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- W2896005284 abstract "Weight loss in AD is associated with dementia severity and faster clinical progression. Epidemiological studies suggest a complex relationship between body composition and dementia that may be variable across the age-spectrum. Body composition is measured using bioelectrical impedance analysis (BIA), and correlation between the result of BIA and cognitive function is analyzed. A total of 118 elderly (46 male, 72 female) were recruited. They were divided into three groups; normal (n=33), mild cognitive impairment(MCI) (n=42), and Alzheimer's disease(AD) (n=43) according to the diagnostic criteria. Skeletal muscle mass, body fat mass, and fat-free mass were measured using a BIA device, and were converted to the ratio of body weight. All participants underwent MMSE-K. In Pearson correlation analysis, skeletal muscle percentage(SMP) and fat-free mass percentage(FFMP) were positively correlated with MMSE-K score (r = 0.309, p = 0.001; r = 0.245, p = 0.008), and body fat percentage was negatively correlated (r = -0.258, p = 0.005). In multiple regression analysis, SMP (β = 2.012, t = 4.457, p <0.001) and FFMP (β = -1.733, t = -3.838, p <0.001) were selected as the best predictors of changes in MMSE-K score (R2 = 0.198). Reduced skeletal muscle and increased body fat correlate with decreased cognitive function, suggesting the need for prevention of frailty and early diagnosis of cognitive impairment." @default.
- W2896005284 created "2018-10-26" @default.
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- W2896005284 date "2018-07-01" @default.
- W2896005284 modified "2023-10-16" @default.
- W2896005284 title "P4‐177: RELATIONSHIP BETWEEN BODY COMPOSITION AND COGNITIVE FUNCTION: USING BIOELECTRICAL IMPEDANCE ANALYSIS" @default.
- W2896005284 doi "https://doi.org/10.1016/j.jalz.2018.06.2582" @default.
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