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• W2896026997 abstract "Background: Angiosarcoma is a rare malignancy, and the data about its clinicopathological features and prognostic factors are limited. The purpose of this study was to present a retrospective analysis of angiosarcoma patients treated at a single institution. Methods: Clinical and pathological features of 41 patients treated in our institution between 1998 and 2016 were analyzed. Results: Of the 41 patients included, 53.7% were women and 46,3% were men and median age was 60 (16-81). 34.1% cases were located in the soft tissues (ST) of the limbs or trunk, 24.4% in the viscera (V), 19.5% in the breast (B), 14.6% involved the head and neck (HN) and 7.3% in the bone (B). The overall survival (OS) at 5 years was 26% (IC: 15% - 42%), with a median survival of 14.9 months. For the 17.1% patients that were alive at the time of analysis, the median follow up was 60 months (16.1-222.1).The tumor sites for the 7 surivors involved B(4), ST(1), HN(1) and V(1). Radiation induced angiosarcoma was suspected in 17.1% patients. Chronic lymphedema was described/highly probable for 19.5% of the patients. Surgery(S) was performed in 82.9% cases, chemotherapy(CT) in 41.5% cases, and radiation therapy(RT) for 9.8% of cases. CT was more likely to be given to younger patients, but did not improve OS. The pathology report was uncertain for 39% cases at first examination. Superficial tumors (B, ST and HN) had a better OS than deep tumors (V,B) but not statistically significant (31%vs15%). Women had a significant better OS compared to men (36%vs16%, p = 0.02). OS at 5 years for patients under age 67 was 30%, and 17% for patients above 67 (p = 0.07). Tumor grade was assesed for 85.4% cases. Grade 1(G1) was found in 12.2%, G2 in 36.6% and G3 in 36.6% patients. Patients having G3 tumors had a lower OS, but not statistically significant. Relapse occured at 58.5% of the patients (from 1 to 4 episodes). Of all relapses, 68.3% occured locally, 7.3% regionally, and 48.8% were distant metastases. The most common metastatic sites were lung (7 cases), bone (4), skin (4) and liver (3). Conclusions: Angiosarcoma is an agressive tumor that was often underrecognized, occuring in various sites. Women with history of radiotherapy or lymphedema are at higher risk, but have a better prognosis. Younger patients and lower grade seem to have a longer survival. Legal entity responsible for the study: Chirila Monica-Emilia. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest." @default.
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• W2896026997 date "2018-10-01" @default.
• W2896026997 modified "2023-09-27" @default.
• W2896026997 title "Outcomes and prognostic factors for angiosarcoma: A 19-year single institution experience" @default.
• W2896026997 doi "https://doi.org/10.1093/annonc/mdy299.049" @default.
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