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- W2896021036 endingPage "197" @default.
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- W2896021036 abstract "Bilirubin-induced brain injury in the neonatal period has detrimental effects on neurodevelopment that persist into childhood and adulthood, contributing to childhood developmental disorders. Unconjugated bilirubin is a potent antioxidant that may be useful for protecting against oxidative injuries, but it becomes a potent neurotoxin once it crosses the blood brain barrier. Because bilirubin toxicity involves a myriad of pathological mechanisms, can damage most types of brain cells, and affects brain circuits or loops that influence cognition, learning, behavior, sensory, and language, the clinical effects of bilirubin-induced neurotoxicity are likely to be manifold. One possible effect that several experts have identified is bilirubin-induced neurological dysfunction (subtle kernicterus). However, the underlying biological mechanisms or pathways by which subtle kernicterus could lead to developmental disorders has not been elucidated previously. Our aim in this review is to describe a spectrum of developmental disorders that may reflect subtle kernicterus and outline plausible biological mechanisms for this possible association. We review existing evidence that support or refute the association between unconjugated hyperbilirubinemia and developmental disorders, and limitations associated with these studies." @default.
- W2896021036 created "2018-10-26" @default.
- W2896021036 creator A5002712603 @default.
- W2896021036 creator A5080756501 @default.
- W2896021036 creator A5084609542 @default.
- W2896021036 date "2018-10-23" @default.
- W2896021036 modified "2023-10-17" @default.
- W2896021036 title "Developmental influence of unconjugated hyperbilirubinemia and neurobehavioral disorders" @default.
- W2896021036 cites W1481744522 @default.
- W2896021036 cites W1483217552 @default.
- W2896021036 cites W1498096105 @default.
- W2896021036 cites W1521745746 @default.
- W2896021036 cites W1530884851 @default.
- W2896021036 cites W1542503274 @default.
- W2896021036 cites W1583309920 @default.
- W2896021036 cites W1586037868 @default.
- W2896021036 cites W1587010377 @default.
- W2896021036 cites W1606661507 @default.
- W2896021036 cites W1868780445 @default.
- W2896021036 cites W1906182678 @default.
- W2896021036 cites W1916064374 @default.
- W2896021036 cites W1925181037 @default.
- W2896021036 cites W1934915055 @default.
- W2896021036 cites W1940606697 @default.
- W2896021036 cites W1964320082 @default.
- W2896021036 cites W1964977883 @default.
- W2896021036 cites W1965402434 @default.
- W2896021036 cites W1965996037 @default.
- W2896021036 cites W1969073775 @default.
- W2896021036 cites W1970006557 @default.
- W2896021036 cites W1970904547 @default.
- W2896021036 cites W1971553391 @default.
- W2896021036 cites W1972539504 @default.
- W2896021036 cites W1983384871 @default.
- W2896021036 cites W1987237170 @default.
- W2896021036 cites W1987466926 @default.
- W2896021036 cites W1988070929 @default.
- W2896021036 cites W1988598615 @default.
- W2896021036 cites W1991119987 @default.
- W2896021036 cites W1992881443 @default.
- W2896021036 cites W1999661952 @default.
- W2896021036 cites W2002175599 @default.
- W2896021036 cites W2002654991 @default.
- W2896021036 cites W2006414608 @default.
- W2896021036 cites W2007804932 @default.
- W2896021036 cites W2007817385 @default.
- W2896021036 cites W2009541780 @default.
- W2896021036 cites W2012424455 @default.
- W2896021036 cites W2014641174 @default.
- W2896021036 cites W2016693709 @default.
- W2896021036 cites W2019568399 @default.
- W2896021036 cites W2019905574 @default.
- W2896021036 cites W2020374636 @default.
- W2896021036 cites W2022084936 @default.
- W2896021036 cites W2023999463 @default.
- W2896021036 cites W2029674895 @default.
- W2896021036 cites W2031462364 @default.
- W2896021036 cites W2033714047 @default.
- W2896021036 cites W2034769207 @default.
- W2896021036 cites W2038750793 @default.
- W2896021036 cites W2039729702 @default.
- W2896021036 cites W2044029293 @default.
- W2896021036 cites W2046266986 @default.
- W2896021036 cites W2052175052 @default.
- W2896021036 cites W2056178569 @default.
- W2896021036 cites W2056223081 @default.
- W2896021036 cites W2058734237 @default.
- W2896021036 cites W2061207218 @default.
- W2896021036 cites W2063139184 @default.
- W2896021036 cites W2064569489 @default.
- W2896021036 cites W2064863416 @default.
- W2896021036 cites W2067319141 @default.
- W2896021036 cites W2067821063 @default.
- W2896021036 cites W2068948958 @default.
- W2896021036 cites W2069594214 @default.
- W2896021036 cites W2070076555 @default.
- W2896021036 cites W2071642274 @default.
- W2896021036 cites W2074189236 @default.
- W2896021036 cites W2075364936 @default.
- W2896021036 cites W2075495488 @default.
- W2896021036 cites W2075801228 @default.
- W2896021036 cites W2079968536 @default.
- W2896021036 cites W2083035916 @default.
- W2896021036 cites W2085913927 @default.
- W2896021036 cites W2089367656 @default.
- W2896021036 cites W2090901626 @default.
- W2896021036 cites W2092139032 @default.
- W2896021036 cites W2092535419 @default.
- W2896021036 cites W2094651717 @default.
- W2896021036 cites W2096240659 @default.
- W2896021036 cites W2099652807 @default.
- W2896021036 cites W2100969228 @default.
- W2896021036 cites W2105863262 @default.
- W2896021036 cites W2108205869 @default.
- W2896021036 cites W2111563892 @default.
- W2896021036 cites W2111994312 @default.
- W2896021036 cites W2112675479 @default.
- W2896021036 cites W2113428932 @default.