FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896022059> ?p ?o ?g. }

• W2896022059 endingPage "836" @default.
• W2896022059 startingPage "828" @default.
• W2896022059 abstract "Abstract Background Constitutional loss of function (LOF) single nucleotide polymorphisms (SNPs) in pattern recognition receptors FPR1, TLR3, and TLR4 have previously been reported to predict oxaliplatin benefit in colorectal cancer. Confirmation of this association could substantially improve patient stratification. Methods We performed a retrospective biomarker analysis of the Short Course in Oncology Therapy (SCOT) and COIN/COIN-B trials. Participant status for LOF variants in FPR1 (rs867228), TLR3 (rs3775291), and TLR4 (rs4986790/rs4986791) was determined by genotyping array or genotype imputation. Associations between LOF variants and disease-free survival (DFS) and overall survival (OS) were analyzed by Cox regression, adjusted for confounders, using additive, dominant, and recessive genetic models. All statistical tests were two-sided. Results Our validation study populations included 2929 and 1948 patients in the SCOT and COIN/COIN-B cohorts, respectively, of whom 2728 and 1672 patients had functional status of all three SNPs determined. We found no evidence of an association between any SNP and DFS in the SCOT cohort, or with OS in either cohort, irrespective of the type of model used. This included models for which an association was previously reported for rs867228 (recessive model, multivariable-adjusted hazard ratio [HR] for DFS in SCOT = 1.19, 95% confidence interval [CI] = 0.99 to 1.45, P = .07; HR for OS in COIN/COIN-B = 0.92, 95% CI = 0.63 to 1.34, P = .66), and rs4986790 (dominant model, multivariable-adjusted HR for DFS in SCOT = 0.86, 95% CI = 0.65 to 1.13, P = .27; HR for OS in COIN/COIN-B = 1.08, 95% CI = 0.90 to 1.31, P = .40). Conclusion In this prespecified analysis of two large clinical trials, we found no evidence that constitutional LOF SNPs in FPR1, TLR3, or TLR4 are associated with differential benefit from oxaliplatin. Our results suggest these SNPs are unlikely to be clinically useful biomarkers." @default.
• W2896022059 created "2018-10-26" @default.
• W2896022059 creator A5004647151 @default.
• W2896022059 creator A5005335753 @default.
• W2896022059 creator A5012742637 @default.
• W2896022059 creator A5023018025 @default.
• W2896022059 creator A5023124963 @default.
• W2896022059 creator A5026575327 @default.
• W2896022059 creator A5027152344 @default.
• W2896022059 creator A5030461033 @default.
• W2896022059 creator A5031677626 @default.
• W2896022059 creator A5034457278 @default.
• W2896022059 creator A5035563046 @default.
• W2896022059 creator A5040081800 @default.
• W2896022059 creator A5040598662 @default.
• W2896022059 creator A5044388356 @default.
• W2896022059 creator A5053866155 @default.
• W2896022059 creator A5053919588 @default.
• W2896022059 creator A5054875746 @default.
• W2896022059 creator A5069612368 @default.
• W2896022059 creator A5076768636 @default.
• W2896022059 creator A5080479952 @default.
• W2896022059 creator A5083960633 @default.
• W2896022059 creator A5086034841 @default.
• W2896022059 creator A5087404367 @default.
• W2896022059 creator A5088658336 @default.
• W2896022059 date "2019-01-14" @default.
• W2896022059 modified "2023-10-18" @default.
• W2896022059 title "Pattern Recognition Receptor Polymorphisms as Predictors of Oxaliplatin Benefit in Colorectal Cancer" @default.
• W2896022059 cites W1907868928 @default.
• W2896022059 cites W1911271782 @default.
• W2896022059 cites W1940833630 @default.
• W2896022059 cites W1987754412 @default.
• W2896022059 cites W1995003386 @default.
• W2896022059 cites W2042433863 @default.
• W2896022059 cites W2061539393 @default.
• W2896022059 cites W2071301649 @default.
• W2896022059 cites W2079379555 @default.
• W2896022059 cites W2091103707 @default.
• W2896022059 cites W2091286879 @default.
• W2896022059 cites W2093424661 @default.
• W2896022059 cites W2096151993 @default.
• W2896022059 cites W2096910745 @default.
• W2896022059 cites W2119938514 @default.
• W2896022059 cites W2124451268 @default.
• W2896022059 cites W2130153302 @default.
• W2896022059 cites W2139248078 @default.
• W2896022059 cites W2142300779 @default.
• W2896022059 cites W2144798655 @default.
• W2896022059 cites W2145070131 @default.
• W2896022059 cites W2149791927 @default.
• W2896022059 cites W2157752701 @default.
• W2896022059 cites W2161633633 @default.
• W2896022059 cites W2171232394 @default.
• W2896022059 cites W2213473402 @default.
• W2896022059 cites W2256016639 @default.
• W2896022059 cites W2397189416 @default.
• W2896022059 cites W2547630624 @default.
• W2896022059 cites W2794889098 @default.
• W2896022059 cites W4252714226 @default.
• W2896022059 doi "https://doi.org/10.1093/jnci/djy215" @default.
• W2896022059 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6695319" @default.
• W2896022059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30649440" @default.
• W2896022059 hasPublicationYear "2019" @default.
• W2896022059 type Work @default.
• W2896022059 sameAs 2896022059 @default.
• W2896022059 citedByCount "10" @default.
• W2896022059 countsByYear W28960220592019 @default.
• W2896022059 countsByYear W28960220592020 @default.
• W2896022059 countsByYear W28960220592021 @default.
• W2896022059 countsByYear W28960220592022 @default.
• W2896022059 countsByYear W28960220592023 @default.
• W2896022059 crossrefType "journal-article" @default.
• W2896022059 hasAuthorship W2896022059A5004647151 @default.
• W2896022059 hasAuthorship W2896022059A5005335753 @default.
• W2896022059 hasAuthorship W2896022059A5012742637 @default.
• W2896022059 hasAuthorship W2896022059A5023018025 @default.
• W2896022059 hasAuthorship W2896022059A5023124963 @default.
• W2896022059 hasAuthorship W2896022059A5026575327 @default.
• W2896022059 hasAuthorship W2896022059A5027152344 @default.
• W2896022059 hasAuthorship W2896022059A5030461033 @default.
• W2896022059 hasAuthorship W2896022059A5031677626 @default.
• W2896022059 hasAuthorship W2896022059A5034457278 @default.
• W2896022059 hasAuthorship W2896022059A5035563046 @default.
• W2896022059 hasAuthorship W2896022059A5040081800 @default.
• W2896022059 hasAuthorship W2896022059A5040598662 @default.
• W2896022059 hasAuthorship W2896022059A5044388356 @default.
• W2896022059 hasAuthorship W2896022059A5053866155 @default.
• W2896022059 hasAuthorship W2896022059A5053919588 @default.
• W2896022059 hasAuthorship W2896022059A5054875746 @default.
• W2896022059 hasAuthorship W2896022059A5069612368 @default.
• W2896022059 hasAuthorship W2896022059A5076768636 @default.
• W2896022059 hasAuthorship W2896022059A5080479952 @default.
• W2896022059 hasAuthorship W2896022059A5083960633 @default.
• W2896022059 hasAuthorship W2896022059A5086034841 @default.
• W2896022059 hasAuthorship W2896022059A5087404367 @default.
• W2896022059 hasAuthorship W2896022059A5088658336 @default.
• W2896022059 hasBestOaLocation W28960220591 @default.

• next