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- W2895985720 abstract "The thymus has been associated with chromosomal abnormalities like DiGeorge Syndrome and now there are reports of association with prolonged premature rupture of membranes and intrauterine growth restriction (IUGR). We have carried out this study to establish a normal reference range of fetal thymus measurement in uncomplicated pregnancy of the thymus anteroposterior thickness (APT) in second trimester of pregnancy by 2D ultrasound in Indian fetuses. The present study is prospective and cross sectional. The anteroposterior thickness of thymus was measured by the midline between aorta posteriorly to the posterior chest wall anteriorly in consecutive normal fetuses between 18 to 28 weeks of gestation using GE Volusion E10-BT/E8-BT 13.5 ultrasound device with a transabdominal C5-9, 9L, RAB6-D transducers at Paras Advanced Centre for Fetal Medicine between January 2017 and September 2017. Fetal thymus measurement normogram were developed by measuring anteroposterior thickness of fetal thymus and linear regression curve was developed. A total of 330 normal fetuses were included. APT increased with increasing gestational age in a linear manner. Regression equations were μ = 0.018x2 + 0.0857x - 1.1389 and SD = -0.0107x2 + 0.646x - 7.6211 respectively. The predicted mean and 1st, 5th, 10th, 50th, 90th, 95th and 99th centile reference ranges of TTD at each gestational age are shown in graph below. We have created a normogram for thymic APT on 2D-US in Indian fetuses of 18-28 week of gestation. This will help us identify a possible association with Di-George syndrome and Trisomy 18 and 21. Supporting information can be found in the online version of this abstract Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
- W2895985720 created "2018-10-26" @default.
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- W2895985720 date "2018-10-01" @default.
- W2895985720 modified "2023-10-18" @default.
- W2895985720 title "EP05.07: Anteroposterior thickness of thymus in second trimester of pregnancy measured by 2D ultrasound: normogram for Indian population" @default.
- W2895985720 doi "https://doi.org/10.1002/uog.19837" @default.
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