Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896008749> ?p ?o ?g. }
- W2896008749 endingPage "e12649" @default.
- W2896008749 startingPage "e12649" @default.
- W2896008749 abstract "Changes of neurosteroids may be involved in the pathophysiology of multiple sclerosis (MS). The present study investigated whether changes of neurosteroidogenesis also occurred in the grey and white matter regions of the brain in mice subjected to cuprizone-induced demyelination. Accordingly, we compared the expression of neurosteroidogenic proteins, including steroidogenic acute regulatory protein (StAR), voltage-dependent anion channel (VDAC) and 18 kDa translocator protein (TSPO), as well as neurosteroidogenic enzymes, including the side chain cleavage enzyme (P450scc), 3β-hydroxysteroid dehydrogenase/isomerase and 5α-reductase (5α-R), during the demyelination and remyelination periods. Using immunohistochemistry and a quantitative polymerase chain reaction, we demonstrated a decreased expression of StAR, P450scc and 5α-R with respect to an increase astrocytic and microglial reaction and elevated levels of tumor necrosis factor (TNF)α during the cuprizone demyelination period in the hippocampus, cortex and corpus callosum. These parameters, as well as the glial reaction, were normalised after 2 weeks of spontaneous remyelination in regions containing grey matter. Conversely, persistent elevated levels of TNFα and low levels of StAR and P450scc were observed during remyelination in corpus callosum white matter. We conclude that neurosteroidogenesis/myelination status and glial reactivity are inversely related in the hippocampus and neocortex. Establishing a cause and effect relationship for the measured variables remains a future challenge for understanding the pathophysiology of MS." @default.
- W2896008749 created "2018-10-26" @default.
- W2896008749 creator A5029189004 @default.
- W2896008749 creator A5033533800 @default.
- W2896008749 creator A5049945506 @default.
- W2896008749 creator A5073343470 @default.
- W2896008749 creator A5075378899 @default.
- W2896008749 creator A5076181016 @default.
- W2896008749 creator A5078575387 @default.
- W2896008749 date "2018-10-31" @default.
- W2896008749 modified "2023-10-18" @default.
- W2896008749 title "Changes in neurosteroidogenesis during demyelination and remyelination in cuprizone-treated mice" @default.
- W2896008749 cites W1494051921 @default.
- W2896008749 cites W1856705702 @default.
- W2896008749 cites W1981889317 @default.
- W2896008749 cites W1985690685 @default.
- W2896008749 cites W1988729104 @default.
- W2896008749 cites W1991932320 @default.
- W2896008749 cites W1992919675 @default.
- W2896008749 cites W1994096100 @default.
- W2896008749 cites W1995445966 @default.
- W2896008749 cites W1997026847 @default.
- W2896008749 cites W2001133344 @default.
- W2896008749 cites W2006178657 @default.
- W2896008749 cites W2006430695 @default.
- W2896008749 cites W2006618367 @default.
- W2896008749 cites W2007438030 @default.
- W2896008749 cites W2007710484 @default.
- W2896008749 cites W2010764455 @default.
- W2896008749 cites W2014389746 @default.
- W2896008749 cites W2019415782 @default.
- W2896008749 cites W2023548331 @default.
- W2896008749 cites W2023667812 @default.
- W2896008749 cites W2028641661 @default.
- W2896008749 cites W2030496214 @default.
- W2896008749 cites W2032844562 @default.
- W2896008749 cites W2039299884 @default.
- W2896008749 cites W2045672832 @default.
- W2896008749 cites W2047690697 @default.
- W2896008749 cites W2055910116 @default.
- W2896008749 cites W2057071461 @default.
- W2896008749 cites W2057752710 @default.
- W2896008749 cites W2058317490 @default.
- W2896008749 cites W2068621428 @default.
- W2896008749 cites W2071703252 @default.
- W2896008749 cites W2071946866 @default.
- W2896008749 cites W2076275302 @default.
- W2896008749 cites W2078890238 @default.
- W2896008749 cites W2079590635 @default.
- W2896008749 cites W2080944497 @default.
- W2896008749 cites W2082058677 @default.
- W2896008749 cites W2083877922 @default.
- W2896008749 cites W2085405074 @default.
- W2896008749 cites W2088951671 @default.
- W2896008749 cites W2089154573 @default.
- W2896008749 cites W2092919008 @default.
- W2896008749 cites W2094231537 @default.
- W2896008749 cites W2100512410 @default.
- W2896008749 cites W2100904149 @default.
- W2896008749 cites W2105448036 @default.
- W2896008749 cites W2107066201 @default.
- W2896008749 cites W2116653422 @default.
- W2896008749 cites W2122860707 @default.
- W2896008749 cites W2128833728 @default.
- W2896008749 cites W2133905389 @default.
- W2896008749 cites W2136912880 @default.
- W2896008749 cites W2147238535 @default.
- W2896008749 cites W2153674879 @default.
- W2896008749 cites W2157275878 @default.
- W2896008749 cites W2158156478 @default.
- W2896008749 cites W2165888339 @default.
- W2896008749 cites W2190725993 @default.
- W2896008749 cites W2204392591 @default.
- W2896008749 cites W2265965451 @default.
- W2896008749 cites W2319459971 @default.
- W2896008749 cites W2407637892 @default.
- W2896008749 cites W2517035816 @default.
- W2896008749 cites W2553427810 @default.
- W2896008749 cites W2561493056 @default.
- W2896008749 cites W2582762559 @default.
- W2896008749 cites W2597900136 @default.
- W2896008749 cites W2610289618 @default.
- W2896008749 cites W2727448372 @default.
- W2896008749 cites W2735193465 @default.
- W2896008749 cites W2739439369 @default.
- W2896008749 cites W2750331912 @default.
- W2896008749 cites W2756682690 @default.
- W2896008749 cites W2767502255 @default.
- W2896008749 cites W2767654192 @default.
- W2896008749 cites W2770280684 @default.
- W2896008749 cites W2770590892 @default.
- W2896008749 cites W2781935316 @default.
- W2896008749 cites W4322695807 @default.
- W2896008749 doi "https://doi.org/10.1111/jne.12649" @default.
- W2896008749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30303567" @default.
- W2896008749 hasPublicationYear "2018" @default.
- W2896008749 type Work @default.
- W2896008749 sameAs 2896008749 @default.