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• W2896020715 abstract "Unisexual reproduction is widespread among lower vertebrates, but not in mammals. Deletion of the H19 imprinted region in immature oocytes produced bimaternal mice with defective growth; however, bipaternal reproduction has not been previously achieved in mammals. We found that cultured parthenogenetic and androgenetic haploid embryonic stem cells (haESCs) display DNA hypomethylation resembling that of primordial germ cells. Through MII oocyte injection or sperm coinjection with hypomethylated haploid ESCs carrying specific imprinted region deletions, we obtained live bimaternal and bipaternal mice. Deletion of 3 imprinted regions in parthenogenetic haploid ESCs restored normal growth of fertile bimaternal mice, whereas deletion of 7 imprinted regions in androgenetic haploid ESCs enabled production of live bipaternal mice that died shortly after birth. Phenotypic analyses of organ and body size of these mice support the genetic conflict theory of genomic imprinting. Taken together, our results highlight the factors necessary for crossing same-sex reproduction barriers in mammals." @default.
• W2896020715 created "2018-10-26" @default.
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• W2896020715 date "2018-11-01" @default.
• W2896020715 modified "2023-10-16" @default.
• W2896020715 title "Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions" @default.
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• W2896020715 cites W1965277298 @default.
• W2896020715 cites W1971764800 @default.
• W2896020715 cites W1972298775 @default.
• W2896020715 cites W1973842956 @default.
• W2896020715 cites W1978386737 @default.
• W2896020715 cites W1982352752 @default.
• W2896020715 cites W1983350119 @default.
• W2896020715 cites W1984077980 @default.
• W2896020715 cites W1989253200 @default.
• W2896020715 cites W1989854187 @default.
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• W2896020715 cites W1997372839 @default.
• W2896020715 cites W1997667014 @default.
• W2896020715 cites W1998525496 @default.
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• W2896020715 cites W2000819178 @default.
• W2896020715 cites W2005942028 @default.
• W2896020715 cites W2006557744 @default.
• W2896020715 cites W2011108720 @default.
• W2896020715 cites W2021469360 @default.
• W2896020715 cites W2022710905 @default.
• W2896020715 cites W2022867908 @default.
• W2896020715 cites W2023527508 @default.
• W2896020715 cites W2039298424 @default.
• W2896020715 cites W2050384177 @default.
• W2896020715 cites W2051068182 @default.
• W2896020715 cites W2053309035 @default.
• W2896020715 cites W2054191153 @default.
• W2896020715 cites W2071976775 @default.
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• W2896020715 cites W2085547889 @default.
• W2896020715 cites W2086444514 @default.
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• W2896020715 doi "https://doi.org/10.1016/j.stem.2018.09.004" @default.
• W2896020715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30318303" @default.
• W2896020715 hasPublicationYear "2018" @default.
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