FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895984359> ?p ?o ?g. }

• W2895984359 endingPage "366" @default.
• W2895984359 startingPage "358" @default.
• W2895984359 abstract "Background: The regional chronomodulated hepatic arterial infusion chemotherapy (HAIC) is an effective regimen for the treatment of patients with unresectable liver metastases from colorectal cancer, especially for the conversion into resectability. Aim: To demonstrate that chronomodulated HAI triplet chemotherapy according to OPTILIV protocol is well tolerated and displayed high antitumor activity in this heavily-pretreated patient. Case Presentation: A 54 years old patient from Russia was treated for a tumor in the ascending colon presented with 13 hepatic metastases ranging from 0.3 to 2.7 cm in diameter. He underwent a laparoscopic right hemicolectomy, 12 cycles of FOLFIRINOX combined to bevacizumab for the last 5 cycles, resulting in a partial response according to CT scan. It was decided to perform a two-stage hepatectomy at Paul Brousse hospital: left partial hepatectomy allowed the excision of 9 lesions. Radio frequency ablation was performed in 2 nodular lesions. Afterwards, the patient received 5 cycles of chronomodulated triplet chemotherapy into the hepatic artery, according to the OPTILIV protocol design, yet without cetuximab, because of the KRAS mutation in the liver metastases, with a partial re-sponse. The patient could then undergo the second stage of the planned right hepatectomy, which turned out to be an R0 resection followed by receiving three courses of chronomodulated HAIC. Disease progression was documented after 3 months. Chronomodulated FOLFIRI chemotherapy was re-started intravenously, in combination with Aflibercept and it was associated with further disease progression. The genetic analysis of our patient’s cancer revealed a high level of MSI. The patient was included in the Phase 2 CheckMate-142 trial and received nivolumab 3 mg/kg every 2 weeks within 3 months. Treatment was discontinued due to ineffectiveness. Then the patient underwent radiotherapy geared towards reduction of pain. Afterwards, the patient died from the disease progression 2 years after the beginning of treatment. Conclusion: In this article, the authors report a clinical case with chronomodulated HAIC as rescue therapy in a heavily pretreated patient with metastatic colorectal cancer, allowing to achieve an objective response despite prior progression on FOLFIRINOX (the same triplet chemo by IV route). This strategy permitted to overcome drug resistance and to perform further complete resection of the liver me-tastases with prolonged patient survival. Thus, chronomodulated HAI is useful in patients with liver metastases from colorectal cancer and de-serves to be further assessed prospectively in clinical trials chemotherapy." @default.
• W2895984359 created "2018-10-26" @default.
• W2895984359 creator A5000726989 @default.
• W2895984359 creator A5012325306 @default.
• W2895984359 creator A5037937397 @default.
• W2895984359 creator A5038139440 @default.
• W2895984359 creator A5052686564 @default.
• W2895984359 creator A5078259466 @default.
• W2895984359 creator A5080012080 @default.
• W2895984359 creator A5088122891 @default.
• W2895984359 date "2018-01-01" @default.
• W2895984359 modified "2023-10-18" @default.
• W2895984359 title "Conversion of Unresectable to Resectable Liver Metastases from Colorectal Carcinoma Using Hepatic Arterial Chronomodulated Chemotherapy: A Case Report and Short Literature Review" @default.
• W2895984359 cites W1940241680 @default.
• W2895984359 cites W1985113284 @default.
• W2895984359 cites W1986924507 @default.
• W2895984359 cites W1992484131 @default.
• W2895984359 cites W2044224410 @default.
• W2895984359 cites W2079190855 @default.
• W2895984359 cites W2085773264 @default.
• W2895984359 cites W2087455610 @default.
• W2895984359 cites W2108585052 @default.
• W2895984359 cites W2128643078 @default.
• W2895984359 cites W2137900825 @default.
• W2895984359 cites W2165948908 @default.
• W2895984359 cites W2167676775 @default.
• W2895984359 cites W2174652897 @default.
• W2895984359 cites W2461852561 @default.
• W2895984359 cites W2520338075 @default.
• W2895984359 cites W2531319683 @default.
• W2895984359 cites W2538328947 @default.
• W2895984359 cites W2543412381 @default.
• W2895984359 cites W2598731928 @default.
• W2895984359 cites W2739132742 @default.
• W2895984359 cites W2747856781 @default.
• W2895984359 cites W2126157274 @default.
• W2895984359 doi "https://doi.org/10.4236/ss.2018.910043" @default.
• W2895984359 hasPublicationYear "2018" @default.
• W2895984359 type Work @default.
• W2895984359 sameAs 2895984359 @default.
• W2895984359 citedByCount "0" @default.
• W2895984359 crossrefType "journal-article" @default.
• W2895984359 hasAuthorship W2895984359A5000726989 @default.
• W2895984359 hasAuthorship W2895984359A5012325306 @default.
• W2895984359 hasAuthorship W2895984359A5037937397 @default.
• W2895984359 hasAuthorship W2895984359A5038139440 @default.
• W2895984359 hasAuthorship W2895984359A5052686564 @default.
• W2895984359 hasAuthorship W2895984359A5078259466 @default.
• W2895984359 hasAuthorship W2895984359A5080012080 @default.
• W2895984359 hasAuthorship W2895984359A5088122891 @default.
• W2895984359 hasBestOaLocation W28959843591 @default.
• W2895984359 hasConcept C121608353 @default.
• W2895984359 hasConcept C126322002 @default.
• W2895984359 hasConcept C143998085 @default.
• W2895984359 hasConcept C2776694085 @default.
• W2895984359 hasConcept C526805850 @default.
• W2895984359 hasConcept C61434518 @default.
• W2895984359 hasConcept C71924100 @default.
• W2895984359 hasConcept C90924648 @default.
• W2895984359 hasConceptScore W2895984359C121608353 @default.
• W2895984359 hasConceptScore W2895984359C126322002 @default.
• W2895984359 hasConceptScore W2895984359C143998085 @default.
• W2895984359 hasConceptScore W2895984359C2776694085 @default.
• W2895984359 hasConceptScore W2895984359C526805850 @default.
• W2895984359 hasConceptScore W2895984359C61434518 @default.
• W2895984359 hasConceptScore W2895984359C71924100 @default.
• W2895984359 hasConceptScore W2895984359C90924648 @default.
• W2895984359 hasIssue "10" @default.
• W2895984359 hasLocation W28959843591 @default.
• W2895984359 hasOpenAccess W2895984359 @default.
• W2895984359 hasPrimaryLocation W28959843591 @default.
• W2895984359 hasRelatedWork W1908989187 @default.
• W2895984359 hasRelatedWork W1971638713 @default.
• W2895984359 hasRelatedWork W2037724349 @default.
• W2895984359 hasRelatedWork W2465617904 @default.
• W2895984359 hasRelatedWork W2502269149 @default.
• W2895984359 hasRelatedWork W2547796148 @default.
• W2895984359 hasRelatedWork W2808934676 @default.
• W2895984359 hasRelatedWork W2907419770 @default.
• W2895984359 hasRelatedWork W4205934876 @default.
• W2895984359 hasRelatedWork W4229076162 @default.
• W2895984359 hasVolume "09" @default.
• W2895984359 isParatext "false" @default.
• W2895984359 isRetracted "false" @default.
• W2895984359 magId "2895984359" @default.
• W2895984359 workType "article" @default.