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- W2895985886 endingPage "32" @default.
- W2895985886 startingPage "20" @default.
- W2895985886 abstract "Icariin is a major active component of the traditional herb Epimedium, also known as Horny Goat Weed. It has been extensively studied throughout the past several years and is known to exert anti-oxidative, anti-neuroinflammatory, and anti-apoptotic effects. It is now being considered as a potential therapeutic agent for a wide variety of disorders, ranging from neoplasm to cardiovascular disease. More recent studies have shown that icariin exhibits potential preventive and/or therapeutic effects in the nervous system. For example, icariin can prevent the production of amyloid β (1−42) and inhibit the expression of amyloid precursor protein (APP) and β-site APP cleaving enzyme 1 (BACE-1) in animal models of Alzheimer's disease (AD). Icariin has been shown to mitigate pro-inflammatory responses of microglia in culture and in animal models of cerebral ischemia, depression, Parkinson's disease (PD), and multiple sclerosis (MS). Icariin also prevents the neurotoxicity induced by hydrogen peroxide (H2O2), endoplasmic reticulum (ER) stress, ibotenic acid, and homocysteine. In addition, icariin is implicated in facilitating learning and memory in both normal aging animals and disease models. To date, we still have no consolidated source of knowledge about the pharmacological effects of icariin in the nervous system, though its roles in other tissues have been reviewed in recent years. Here, we summarize the pharmacological development of icariin as well as its possible mechanisms in prevention and/or therapy of disorders afflicting the nervous system in hope of expanding the knowledge about the preventive and/or therapeutic effect of icariin in brain disorders." @default.
- W2895985886 created "2018-10-26" @default.
- W2895985886 creator A5000276702 @default.
- W2895985886 creator A5017825677 @default.
- W2895985886 creator A5028813896 @default.
- W2895985886 creator A5047488872 @default.
- W2895985886 creator A5084380346 @default.
- W2895985886 creator A5090366405 @default.
- W2895985886 date "2019-01-01" @default.
- W2895985886 modified "2023-10-16" @default.
- W2895985886 title "An outline for the pharmacological effect of icariin in the nervous system" @default.
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