Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896009316> ?p ?o ?g. }
- W2896009316 endingPage "1805557" @default.
- W2896009316 startingPage "1805557" @default.
- W2896009316 abstract "Macrophages hold great potential in cancer drug delivery because they can sense chemotactic cues and home to tumors with high efficiency. However, it remains a challenge to load large amounts of therapeutics into macrophages without compromising cell functions. This study reports a silica-based drug nanocapsule approach to solve this issue. The nanocapsule consists of a drug-silica complex filling and a solid silica sheath, and it is designed to minimally release drug molecules in the early hours of cell entry. While taken up by macrophages at high rates, the nanocapsules minimally affect cell migration in the first 6-12 h, buying time for macrophages to home to tumors and release drugs in situ. In particular, it is shown that doxorubicin (Dox) as a representative drug can be loaded into macrophages up to 16.6 pg per cell using this approach. When tested in a U87MG xenograft model, intravenously (i.v.) injected Dox-laden macrophages show comparable tumor accumulation as untreated macrophages. Therapy leads to efficient tumor growth suppression, while causing little systematic toxicity. This study suggests a new cell platform for selective drug delivery, which can be readily extended to the treatment of other types of diseases." @default.
- W2896009316 created "2018-10-26" @default.
- W2896009316 creator A5024846442 @default.
- W2896009316 creator A5033128707 @default.
- W2896009316 creator A5035939791 @default.
- W2896009316 creator A5036925342 @default.
- W2896009316 creator A5038929593 @default.
- W2896009316 creator A5039338731 @default.
- W2896009316 creator A5041486785 @default.
- W2896009316 creator A5045893552 @default.
- W2896009316 creator A5049067213 @default.
- W2896009316 creator A5052588272 @default.
- W2896009316 creator A5062689107 @default.
- W2896009316 creator A5070297217 @default.
- W2896009316 creator A5073222321 @default.
- W2896009316 creator A5077161968 @default.
- W2896009316 creator A5083421271 @default.
- W2896009316 creator A5086573133 @default.
- W2896009316 creator A5090366405 @default.
- W2896009316 date "2018-10-11" @default.
- W2896009316 modified "2023-10-18" @default.
- W2896009316 title "Nanoparticle‐Laden Macrophages for Tumor‐Tropic Drug Delivery" @default.
- W2896009316 cites W1566386955 @default.
- W2896009316 cites W1914131546 @default.
- W2896009316 cites W1965037168 @default.
- W2896009316 cites W1966687725 @default.
- W2896009316 cites W1971218073 @default.
- W2896009316 cites W1980052502 @default.
- W2896009316 cites W1982094144 @default.
- W2896009316 cites W1982246664 @default.
- W2896009316 cites W1987021433 @default.
- W2896009316 cites W2001717792 @default.
- W2896009316 cites W2011896471 @default.
- W2896009316 cites W2013875757 @default.
- W2896009316 cites W2026185209 @default.
- W2896009316 cites W2028434426 @default.
- W2896009316 cites W2034074846 @default.
- W2896009316 cites W2041401460 @default.
- W2896009316 cites W2041454553 @default.
- W2896009316 cites W2044352000 @default.
- W2896009316 cites W2054472394 @default.
- W2896009316 cites W2056014360 @default.
- W2896009316 cites W2063441983 @default.
- W2896009316 cites W2068217608 @default.
- W2896009316 cites W2081581508 @default.
- W2896009316 cites W2088549024 @default.
- W2896009316 cites W2097261404 @default.
- W2896009316 cites W2100042000 @default.
- W2896009316 cites W2115583652 @default.
- W2896009316 cites W2123903182 @default.
- W2896009316 cites W2124723818 @default.
- W2896009316 cites W2127898787 @default.
- W2896009316 cites W2135561906 @default.
- W2896009316 cites W2136945827 @default.
- W2896009316 cites W2227069948 @default.
- W2896009316 cites W2324117139 @default.
- W2896009316 cites W2324198878 @default.
- W2896009316 cites W2333132726 @default.
- W2896009316 cites W2405899780 @default.
- W2896009316 cites W2406375428 @default.
- W2896009316 cites W2462090026 @default.
- W2896009316 cites W2517651674 @default.
- W2896009316 cites W2567613753 @default.
- W2896009316 cites W2586769321 @default.
- W2896009316 cites W2613352698 @default.
- W2896009316 cites W2620019303 @default.
- W2896009316 cites W2638561866 @default.
- W2896009316 cites W2170379439 @default.
- W2896009316 doi "https://doi.org/10.1002/adma.201805557" @default.
- W2896009316 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6506271" @default.
- W2896009316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30368972" @default.
- W2896009316 hasPublicationYear "2018" @default.
- W2896009316 type Work @default.
- W2896009316 sameAs 2896009316 @default.
- W2896009316 citedByCount "135" @default.
- W2896009316 countsByYear W28960093162019 @default.
- W2896009316 countsByYear W28960093162020 @default.
- W2896009316 countsByYear W28960093162021 @default.
- W2896009316 countsByYear W28960093162022 @default.
- W2896009316 countsByYear W28960093162023 @default.
- W2896009316 crossrefType "journal-article" @default.
- W2896009316 hasAuthorship W2896009316A5024846442 @default.
- W2896009316 hasAuthorship W2896009316A5033128707 @default.
- W2896009316 hasAuthorship W2896009316A5035939791 @default.
- W2896009316 hasAuthorship W2896009316A5036925342 @default.
- W2896009316 hasAuthorship W2896009316A5038929593 @default.
- W2896009316 hasAuthorship W2896009316A5039338731 @default.
- W2896009316 hasAuthorship W2896009316A5041486785 @default.
- W2896009316 hasAuthorship W2896009316A5045893552 @default.
- W2896009316 hasAuthorship W2896009316A5049067213 @default.
- W2896009316 hasAuthorship W2896009316A5052588272 @default.
- W2896009316 hasAuthorship W2896009316A5062689107 @default.
- W2896009316 hasAuthorship W2896009316A5070297217 @default.
- W2896009316 hasAuthorship W2896009316A5073222321 @default.
- W2896009316 hasAuthorship W2896009316A5077161968 @default.
- W2896009316 hasAuthorship W2896009316A5083421271 @default.
- W2896009316 hasAuthorship W2896009316A5086573133 @default.
- W2896009316 hasAuthorship W2896009316A5090366405 @default.