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- W2896033738 abstract "The pathology of Alzheimer's Disease (AD) results in behavioral problems which include memory deficits, psychiatric symptoms, and impaired social behavior. Previous research has concentrated on memory deficits, resulting in a lack of attention to the psychiatric symptoms and impaired social behavior components. The present study assessed social behavior in a transgenic mouse model of AD (3xTg) using the three-chamber social interaction task. In this task, sociability is measured by the subjects’ preference for investigating a conspecific over a novel object. Social recognition is measured by the subjects’ preference for a novel conspecific over a familiar conspecific. Further, we tested the utility of the three-chamber task as a test of social memory persistence by varying the delay (0, 20, 120, and 240 min) between initial exposure to the familiar conspecific and the recognition test. Using sniff time as our measurement of preference, we found that both WT and 3xTG mice had a preference for a conspecific over a novel object. In the social recognition test, WT mice preferred the novel conspecific, but 3xTg showed no preference indicating an impairment in social recognition. Neither genotype preferred the novel conspecific when the delay was increased to 20, 120, or 240 minutes showing that even in WT mice, social memory is disrupted by a short delay. Overall, these data support the use of the 3xTg mouse as a model for the impaired social behavior that occurs in AD." @default.
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- W2896033738 date "2018-07-01" @default.
- W2896033738 modified "2023-10-16" @default.
- W2896033738 title "P4‐226: SOCIAL BEHAVIOR OF THE TRIPLE‐TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE" @default.
- W2896033738 doi "https://doi.org/10.1016/j.jalz.2018.07.047" @default.
- W2896033738 hasPublicationYear "2018" @default.
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