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- W2896009029 abstract "Silica nanoparticles (SiNPs) have been used as vehicles for drug delivery, molecular detection, and cellular manipulations in nanoneuromedicine. SiNPs may cause adverse effects in the brain including neurotoxicity, neuroinflammation, neurodegeneration, and enhancing levels of amyloid beta (Aβ) protein—all pathological hallmarks of Alzheimer’s disease. Therefore, the extent to which SiNPs influence Aβ generation and the underlying mechanisms by which this occurs deserve investigation. Our studies were focused on the effects of SiNPs on endolysosomes which uptake, traffic, and mediate the actions of SiNPs. These organelles are also where amyloidogenesis largely originates. We found that SiNPs, in primary cultured hippocampal neurons, accumulated in endolysosomes and caused a rapid and persistent deacidification of endolysosomes. SiNPs significantly reduced endolysosome calcium stores as indicated by a significant reduction in the ability of the lysosomotropic agent glycyl-l-phenylalanine 2-naphthylamide (GPN) to release calcium from endolysosomes. SiNPs increased Aβ 1–40 secretion, whereas 2 agents that acidified endolysosomes, ML-SA1 and CGS21680, blocked SiNP-induced deacidification and increased generation of Aβ 1–40 . Our findings suggest that SiNP-induced deacidification of and calcium release from endolysosomes might be mechanistically linked to increased amyloidogenesis. The use of SiNPs might not be the best nanomaterial for therapeutic strategies against Alzheimer’s disease and other neurological disorders linked to endolysosome dysfunction." @default.
- W2896009029 created "2018-10-26" @default.
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- W2896009029 date "2019-04-01" @default.
- W2896009029 modified "2023-10-18" @default.
- W2896009029 title "Effects of silica nanoparticles on endolysosome function in primary cultured neurons" @default.
- W2896009029 cites W1414886268 @default.
- W2896009029 cites W1479897400 @default.
- W2896009029 cites W1571118981 @default.
- W2896009029 cites W1791904161 @default.
- W2896009029 cites W1803199265 @default.
- W2896009029 cites W18034176 @default.
- W2896009029 cites W1892400228 @default.
- W2896009029 cites W1964730685 @default.
- W2896009029 cites W1965987889 @default.
- W2896009029 cites W1968921200 @default.
- W2896009029 cites W1971018930 @default.
- W2896009029 cites W1972394237 @default.
- W2896009029 cites W1974788688 @default.
- W2896009029 cites W1976278209 @default.
- W2896009029 cites W1980605491 @default.
- W2896009029 cites W1981937857 @default.
- W2896009029 cites W1982498393 @default.
- W2896009029 cites W1984872272 @default.
- W2896009029 cites W1989735320 @default.
- W2896009029 cites W1994344429 @default.
- W2896009029 cites W1996784261 @default.
- W2896009029 cites W2000604662 @default.
- W2896009029 cites W2001548424 @default.
- W2896009029 cites W2001561235 @default.
- W2896009029 cites W2011300465 @default.
- W2896009029 cites W2011432266 @default.
- W2896009029 cites W2015792401 @default.
- W2896009029 cites W2016983155 @default.
- W2896009029 cites W2017196579 @default.
- W2896009029 cites W2018140585 @default.
- W2896009029 cites W2022990556 @default.
- W2896009029 cites W2028440527 @default.
- W2896009029 cites W2028685883 @default.
- W2896009029 cites W2031095496 @default.
- W2896009029 cites W2032778209 @default.
- W2896009029 cites W2033460128 @default.
- W2896009029 cites W2034621134 @default.
- W2896009029 cites W2038668099 @default.
- W2896009029 cites W2039187058 @default.
- W2896009029 cites W2045372790 @default.
- W2896009029 cites W2049815829 @default.
- W2896009029 cites W2051070651 @default.
- W2896009029 cites W2055182511 @default.
- W2896009029 cites W2055776993 @default.
- W2896009029 cites W2056636594 @default.
- W2896009029 cites W2057610600 @default.
- W2896009029 cites W2061347886 @default.
- W2896009029 cites W2061436416 @default.
- W2896009029 cites W2063618791 @default.
- W2896009029 cites W2067273125 @default.
- W2896009029 cites W2069498930 @default.
- W2896009029 cites W2078292613 @default.
- W2896009029 cites W2080983287 @default.
- W2896009029 cites W2087812848 @default.
- W2896009029 cites W2094618353 @default.
- W2896009029 cites W2097631517 @default.
- W2896009029 cites W2100918077 @default.
- W2896009029 cites W2104757714 @default.
- W2896009029 cites W2111423624 @default.
- W2896009029 cites W2119141725 @default.
- W2896009029 cites W2128101513 @default.
- W2896009029 cites W2130002810 @default.
- W2896009029 cites W2133772521 @default.
- W2896009029 cites W2143376609 @default.
- W2896009029 cites W2145133103 @default.
- W2896009029 cites W2152462290 @default.
- W2896009029 cites W2152752812 @default.
- W2896009029 cites W2155385159 @default.
- W2896009029 cites W2157016784 @default.
- W2896009029 cites W2161147260 @default.
- W2896009029 cites W2163132978 @default.
- W2896009029 cites W2173405668 @default.
- W2896009029 cites W2238531003 @default.
- W2896009029 cites W2287823367 @default.
- W2896009029 cites W2351208027 @default.
- W2896009029 cites W2514496288 @default.
- W2896009029 cites W2563612827 @default.
- W2896009029 cites W4213174091 @default.
- W2896009029 cites W4255480785 @default.
- W2896009029 doi "https://doi.org/10.1139/cjpp-2018-0401" @default.
- W2896009029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6443500" @default.
- W2896009029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30312546" @default.
- W2896009029 hasPublicationYear "2019" @default.
- W2896009029 type Work @default.
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