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• W2896032634 abstract "Although the tumorigenicity of asbestos, which is thought to cause mesothelioma, has been clarified, its effect on antitumor immunity requires further investigation. We previously reported a decrease in the percentage of perforin + cells of stimulated CD8 + lymphocytes derived from patients with malignant mesothelioma. Therefore, we examined the effects of long-term exposure to asbestos on CD8 + T cell functions by comparing long-term cultures of the human CD8 + T cell line EBT-8 with and without exposure to chrysotile (CH) asbestos as an in vitro model. Exposure to CH asbestos at 5 μ g/ml or 30 μ g/ml did not result in a decrease in intracellular granzyme B in EBT-8 cells. In contrast, the percentage of perforin + cells decreased at both doses of CH exposure. CH exposure at 30 μ g/ml did not suppress degranulation following stimulation with antibodies to CD3. Secreted production of IFN- γ stimulated via CD3 decreased by CH exposure at 30 μ g/ml, although the percentage of IFN- γ + cells induced by PMA/ionomycin did not decrease. These results indicate that long-term exposure to asbestos can potentially suppress perforin levels and the production of IFN- γ in human CD8 + T cells." @default.
• W2896032634 created "2018-10-26" @default.
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• W2896032634 date "2018-10-23" @default.
• W2896032634 modified "2023-10-17" @default.
• W2896032634 title "Decrease in Intracellular Perforin Levels and IFN-γ Production in Human CD8+ T Cell Line following Long-Term Exposure to Asbestos Fibers" @default.
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• W2896032634 doi "https://doi.org/10.1155/2018/4391731" @default.
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