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- W2895983393 abstract "Peroxisomal biogenesis factor PEX26 is a membrane anchor for the multi-subunit PEX1-PEX6 protein complex that controls ubiquitination and dislocation of PEX5 cargo receptors for peroxisomal matrix protein import. PEX26 associates with the peroxisomal translocation pore via PEX14 and a splice variant (PEX26Δex5) of unknown function has been reported. Here, we demonstrate PEX26 homooligomerization mediated by two heptad repeat domains adjacent to the transmembrane domain. We show that isoform-specific domain organization determines PEX26 oligomerization and impacts peroxisomal β-oxidation and proliferation. PEX26 and PEX26Δex5 displayed different patterns of interaction with PEX2-PEX10 or PEX13-PEX14 complexes, which relate to distinct pre-peroxisomes in the de novo synthesis pathway. Our data support an alternative PEX14-dependent mechanism of peroxisomal membrane association for the splice variant, which lacks a transmembrane domain. Structure-function relationships of PEX26 isoforms explain an extended function in peroxisomal homeostasis and these findings may improve our understanding of the broad phenotype of PEX26-associated human disorders." @default.
- W2895983393 created "2018-10-26" @default.
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- W2895983393 date "2019-03-01" @default.
- W2895983393 modified "2023-09-26" @default.
- W2895983393 title "Isoform-specific domain organization determines conformation and function of the peroxisomal biogenesis factor PEX26" @default.
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- W2895983393 cites W1649401556 @default.
- W2895983393 cites W185136262 @default.
- W2895983393 cites W1931576697 @default.
- W2895983393 cites W1973555864 @default.
- W2895983393 cites W1976257128 @default.
- W2895983393 cites W1977187874 @default.
- W2895983393 cites W1979157121 @default.
- W2895983393 cites W1979249349 @default.
- W2895983393 cites W1981089167 @default.
- W2895983393 cites W1982251004 @default.
- W2895983393 cites W1983882766 @default.
- W2895983393 cites W1986308794 @default.
- W2895983393 cites W1986699793 @default.
- W2895983393 cites W1996277355 @default.
- W2895983393 cites W1997566863 @default.
- W2895983393 cites W1998843625 @default.
- W2895983393 cites W2003432454 @default.
- W2895983393 cites W2004262571 @default.
- W2895983393 cites W2004424136 @default.
- W2895983393 cites W2007886762 @default.
- W2895983393 cites W2013503779 @default.
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- W2895983393 cites W2016728319 @default.
- W2895983393 cites W2020044496 @default.
- W2895983393 cites W2025890979 @default.
- W2895983393 cites W2037312364 @default.
- W2895983393 cites W2042591952 @default.
- W2895983393 cites W2046742125 @default.
- W2895983393 cites W2056139558 @default.
- W2895983393 cites W2066896766 @default.
- W2895983393 cites W2068711980 @default.
- W2895983393 cites W2079694858 @default.
- W2895983393 cites W2081869877 @default.
- W2895983393 cites W2089605287 @default.
- W2895983393 cites W2089981605 @default.
- W2895983393 cites W2090022626 @default.
- W2895983393 cites W2096536472 @default.
- W2895983393 cites W2098539652 @default.
- W2895983393 cites W2101169749 @default.
- W2895983393 cites W2101641567 @default.
- W2895983393 cites W2114535339 @default.
- W2895983393 cites W2129888211 @default.
- W2895983393 cites W2131851433 @default.
- W2895983393 cites W2132762612 @default.
- W2895983393 cites W2137450588 @default.
- W2895983393 cites W2145419446 @default.
- W2895983393 cites W2155362213 @default.
- W2895983393 cites W2162701589 @default.
- W2895983393 cites W2164071427 @default.
- W2895983393 cites W2165534020 @default.
- W2895983393 cites W2168974130 @default.
- W2895983393 cites W2170298138 @default.
- W2895983393 cites W2173276475 @default.
- W2895983393 cites W2192140425 @default.
- W2895983393 cites W2201477213 @default.
- W2895983393 cites W2209919074 @default.
- W2895983393 cites W2263982485 @default.
- W2895983393 cites W2270260451 @default.
- W2895983393 cites W2291570439 @default.
- W2895983393 cites W2427135010 @default.
- W2895983393 cites W2581248702 @default.
- W2895983393 cites W2585343016 @default.
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- W2895983393 cites W2797472953 @default.
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- W2895983393 doi "https://doi.org/10.1016/j.bbamcr.2018.10.013" @default.
- W2895983393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30366024" @default.
- W2895983393 hasPublicationYear "2019" @default.
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