocampal-sparing PCI in SCLC patients with rates of brain and hippocampal metastases consistent with standard PCI. Further research and long-term observation was required." @default.
• W2895982634 created "2018-10-26" @default.
• W2895982634 creator A5001837422 @default.
• W2895982634 creator A5003046062 @default.
• W2895982634 creator A5009048277 @default.
• W2895982634 creator A5021315269 @default.
• W2895982634 creator A5021773274 @default.
• W2895982634 creator A5025362732 @default.
• W2895982634 creator A5025805006 @default.
• W2895982634 creator A5028509674 @default.
• W2895982634 creator A5032605795 @default.
• W2895982634 creator A5035642707 @default.
• W2895982634 creator A5037284116 @default.
• W2895982634 creator A5067851667 @default.
• W2895982634 creator A5073644384 @default.
• W2895982634 creator A5077437724 @default.
• W2895982634 creator A5082433156 @default.
• W2895982634 creator A5089768060 @default.
• W2895982634 date "2018-11-01" @default.
• W2895982634 modified "2023-10-18" @default.
• W2895982634 title "Hippocampal-Sparing Prophylactic Cranial Irradiation in Small Cell Lung Cancer: A Phase II Clinical Trial" @default.
• W2895982634 doi "https://doi.org/10.1016/j.ijrobp.2018.07.1938" @default.
• W2895982634 hasPublicationYear "2018" @default.
• W2895982634 type Work @default.
• W2895982634 sameAs 2895982634 @default.
• W2895982634 citedByCount "2" @default.
• W2895982634 countsByYear W28959826342021 @default.
• W2895982634 countsByYear W28959826342022 @default.
• W2895982634 crossrefType "journal-article" @default.
• W2895982634 hasAuthorship W2895982634A5001837422 @default.
• W2895982634 hasAuthorship W2895982634A5003046062 @default.
• W2895982634 hasAuthorship W2895982634A5009048277 @default.
• W2895982634 hasAuthorship W2895982634A5021315269 @default.
• W2895982634 hasAuthorship W2895982634A5021773274 @default.
• W2895982634 hasAuthorship W2895982634A5025362732 @default.
• W2895982634 hasAuthorship W2895982634A5025805006 @default.
• W2895982634 hasAuthorship W2895982634A5028509674 @default.
• W2895982634 hasAuthorship W2895982634A5032605795 @default.
• W2895982634 hasAuthorship W2895982634A5035642707 @default.
• W2895982634 hasAuthorship W2895982634A5037284116 @default.
• W2895982634 hasAuthorship W2895982634A5067851667 @default.
• W2895982634 hasAuthorship W2895982634A5073644384 @default.
• W2895982634 hasAuthorship W2895982634A5077437724 @default.
• W2895982634 hasAuthorship W2895982634A5082433156 @default.
• W2895982634 hasAuthorship W2895982634A5089768060 @default.
• W2895982634 hasBestOaLocation W28959826341 @default.
• W2895982634 hasConcept C118552586 @default.
• W2895982634 hasConcept C126322002 @default.
• W2895982634 hasConcept C141071460 @default.
• W2895982634 hasConcept C148762608 @default.
• W2895982634 hasConcept C169900460 @default.
• W2895982634 hasConcept C172467417 @default.
• W2895982634 hasConcept C2776256026 @default.
• W2895982634 hasConcept C2778424827 @default.
• W2895982634 hasConcept C2779562246 @default.
• W2895982634 hasConcept C2781161787 @default.
• W2895982634 hasConcept C29730261 @default.
• W2895982634 hasConcept C2989005 @default.
• W2895982634 hasConcept C42219234 @default.
• W2895982634 hasConcept C45393284 @default.
• W2895982634 hasConcept C500558357 @default.
• W2895982634 hasConcept C509974204 @default.
• W2895982634 hasConcept C71924100 @default.
• W2895982634 hasConceptScore W2895982634C118552586 @default.
• W2895982634 hasConceptScore W2895982634C126322002 @default.
• W2895982634 hasConceptScore W2895982634C141071460 @default.
• W2895982634 hasConceptScore W2895982634C148762608 @default.
• W2895982634 hasConceptScore W2895982634C169900460 @default.
• W2895982634 hasConceptScore W2895982634C172467417 @default.
• W2895982634 hasConceptScore W2895982634C2776256026 @default.
• W2895982634 hasConceptScore W2895982634C2778424827 @default.
• W2895982634 hasConceptScore W2895982634C2779562246 @default.
• W2895982634 hasConceptScore W2895982634C2781161787 @default.
• W2895982634 hasConceptScore W2895982634C29730261 @default.
• W2895982634 hasConceptScore W2895982634C2989005 @default.
• W2895982634 hasConceptScore W2895982634C42219234 @default.
• W2895982634 hasConceptScore W2895982634C45393284 @default.
• W2895982634 hasConceptScore W2895982634C500558357 @default.
• W2895982634 hasConceptScore W2895982634C509974204 @default.
• W2895982634 hasConceptScore W2895982634C71924100 @default.
• W2895982634 hasIssue "3" @default.
• W2895982634 hasLocation W28959826341 @default.
• W2895982634 hasOpenAccess W2895982634 @default.
• W2895982634 hasPrimaryLocation W28959826341 @default.
• W2895982634 hasRelatedWork W1546955416 @default.
• W2895982634 hasRelatedWork W1967526654 @default.
• W2895982634 hasRelatedWork W2371911254 @default.
• W2895982634 hasRelatedWork W2570634367 @default.
• W2895982634 hasRelatedWork W2592344251 @default.
• W2895982634 hasRelatedWork W2795935567 @default.
• W2895982634 hasRelatedWork W2939403674 @default.
• W2895982634 hasRelatedWork W3139643096 @default.
• W2895982634 hasRelatedWork W3208642710 @default.
• W2895982634 hasRelatedWork W4288067512 @default.
• W2895982634 hasVolume "102" @default.
• W2895982634 isParatext "false" @default.
• W2895982634 isRetracted "false" @default.
• W2895982634 magId "2895982634" @default.

• next