Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896032060> ?p ?o ?g. }
- W2896032060 abstract "Abstract Long-term estrogen deprivation (LTED) of an estrogen receptor (ER) α-positive breast cancer cell line recapitulates cancer cells that have acquired estrogen-independent cell proliferation and endocrine therapy resistance. Previously, we have shown that a cluster of non-coding RNAs, Eleanors ( ESR1 locus enhancing and activating non-coding RNAs ) formed RNA cloud and upregulated the ESR1 gene in the nuclei of LTED cells. Eleanors were inhibited by resveratrol through ER. Here we prepared another polyphenol, glyceollin I from stressed soybeans, and identified it as a major inhibitor of the Eleanor RNA cloud and ESR1 mRNA transcription. The inhibition was independent of ER, unlike one by resveratrol. This was consistent with a distinct tertiary structure of glyceollin I for ER binding. Glyceollin I preferentially inhibited the growth of LTED cells and induced apoptosis. Our results suggest that glyceollin I has a novel role in LTED cell inhibition through Eleanors . In other words, LTED cells or endocrine therapy-resistant breast cancer cells may be ready for apoptosis, which can be triggered with polyphenols both in ER-dependent and ER-independent manners." @default.
- W2896032060 created "2018-10-26" @default.
- W2896032060 creator A5005769469 @default.
- W2896032060 creator A5007855678 @default.
- W2896032060 creator A5013963270 @default.
- W2896032060 creator A5023167310 @default.
- W2896032060 creator A5029230024 @default.
- W2896032060 creator A5030399533 @default.
- W2896032060 creator A5036405854 @default.
- W2896032060 creator A5042093626 @default.
- W2896032060 creator A5078266078 @default.
- W2896032060 creator A5078951089 @default.
- W2896032060 date "2018-10-12" @default.
- W2896032060 modified "2023-09-26" @default.
- W2896032060 title "Endocrine therapy-resistant breast cancer model cells are inhibited by soybean glyceollin I through Eleanor non-coding RNA" @default.
- W2896032060 cites W1505814592 @default.
- W2896032060 cites W1508224111 @default.
- W2896032060 cites W1965041083 @default.
- W2896032060 cites W2001617382 @default.
- W2896032060 cites W2006708160 @default.
- W2896032060 cites W2007425597 @default.
- W2896032060 cites W2013956549 @default.
- W2896032060 cites W2024415595 @default.
- W2896032060 cites W2028691872 @default.
- W2896032060 cites W2033344337 @default.
- W2896032060 cites W2035504218 @default.
- W2896032060 cites W2041799604 @default.
- W2896032060 cites W2049495967 @default.
- W2896032060 cites W2050032075 @default.
- W2896032060 cites W2060760516 @default.
- W2896032060 cites W2060857762 @default.
- W2896032060 cites W2064239185 @default.
- W2896032060 cites W2068152759 @default.
- W2896032060 cites W2070212927 @default.
- W2896032060 cites W2081491080 @default.
- W2896032060 cites W2083734586 @default.
- W2896032060 cites W2087459011 @default.
- W2896032060 cites W2088902203 @default.
- W2896032060 cites W2095513100 @default.
- W2896032060 cites W2103151254 @default.
- W2896032060 cites W2108326951 @default.
- W2896032060 cites W2109600062 @default.
- W2896032060 cites W2109737489 @default.
- W2896032060 cites W2135060880 @default.
- W2896032060 cites W2142945152 @default.
- W2896032060 cites W2145474242 @default.
- W2896032060 cites W2158038535 @default.
- W2896032060 cites W2164800803 @default.
- W2896032060 cites W2167399292 @default.
- W2896032060 cites W2169988894 @default.
- W2896032060 cites W2202583381 @default.
- W2896032060 cites W2315368724 @default.
- W2896032060 cites W2322204065 @default.
- W2896032060 cites W2332059976 @default.
- W2896032060 cites W2400886455 @default.
- W2896032060 cites W2512945634 @default.
- W2896032060 cites W2734306112 @default.
- W2896032060 cites W2765643657 @default.
- W2896032060 doi "https://doi.org/10.1038/s41598-018-33227-y" @default.
- W2896032060 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6185934" @default.
- W2896032060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30315184" @default.
- W2896032060 hasPublicationYear "2018" @default.
- W2896032060 type Work @default.
- W2896032060 sameAs 2896032060 @default.
- W2896032060 citedByCount "19" @default.
- W2896032060 countsByYear W28960320602018 @default.
- W2896032060 countsByYear W28960320602019 @default.
- W2896032060 countsByYear W28960320602020 @default.
- W2896032060 countsByYear W28960320602021 @default.
- W2896032060 countsByYear W28960320602022 @default.
- W2896032060 countsByYear W28960320602023 @default.
- W2896032060 crossrefType "journal-article" @default.
- W2896032060 hasAuthorship W2896032060A5005769469 @default.
- W2896032060 hasAuthorship W2896032060A5007855678 @default.
- W2896032060 hasAuthorship W2896032060A5013963270 @default.
- W2896032060 hasAuthorship W2896032060A5023167310 @default.
- W2896032060 hasAuthorship W2896032060A5029230024 @default.
- W2896032060 hasAuthorship W2896032060A5030399533 @default.
- W2896032060 hasAuthorship W2896032060A5036405854 @default.
- W2896032060 hasAuthorship W2896032060A5042093626 @default.
- W2896032060 hasAuthorship W2896032060A5078266078 @default.
- W2896032060 hasAuthorship W2896032060A5078951089 @default.
- W2896032060 hasBestOaLocation W28960320601 @default.
- W2896032060 hasConcept C104317684 @default.
- W2896032060 hasConcept C105580179 @default.
- W2896032060 hasConcept C121608353 @default.
- W2896032060 hasConcept C126322002 @default.
- W2896032060 hasConcept C127561419 @default.
- W2896032060 hasConcept C134018914 @default.
- W2896032060 hasConcept C172313692 @default.
- W2896032060 hasConcept C185592680 @default.
- W2896032060 hasConcept C2777164284 @default.
- W2896032060 hasConcept C502942594 @default.
- W2896032060 hasConcept C530470458 @default.
- W2896032060 hasConcept C55493867 @default.
- W2896032060 hasConcept C62112901 @default.
- W2896032060 hasConcept C67705224 @default.
- W2896032060 hasConcept C71924100 @default.
- W2896032060 hasConcept C84606932 @default.
- W2896032060 hasConcept C86803240 @default.